Sort
15,273 grants matching “antimicrobial resistance”
Plasma Protein Biomarker-Based Diagnostics Of Outcome In Sepsis and CAP
$491,218Stephen Francis Kingsmore · National Center For Genome Resources · U01 · FY2008 · AI
Listeria monocytogenes physiology and host pathogen interactions
$491,061Joshua Woodward · University Of Washington · R01 · FY2021 · AI
Listeria monocytogenes physiology and host pathogen interactions
$491,061Joshua Woodward · University Of Washington · R01 · FY2022 · AI
Listeria monocytogenes physiology and host pathogen interactions
$491,061Joshua Woodward · University Of Washington · R01 · FY2024 · AI
Listeria monocytogenes physiology and host pathogen interactions
$491,061Joshua Woodward · University Of Washington · R01 · FY2023 · AI
Listeria monocytogenes physiology and host pathogen interactions
$491,061Joshua Woodward · University Of Washington · R01 · FY2020 · AI
Molecular mechanisms of uropathogenesis
$491,010Harry L. Mobley · University Of Michigan At Ann Arbor · R01 · FY2020 · AI
Enhancing Patient Safety by Preventing Urinary Tract Infection in Post-Acute Care
$490,803Lona Mody · University Of Michigan At Ann Arbor · R01 · FY2020 · HS
A Nanofibrous Bioactive Hemodialysis Access Graft
$490,704Saif G Pathan · Biosurfaces · R44 · FY2013 · DK
Dual-Stimuli Responsive Antibiotic-Loaded Nanoparticles: A New Strategy to Overcome Antimicrobial Resistance
$490,606Shaoqin - Gong · University Of Wisconsin-Madison · R01 · FY2023 · AI
A Novel Antimicrobial Mimetic for Oral Candidiasis
$490,539Richard W Scott · Polymedix, Inc, · R44 · FY2011 · DE
Host-microbiome interactions shape the metabolic effects of ketogenic diets
$490,405Peter James Turnbaugh · University Of California, San Francisco · R01 · FY2024 · DK
Antibiotic Potentiation by Targeting of a Signal Transduction System
$490,150Robert S. Daum · University Of Maryland Baltimore · R33 · FY2018 · AI
Insulin Signaling Activates Urothelial Defenses to Reduce Urinary Tract Infection Susceptibility
$490,096John David Spencer · Research Inst Nationwide Children'S Hosp · R01 · FY2024 · DK
Malaria Topoisomerase inhibitors
$490,036Pradipsinh K. Rathod · University Of Washington · R01 · FY2019 · AI
Malaria Topoisomerase inhibitors
$490,036Pradipsinh K. Rathod · University Of Washington · R01 · FY2020 · AI
Nitric Oxide and Severe Malaria
$490,014Duke University · R21 · FY2002 · AI
THIS PROJECTS WORKS ON EXPLORING ALTERNATIVES FOR ANTIBIOTICS IN VETERINARY MEDICINE. ANTIBIOTICS ARE WIDELY USED TO TREAT BACTERIAL DISEASES IN BOTH ANIMALS AND HUMANS. HOWEVER, OVERUSE CAN LEAD TO ANTIMICROBIAL RESISTANCE, WHICH IS RECOGNIZED AS A GLOBAL HEALTH CONCERN.OUR LABORATORY STUDIES THE THERAPEUTIC POTENTIAL OF EQUINE MESENCHYMAL STEM CELLS (MSC), A TYPE OF ADULT STEM CELLS ISOLATED FROM THE BLOOD OF HORSES, IN EQUINE WOUND MANAGEMENT. A COMMON COMPLICATION OF EQUINE WOUNDS IS BACTERIAL INFECTIONS AND WE RECENTLY FOUND THAT EQUINE MSC SECRETE FACTORS THAT CAN INHIBIT THE GROWTH OF BACTERIA COMMONLY FOUND IN SKIN WOUNDS OF HORSES.THIS PROJECT WILL WORK ON FURTHER STUDYING THE POTENTIAL OF EQUINE MSC TO FIGHT BACTERIAL INFECTIONS. THE SPECIFIC SCIENCE OBJECTIVES ARE TO DETERMINE HOW EQUINE MSC-DERIVED SECRETED FACTORS INHIBIT THE GROWTH OF BACTERIA AND BOOST HOST-INTRINSIC ANTIMICROBIAL DEFENSE SYSTEMS IN THE LABORATORY (IN VITRO) AS WELL AS IN HORSES WITH INFECTED WOUNDS (INVIVO).ONCE WE UNDERSTAND HOW EQUINE MSC EXERT THEIR ANTIMICROBIAL EFFECTS, WE CAN DEVELOP EVIDENCE-BASED STRATEGIES TO (I) REDUCE THE NEGATIVE IMPACTS OF WOUND INFECTIONS IN HORSES AND (II) DECREASE THE USE OF ANTIBIOTICS BY USING MSC-DERIVED SECRETED FACTORS AS AN ALTERNATIVE THERAPY, NOT ONLY IN EQUINE MEDICINE, BUT VETERINARY MEDICINE IN GENERAL.
$489,908Cornell University · · FY2018 · National Institute of Food and Agriculture
High Efficiency Inhalation Delivery of Tobramycin for Children with Cystic Fibrosis
$489,791P. Worth Longest · Virginia Commonwealth University · R01 · FY2017 · HD
Multi-Drug Resistant Urinary Tract Infections in Ambulatory Settings
$489,720Ebbing Lautenbach · University Of Pennsylvania · R18 · FY2010 · HS
Bacterial Reprogramming that Contributes to Antibiotic Persistence toward Topoisomerase Inhibitors
$489,677Wendy W.k. Mok · University Of Connecticut Sch Of Med/Dnt · R01 · FY2025 · AI
MYCOBACTERIAL RESISTANCE TO REACTIVE NITROGEN/OXYGEN
$489,618Weill Medical College Of Cornell Univ · R01 · FY2002 · HL
Mechanisms of Salmonella-mediated disruption of colonization resistance in the inflamed gut
$489,526Mariana Xavier Byndloss · Vanderbilt University Medical Center · R01 · FY2024 · AI
Mechanisms of Salmonella-mediated disruption of colonization resistance in the inflamed gut
$489,526Mariana Xavier Byndloss · Vanderbilt University Medical Center · R01 · FY2023 · AI
Mechanisms of Salmonella-mediated disruption of colonization resistance in the inflamed gut
$489,526Mariana Xavier Byndloss · Vanderbilt University Medical Center · R01 · FY2025 · AI