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15,273 grants matching “antimicrobial resistance”
Translational Multimodal Strategy for Peri-Implant Disease Prevention
$495,839Geelsu Hwang · University Of Pennsylvania · R01 · FY2024 · DE
Hospital-Acquired Mupirocin-Resistant MRSA in Post-Partum Women and Newborns
$495,830Sharon Beth Brodie Wright · Beth Israel Deaconess Medical Center · R18 · FY2014 · HS
Crystal Structure of the Ribosome
$495,707Harry F Noller · University Of California Santa Cruz · R01 · FY2011 · GM
Efficacy of oral vancomycin prophylaxis for prevention of recurrent C. difficile infection
$495,651Nasia Safdar · University Of Wisconsin-Madison · R01 · FY2017 · HS
Control of Endoplasmic Reticulum Tubule Formation by Legionella pneumophila
$495,564Ralph R Isberg · Tufts University Boston · R01 · FY2016 · AI
Control of Endoplasmic Reticulum Tubule Formation by Legionella pneumophila
$495,564Ralph R Isberg · Tufts University Boston · R01 · FY2015 · AI
Control of Endoplasmic Reticulum Tubule Formation by Legionella pneumophila
$495,564Ralph R Isberg · Tufts University Boston · R01 · FY2014 · AI
Targeting hybrid histidine kinase for broad spectrum antifungal therapy
$495,552Bruce Steven Klein · University Of Wisconsin-Madison · RC1 · FY2010 · AI
NETWORK ON ANTIMICROBIAL RESISTANCE IN STAPHTLOCOCCUS A
$495,467Focus/Mrl, Inc.-Mrl Pharmaceutical Srvs · N01 · FY2000 · AI
Divergence of Phagocytic and Antimicrobial Programs in Leprosy
$495,465Robert L Modlin · University Of California Los Angeles · R01 · FY2010 · AI
Tear Protein Microbial Regulation
$495,316Gordon William Laurie · University Of Virginia · R01 · FY2021 · EY
Chemical Address Tags: A Cheminformatics & Image Data Management and Analysis Pla
$495,014Gus R Rosania · University Of Michigan At Ann Arbor · R01 · FY2014 · GM
Host and bacterial enzyme-mediated approaches to produce durable direct and indirect restorations
$494,991Carmem S. Pfeifer · Oregon Health & Science University · R01 · FY2019 · DE
Viral and Bacterial DNA Ligases
$494,856Stewart H Shuman · Sloan-Kettering Inst Can Research · R01 · FY2009 · GM
ID. of Pathways that can be Targeted for the Develop. of Novel Therapies for MRSA
$494,763Eleftherios Mylonakis · Massachusetts Eye And Ear Infirmary · P01 · FY2011 · AI
Peptide-mediated immunotherapy of KSHV-associated malignancy.
$494,752Jae U Jung · University Of Southern California · RC1 · FY2009 · CA
Viral and Bacterial DNA Ligases
$494,671Stewart H Shuman · Sloan-Kettering Inst Can Research · R01 · FY2011 · GM
Coordinate Regulation of Salmonella Virulence and Antimicrobial Resistance by MarR Transcription Factors
$494,667Ferric C Fang · University Of Washington · R01 · FY2024 · AI
Coordinate Regulation of Salmonella Virulence and Antimicrobial Resistance by MarR Transcription Factors
$494,667Ferric C Fang · University Of Washington · R01 · FY2022 · AI
Coordinate Regulation of Salmonella Virulence and Antimicrobial Resistance by MarR Transcription Factors
$494,667Ferric C Fang · University Of Washington · R01 · FY2023 · AI
Functional genomics analysis of colonization and persistence of Enterococcus faecalis in the gastrointestinal tract.
$494,652Gary M Dunny · University Of Minnesota · R01 · FY2017 · AI
BOVINE RESPIRATORY DISEASE (BRD) IS THE LEADING CAUSE OF MORBIDITY AND MORTALITY IN BEEF CATTLE, AND MASS ANTIMICROBIAL ADMINISTRATION (METAPHYLAXIS) IS THE MOST EFFECTIVE PREVENTION. METAPHYLAXIS CAN ALSO BE LIFE-SAVING IN OTHER LIVESTOCK AND HUMANS, BUT THE PRACTICE MAY BE COMPROMISED BY SPREAD OF MULTIDRUG RESISTANT (MDR) PATHOGENS. MDR ISOLATES OF THE BRD PATHOGEN MANNHEIMIA HAEMOLYTICA CAN BE FOUND IN 90% OF SOME CATTLE 14 DAYS AFTER METAPHYLAXIS. THE MECHANISMS LEADING TO MDR AFTER METAPHYLAXIS ARE UNKNOWN, BUT RAPID TRANSFER OF MOBILE GENETIC ELEMENTS (MGE) ENCODING ANTIMICROBIAL RESISTANCE (AMR) IS LIKELY. USING A RANDOMIZED FIELD TRIAL ASSESSING TREATED AND UNTREATED CONVENTIONALLY MANAGED CATTLE, WE WILL 1) COMPARE PREVALENCE OF NASOPHARYNGEAL MDR M. HAEMOLYTICA ISOLATES, AMR GENES, AND MGE, USING CULTURE, SUSCEPTIBILITY TESTING, AND WHOLE GENOME SEQUENCING; 2) COMPARE NASOPHARYNGEAL METAGENOMES, USING 16S AMPLICON SEQUENCING; 3) COMPARE THE NASOPHARYNGEAL RESISTOME, USING TARGET-ENRICHED SEQUENCING OF AMR AND MGE GENE SEQUENCES; AND 4) USE TARGET-ENRICHED SEQUENCING TO COMPARE ABSOLUTE ABUNDANCE OF M. HAEMOLYTICA AND SEQUENCES SPECIFIC TO OTHER BRD PATHOGENS. THIS APPROACH WILL PROVIDE UNPRECEDENTED RESOLUTION OF THE ECOLOGY OF RESPIRATORY AMR IN CATTLE RECEIVING METAPHYLAXIS, REVEALING TARGETS FOR MITIGATING AMR. THIS RESEARCH SUPPORTS SUSTAINABILITY OF U.S. AGRICULTURE WITH EVIDENCE-BASED STRATEGIES TO ENSURE LIVESTOCK HEALTH AND LIMIT AMR, BY IMPROVING UNDERSTANDING OF THE EMERGENCE AND TRANSMISSION OF MGE ENCODING AMR TO MEDICALLY IMPORTANT AM, AND DEVELOPING TOOLS TO TRACK AMR GENES IN ANIMAL ENVIRONMENTS.
$494,596Mississippi State University · · FY2019 · National Institute of Food and Agriculture
Antibiotic Drug Discovery
$494,456Toni B. Kline · University Of Washington · U54 · FY2010 · AI
Role of the environmental sensor, AhR on colitis
$494,400Prakash S. Nagarkatti · University Of South Carolina At Columbia · R01 · FY2023 · AI
Tim3 and Mycobacterium tuberculosis
$494,393Samuel M Behar · Univ Of Massachusetts Med Sch Worcester · R01 · FY2013 · AI