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1,049,261 grants matching “t cell”
Advancing Transplantation Tolerance in Nonhuman Primates
$3,635,295Andrew B Adams · University Of Minnesota · U19 · FY2023 · AI
Advancing Transplantation Tolerance in Nonhuman Primates
$3,635,295Andrew B Adams · University Of Minnesota · U19 · FY2025 · AI
Advancing Transplantation Tolerance in Nonhuman Primates
$3,635,295Andrew B Adams · University Of Minnesota · U19 · FY2024 · AI
CHEMOPREVENTION OF SKIN CANCER PROGRAM PROJECT
$3,634,795University Of Arizona · P01 · FY2004 · CA
Border Biomedical Research Center
$3,634,786Robert Kirken · University Of Texas El Paso · U54 · FY2023 · MD
Structural Biology Center for HIV/HOST Interactions in Trafficking and Assembly
$3,634,352Wesley Ian Sundquist · University Of Utah · P50 · FY2010 · GM
CSHL CANCER CENTER SUPPORT GRANT
$3,633,951Cold Spring Harbor Laboratory · P30 · FY2002 · CA
Comprehensive characterization of the Drosophila transcriptome
$3,633,851Susan E Celniker · University Of Calif-Lawrenc Berkeley Lab · U01 · FY2007 · HG
Systems Biology of Cell Decision Processes
$3,631,635Massachusetts Institute Of Technology · P50 · FY2003 · GM
Statistics and Data Management Center-CSCC
$3,631,329Rho Federal Systems Division, Inc. · U54 · FY2004 · HL
A Data Resource for Analyzing Blood and Marrow Transplants
$3,630,895Mary M Horowitz · Medical College Of Wisconsin · U24 · FY2019 · CA
ROBOTIC EXPLORATION AND LIFE SEARCH ON OCEAN WORLDS REQUIRES THE ABILITY TO ACCESS HABITABLE OCEAN ENVIRONMENTS CONCEALED BENEATH THICK ICE CRUSTS. ADDITIONALLY AN INSTRUMENT SUITE IS REQUIRED TO PERFORM THE COMPLICATED TASK OF AUTONOMOUS LIFE DETECTION. WE PROPOSE TO ADDRESS THESE TECHNOLOGICAL AND OPERATIONAL REQUIREMENTS FOR OCEAN WORLD ACCESS WITH THOR A ROBUST CRYOBOT CAPABLE OF RAPID (10 M/HR) DEEP (500+ M) SUBGLACIAL ACCESS THAT CARRIES AN ONBOARD SCIENCE PAYLOAD OPTIMIZED FOR ENVIRONMENTAL CHARACTERIZATION AND LIFE DETECTION. THOR WILL BE DEPLOYED AT THE EASTERN SKAFTAFELL SUBGLACIAL LAKE IN VATNAJOKULL ICELAND WHERE IT WILL PENETRATE THE THICK ICE COVER OF THE LAKE. SUCCESSFUL FIELDING OF THOR WILL MARK THE FIRST CRYOBOT DESCENT INTO A SUBGLACIAL LAKE THUS ENABLING UNIQUE INVESTIGATIONS OF BOTH THE LAKE'S GEOMICROBIOLOGY AND OF CONOPS STRATEGIES FOR A CRYOBOT'S ENTRY INTO AND DESCENT THROUGH A SUBGLACIAL BODY OF WATER. THE THOR TEAM LEVERAGES SUCCESSFUL WORK FROM THE VALKYRIE AND SPINDLE PROJECTS AND OFFERS FIDELITY TO PSTAR IN THE AREAS OF SCIENCE SCIENCE OPERATIONS AND TECHNOLOGY. A) SCIENCE: INVESTIGATIONS OF THE EASTERN SKAFTAFELL LAKE WILL CENTER AROUND DETECTING AND CHARACTERIZING MICROORGANISMS IN THE WATER COLUMN AND VOLCANIC VENTS TO DECIPHER THE CONTRIBUTION OF CHEMICAL ENERGY LIBERATED FROM GEOTHERMAL VS. GLACIOLOGICAL PROCESSES. TO AID THESE INVESTIGATIONS THOR WILL CARRY A SUITE OF INSTRUMENTS CHOSEN TO CHARACTERIZE THE ENVIRONMENT OF THE ICE AND SUBGLACIAL LAKE WITH A SPECIFIC FOCUS ON LIFE-DETECTION STRATEGIES. ONBOARD INSTRUMENTS WILL INCLUDE A FLUORESCENCE SPECTROMETER A HOLOGRAPHIC MICROSCOPE CAPABLE OF IMAGING PROKARYOTIC CELLS AN INORGANIC CHEMISTRY MEASUREMENT SUITE A TRANSMISSOMETER / BACKSCATTERING SENSOR AND A WATER SAMPLER. A NANOPORE DNA SEQUENCER WILL BE USED ON-SITE TO ANALYZE WATER SAMPLES ACQUIRED BY THOR. COMPARATIVE ANALYSIS WILL UTILIZE WATER COLUMN AND VENT MATERIAL SAMPLES WHICH WILL BE RETURNED TO THE SURFACE AND ANALYZED. B) SCIENCE OPERATIONS: AT SKAFTAFELL THE THOR CRYOBOT WILL PENETRATE A 300 M THICK GLACIER AND ENTER THE SUBGLACIAL LAKE IN THE VOLCANO'S CRATER. UPON REACHING THE ICE-WATER INTERFACE THE CRYOBOT WILL TRANSITION INTO AN INSTRUMENT SONDE AND SPOOL ITSELF TO THE LAKE FLOOR WHILE SAMPLING AND ANALYZING THE WATER COLUMN. THIS PENETRATOR-TO-SONDE STRATEGY IS A NEW STEP-WISE APPROACH TO THE INITIAL EXPLORATION OF AN ALIEN OCEAN. AS THE VEHICLE DESCENDS INPUT FROM THE SENSOR SUITE WILL GOVERN DECISION-TO-COLLECT BEHAVIORS TO TRIGGER PROCESSES SUCH AS WATER SAMPLING. THE SYSTEM WILL BE RETRIEVED AFTER EACH MISSION AND WE ANTICIPATE COMPLETING SEVERAL DESCENTS IN EACH OF TWO FIELD SEASONS. EXPLORING METHODS WHICH COULD BE USED TO DETECT EXTANT LIFE ON OCEAN WORLDS IS OF HIGH IMPORTANCE. TO THAT END WE WILL ASSESS HOW WELL AND IN WHAT WAYS THE SUITE OF INSTRUMENTS FUNCTION TOGETHER TO DETERMINE WHETHER LIFE IS PRESENT AND AT WHAT QUANTITIES. CONVENTIONAL LIMNOLOGICAL AND MICROBIOLOGICAL TECHNIQUES USING WATER SAMPLES ACQUIRED BY THOR WILL BE USED TO EVALUATE AUTONOMOUS SAMPLING DECISIONS. C) TECHNOLOGY: THE CRYOBOT DESIGN WILL USE A CLOSED-CYCLE HOT WATER DRILL APPROACH WHEREIN THE WATER IS HEATED IN A NOVEL WAY: HIGH VOLTAGE IS APPLIED ACROSS A FLOWING COLUMN OF WATER WHICH SERVES AS THE RESISTIVE ELEMENT IN AN ELECTRO-RESISTIVE HEATER. ENERGY TRANSFER FROM THE ELECTRICAL SOURCE TO THE WATER IS INSTANTANEOUS AND OCCURS AT 100% EFFICIENCY. DIRECT HIGH VOLTAGE HEATING COMBINED WITH NEW INSULATION TECHNOLOGY MAKES POSSIBLE A COMPACT CRYOBOT THAT IS CAPABLE OF RAPID DESCENT AND DEEP SUBGLACIAL ACCESS WITH A SMALL FIELDLOGISTICS FOOTPRINT. GIVEN ITS SIMPLICITY THE CRYOBOT WILL BE INEXPENSIVE EASILY DEPLOYABLE AND FIELD SERVICEABLE. THE THOR PLATFORM WILL ENABLE UNPRECEDENTED ACCESS TO SUBGLACIAL ENVIRONMENTS MAKING IT AN IDEAL PAYLOAD DELIVERY SYSTEM FOR OCEAN WORLDS TECHNOLOGY DEVELOPMENT AND ANALOG RESEARCH IN THIS PSTAR PROJECT AND BEYOND.
$3,630,850Stone Aerospace, Inc. · · FY2020 · National Aeronautics and Space Administration
TREATMENT OF PERIPHERAL VASCULAR DISEASE BY ADIPOSE-DERIVED STROMAL CELL INJECTION
$3,630,690Tissue Genesis, Inc · · FY2009 · Department of the Army
Neurotoxicity in the adult rat following chronic exposure to methamphetamine
$3,629,955Jean Lud Cadet · National Institute On Drug Abuse · ZIA · FY2024 · DA
PROGRAM PROJECT GROWTH CONTROL OF MULTIPLE MYELOMA
$3,629,780University Of Arkansas Med Scis Ltl Rock · P01 · FY2002 · CA
Sensorimotor processing, decision making, and internal states: towards a realistic multiscale circuit model of the larval zebrafish brain
$3,629,683Florian Engert · Harvard University · U19 · FY2021 · NS
The Psychiatric Cell Map Initiative: Connecting Genomics, Subcellular Networks, and Higher Order Phenotypes
$3,628,784Nevan J Krogan · University Of California, San Francisco · U01 · FY2020 · MH
NEWBORN SCREEING TRANSLATIONAL RESEARCH NETWORK COORD CTR
$3,628,283Melissa T Forburger · American College Of Medical Genetics · N01 · FY2010 · HD
Nebraska Research Network in Functional Genomics
$3,628,200Paul L Sorgen · University Of Nebraska Medical Center · P20 · FY2021 · GM
State-dependent Decision-making in Brainwide Neural Circuits
$3,627,888Liam M Paninski · Columbia Univ New York Morningside · U19 · FY2023 · NS
Comparative Functional Genomics INBRE in Maine
$3,627,800James A Coffman · Mount Desert Island Biological Lab · P20 · FY2017 · GM
Growth Control in Multiple Myeloma
$3,627,570Bart Barlogie · Univ Of Arkansas For Med Scis · P01 · FY2012 · CA
Nebraska Research Network in Functional Genomics
$3,627,570Paul L Sorgen · University Of Nebraska Medical Center · P20 · FY2024 · GM
Nebraska Research Network in Functional Genomics
$3,627,570Paul L Sorgen · University Of Nebraska Medical Center · P20 · FY2022 · GM
Nebraska Research Network in Functional Genomics
$3,627,570Paul L Sorgen · University Of Nebraska Medical Center · P20 · FY2023 · GM