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15,273 grants matching “antimicrobial resistance”
Hospital-Acquired Mupirocin-Resistant MRSA in Post-Partum Women and Newborns
$497,372Sharon Beth Brodie Wright · Beth Israel Deaconess Medical Center · R18 · FY2012 · HS
A Nanofibrous Bioactive Hemodialysis Access Graft
$497,370Saif G Pathan · Biosurfaces · R44 · FY2012 · DK
Biomarkers for Urinary Tract Infection and Pyelonephritis
$497,274Nader Shaikh · University Of Pittsburgh At Pittsburgh · R01 · FY2024 · DK
Ceftriaxone Immunomodulation and Antimicrobial Effects After Cardiac Arrest
$497,251David Gagnon · Mainehealth · P20 · FY2023 · GM
Antimicrobial Use in Dialysis Units
$497,234Erika M D'agata · Beth Israel Deaconess Medical Center · R18 · FY2013 · HS
Role of the environmental sensor, AhR on colitis
$497,231Prakash S. Nagarkatti · University Of South Carolina At Columbia · R01 · FY2022 · AI
THE OVERALL PROJECT GOAL IS TO PROVIDE THE AGRICULTURAL COMMUNITY WITH A NOVEL, VALIDATED AND HIGHLY DISCRIMINATIVE METHOD FOR TRACKING AND SOURCE ATTRIBUTION OF ANTIMICROBIAL RESISTANCE IN ENVIRONMENTAL SYSTEMS, LEVERAGING NUCLEOTIDE-LEVEL VARIATION WITHIN RESISTOME DATA.THE FOLLOWING OBJECTIVES SUPPORT THIS GOAL: 1) DEVELOPMENT OF COMPUTATIONAL ALGORITHMS AND STATISTICAL METHODS FOR GENERATING NUCLEOTIDE-LEVEL RESISTOME FINGERPRINTS FROM METAGENOMIC DATA; 2) EVALUATION OF THE APPLIED BENEFIT OF RESISTOME FINGERPRINTS UTILIZING BOTH SIMULATED AND PUBLIC METAGENOMIC DATA FROM DISTANTLY AND CLOSELY RELATED SAMPLES; 3) VALIDATION OF THE HIGH DISCRIMINATIVE CAPACITY OF RESISTOME FINGERPRINTS USING EXPERIMENTALLY GENERATED DATA; AND 4) SUSTAINMENT OF THE METHOD VIA AN INTEGRATED OUTREACH CAMPAIGN.TO ACCOMPLISH THESE OBJECTIVES, WE WILL FIRST IDENTIFY AND MODIFY COMPUTATIONAL ALGORITHMS FOR NUCLEOTIDE-LEVEL VARIANT DETECTION IN METAGENOMIC DATA. NEXT, RESISTOME FINGERPRINTS WILL BE GENERATED USING ADVANCED STATISTICAL METHODS COMBINING NUCLEOTIDE VARIANTS, SNP CALLING AND DISTANCE-BASED COMPARISON METRICS. METHODS WILL BE APPLIED TO SIMULATED AND PUBLIC METAGENOMIC DATA TO EVALUATE PERFORMANCE ON REAL DATA. TOP-PERFORMING METHODS WILL BE STRESS TESTED WITH AN EXPERIMENTALLY GENERATED BENCHMARKING DATASET DERIVED FROM CLOSELY RELATED SOIL SAMPLES ACROSS A FINE GRADIENT OF RESISTOME DIFFERENCE; THIS ANALYSIS WILL ALSO ALLOW ESTIMATION OF THE DISCRIMINATIVE LIMIT OF RESISTOME FINGERPRINTS. FINALLY, THE FINGERPRINTING METHODOLOGY AND BENCHMARKING DATASET WILL BE PACKAGED INTO AN ACCESSIBLE PIPELINE FOR FUTURE AND SUSTAINED USE.THIS PROJECT HAS DIRECT RELEVANCE TO THE GOALS OF PROGRAM AREA PRIORITY UNDERSTANDING ANTIMICROBIAL RESISTANCE, AS IT WILL PROVIDE A NOVEL METHOD TO TRACK AND MONITOR THE FATE, TRANSPORT, OR ROLE...OF ANTIMICROBIAL RESISTANCE...IN THE ENVIRONMENT.
$497,117Regents Of The University Of Minnesota · · FY2019 · National Institute of Food and Agriculture
Quantifying Microbial Keratitis to Predict Outcomes: An Imaging and Epidemiologic Approach
$496,961Maria Anneke Woodward · University Of Michigan At Ann Arbor · R01 · FY2023 · EY
Impact of MRSA Decolonization Therapy on MRSA Infection and Transmission
$496,813Arch G Mainous · Medical University Of South Carolina · R01 · FY2011 · HS
Modular synthesis of antibiotic and anticancer classes of natural products
$496,800Ian Bass Seiple · Scripps Research Institute, The · R35 · FY2025 · GM
Implementing a Discharge Stewardship Bundle to improve antibiotic use at transition from hospital to home
$496,794Jeffrey Stephen Gerber · Children'S Hosp Of Philadelphia · R01 · FY2020 · HS
Reducing Antimicrobial Overuse in HCAP Through Personalized Antimicrobial Recommendations
$496,790Michael B Rothberg · Cleveland Clinic Foundation · R01 · FY2016 · HS
ANti-infective Stewardship using the Wisca tool in the Electronic medical Record
$496,727Lance Robert Peterson · Endeavor Health Clinical Operations · R01 · FY2014 · HS
New Functional Groups for Tailoring Polymer Properties
$496,696Brett Vanveller · Iowa State University · · FY2024 · MPS
Reducing Antimicrobial Overuse in HCAP Through Personalized Antimicrobial Recommendations
$496,661Michael B Rothberg · Cleveland Clinic Foundation · R01 · FY2018 · HS
Chemical probes for imaging and treatment of otitis media
$496,496Matthew S Bogyo · Stanford University · R01 · FY2025 · EB
Monochromatic 222 nm UV light: Development of a safe, cost-effective technology for the efficient reduction of bacterial and viral infection and transmission
$496,362Sung-Jin Park · Eden Park Illumination, Inc. · R42 · FY2020 · AI
Xylitol syrup for the prevention of acute otitis media in otitis-prone children
$496,295Louis Vernacchio · Boston Children'S Hospital · RC1 · FY2010 · DC
Enhancing the Capacity and Capability of Human Food and Environmental Testing Laboratory at the Texas Department of State Health Services: Overall
$496,257Susan Tanksley · Texas State Dept Of Health Services · U19 · FY2023 · FD
The pel exopolysaccharide gene cluster of Pseudomonas aeruginosa
$496,108Matthew R. Parsek · University Of Washington · R01 · FY2011 · AI
Improving Equitable Access to Penicillin Allergy De-Labeling
$496,080Kimberly Gold Blumenthal · Tufts Medical Center · R01 · FY2024 · HS
Dendritic cell KLF2/Notch Axis and Th2 Responses to Eukaryotic Pathogens
$496,000George S. Deepe · University Of Cincinnati · R01 · FY2017 · AI
Discovery of Gram-negative permeable chemical probes for tRNA methylation
$495,998Ya-Ming Hou · Thomas Jefferson University · R01 · FY2019 · AI
Enhancing Patient Safety by Preventing Urinary Tract Infection in Post-Acute Care
$495,994Lona Mody · University Of Michigan At Ann Arbor · R01 · FY2019 · HS
Pathobiology of heme inducible transporters in Gram positive pathogens
$495,963Eric P Skaar · Vanderbilt University Medical Center · R01 · FY2025 · AI