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15,273 grants matching “antimicrobial resistance”
IRGM proteins as regulators of inflammation
$469,814Gregory A Taylor · Duke University · R01 · FY2020 · AI
Ceftriaxone Immunomodulation and Antimicrobial Effects After Cardiac Arrest
$469,755David Gagnon · Mainehealth · P20 · FY2022 · GM
Digital High Resolution Melt and Machine Learning for Rapid and Specific Diagnosis in Neonatal Sepsis
$469,594Stephanie Irene Fraley · University Of California, San Diego · R01 · FY2021 · AI
DESPITE ON-GOING REGULATORY AND INDUSTRY EFFORTS, MICROBIAL FOOD SAFETY ISSUES REMAIN THE PRIMARY FOOD SAFETY CONCERN IN THE UNITED STATES, WITH CONTAMINATION FROM PROCESSING PLANT ENVIRONMENTS BEING A KEY ISSUE FOR MOST SECTORS OF THE READY-TO-EAT (RTE) INDUSTRY. IMPORTANTLY, PERSISTENCE OF PATHOGENIC MICROORGANISMS IN NON-FOOD CONTACT ZONE 2/3 GROWTH NICHES LIKE DRAINS REPRESENTS AN UNDER-INVESTIGATED, YET INCREASINGLY IMPORTANT, AREA OF RESEARCH NEED IN IMPROVING FOOD SAFETY. ANTIMICROBIAL COATINGS CAN REDUCE MICROBIAL SURVIVAL BUT SUFFER POOR PERFORMANCE UNDER CONDITIONS OF HIGH ORGANIC LOAD AND TYPICALLY RELY ON LEACHING OF ANTIMICROBIAL AGENTS. MANY NON-FOULING COATINGS HAVE DEMONSTRATED ABILITY TO RESIST PROTEIN CONDITIONING BUT ARE PRONE TO DEGRADATION UNDER CONDITIONS TYPICAL IN FOOD AND BEVERAGE PROCESSING. WE PROPOSE TO REDUCE ADHESION, SURVIVAL, AND CROSS-CONTAMINATION OF SALMONELLA AND L. MONOCYTOGENES IN DRAINS BY THE DEVELOPMENT AND APPLICATION OF A ROBUST, POLYMERIC COATING WITH BOTH ANTIMICROBIAL AND NON-FOULING PROPERTIES. WE WILL LEVERAGE AN EXTERNAL ADVISORY GROUP TO GUIDE MATERIALS DESIGN AND APPLICATIONS STUDIES TO ENSURE INDUSTRY RELEVANCE. THE INVESTIGATORS COMBINE INDUSTRY EXPERIENCE WITH EXPERTISE IN FOOD SCIENCE, POLYMER SYNTHESIS, FOOD PROCESSING, AND FOOD MICROBIOLOGY. THE LONG TERM IMPACT OF THIS PROJECT IS IN SUPPORT OF USDA NIFA GOALS TO DEVELOP STRATEGIES TO REDUCE FOODBORNE CONTAMINANTS IN FOODS OR THE ENVIRONMENT AT ANY POINT ALONG THE FOOD SUPPLY CHAIN, SPECIFICALLY IMPROVING CONTROL STRATEGIES FOR FOODBORNE CONTAMINANTS AND IMPROVING MANUFACTURING AND PROCESSING TECHNOLOGIES THAT ENHANCE FOOD SAFETY. THE PROPOSED COATINGS WILL ADDRESS UNMET RESEARCH NEEDS IN CONTROLLING PATHOGEN PERSISTENCE IN ZONE 2/3 GROWTH NICHES, AND INCREASINGLY IMPORTANT AREA OF RESEARCH FOR IMPROVING THE SAFETY OF OUR FOOD SUPPLY.
$469,587Cornell University · · FY2018 · National Institute of Food and Agriculture
Subproject 4 Antimicrobials and Efflux Pumps in Staphylococcus aureus Infection
$469,523David C Hooper · Massachusetts Eye And Ear Infirmary · P01 · FY2017 · AI
Genetic Analyses of bacteremia non-typhoidal Salmonella
$469,500Micah Worley · University Of Louisville · R15 · FY2023 · AI
Mechanisms and use of penicillin-binding protein inhibition to optimize cationic peptide anti-MRSA treatment
$469,355Warren E Rose · University Of Wisconsin-Madison · R01 · FY2018 · AI
Innate immune responses to microbial flora
$469,260Eric G Pamer · Sloan-Kettering Inst Can Research · R01 · FY2010 · AI
THE OVERARCHING LONG-TERM GOAL OF THIS PROJECT IS TO IMPROVE FOOD-BORNE DISEASE (FBD) SURVEILLANCE AND DETECTION TECHNOLOGY THAT WILL ALLOW FOR THE EVENTUAL REDUCTION AND PREVENTION OF MICROBIAL CONTAMINATION ACROSS THE COMPLETE NETWORK OF FOOD PRODUCTION, REDUCTION OF THE RECALL RATE DUE TO FOOD CONTAMINATION, AND THE ULTIMATE REDUCTION OF THE FBD BURDEN (INCLUDING THE ACCOMPANYING ANTIMICROBIAL RESISTANCE IMPACT). WE PROPOSE TO ADVANCE THE CAPACITY FOR NEXT GENERATION SURVEILLANCE OF FBD PATHOGENS ACROSS THE FOOD PRODUCTION NETWORK THROUGH THE DEVELOPMENT OF FOOD-PATH, AN ADVANCED, BUT ACCESSIBLE, AMPLICON SEQUENCING-BASED FBD SURVEILLANCE TOOL. TO ACCOMPLISH THIS WE WILL ACHIEVE THE FOLLOWING OBJECTIVES: 1) DEVELOP A HIGH-THROUGHPUT AMPLICON SEQUENCING ASSAY SYSTEM (INCLUDING AUTOMATED DATA ANALYSIS) TO DETECT FBD ORGANISMS THAT ARE RELEVANT TO BOTH FOOD SAFETY AND PUBLIC HEALTH; 2) EVALUATE THE FOOD-PATH TOOL'S ABILITY TO DETECT AND CHARACTERIZE CRITICAL FBD PATHOGENS IN UPSTREAM AND DOWNSTREAM FOOD PROCESSING SAMPLES (I.E., COMPLEX MIXED GENOME SAMPLES); AND 3) EVALUATE THE ABILITY OF FOOD-PATH TO DISCERN STRAIN TYPES, SEROTYPES AND OTHER GENOTYPES WITH COMPARATIVE WHOLE GENOME SEQUENCING.
$469,220Translational Genomics Research Institute · · FY2018 · National Institute of Food and Agriculture
Genomics approaches to elucidating pathways to antibiotic resistance in Neisseria gonorrhoeae
$469,104Yonatan H Grad · Harvard University D/B/A Harvard School Of Public Health · R01 · FY2024 · AI
Experiment based genome mining of ribosomal natural products
$469,024Pieter C Dorrestein · University Of California, San Diego · R01 · FY2014 · GM
Experiment based genome mining of ribosomal natural products
$469,024Pieter C Dorrestein · University Of California, San Diego · R01 · FY2015 · GM
iCAP An Innovative Device to Rapidly Resolve Microbial Keratitis
$468,754Anjal C Sharma · Lynntech, Inc. · R44 · FY2021 · EY
Novel Electrochemical Bandage for Treatment of Wound Infections
$468,744Robin Patel · Mayo Clinic Rochester · R01 · FY2022 · AI
Targeting a novel regulatory RNA with novel antibiotics
$468,723Jennifer V Hines · Ohio University Athens · R01 · FY2010 · GM
Experiment based genome mining of ribosomal natural products
$468,654Pieter C Dorrestein · University Of California, San Diego · R01 · FY2012 · GM
Improved Therapeutics and Diagnostics for Pneumocystis Pneumonia
$468,554Jay K Kolls · Tulane University Of Louisiana · R01 · FY2025 · AI
Subproject 1 Compounds and Strategies for Treating MRSA and VRE
$468,315Suzanne L. Walker · Massachusetts Eye And Ear Infirmary · P01 · FY2019 · AI
De-Implementation of Unnecessary Surgical Antibiotic Prophylaxis in Children
$468,237Virginia R McKay · Washington University · R01 · FY2023 · HS
Molecular targets in peptidoglycan synthesis
$468,164Christopher Davies · Medical University Of South Carolina · R01 · FY2016 · GM
Mathematical Modeling Core
$467,912Stephan Schmidt · University Of Florida · P01 · FY2016 · AI
Bacterial cell wall synthesis, shape and septation
$467,882Kevin D Young · Univ Of Arkansas For Med Scis · R01 · FY2015 · GM
Bacterial cell wall synthesis, shape and septation
$467,882Kevin D Young · Univ Of Arkansas For Med Scis · R01 · FY2016 · GM
Bacterial cell wall synthesis, shape and septation
$467,882Kevin D Young · Univ Of Arkansas For Med Scis · R01 · FY2014 · GM
Upc2A: A Central Regulator and "Achilles' Heel" of Fluconazole Resistance in Candida glabrata
$467,798P David Rogers · University Of Tennessee Health Sci Ctr · R01 · FY2020 · AI