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46,585 grants matching “heart failure”
Blood DNA Methylation Biomarkers of Post AcuteSequelae of SARS CoV 2 Infection (PASC)
$812,430Adolfo Ariel Jaitovich · Albany Medical College · R01 · FY2023 · AI
Determining the Mechanisms of Radiation Biomodulation of the Ventricular Tachycardia Arrhythmogenic Substate
$812,403Cory Michael Tschabrunn · University Of Pennsylvania · R56 · FY2024 · HL
Clinical Trial to Slow the Progression of ADPKD
$812,219Robert W Schrier · University Of Colorado Denver · U01 · FY2009 · DK
Improving Care Transitions and Self-care among Informal Caregivers of Hospitalized Older Adults through Digital Tools
$812,042Karen B Hirschman · University Of Pennsylvania · R01 · FY2023 · AG
Mathematical Model-Based Optimization of CRT Response in Ischemia
$811,994Ghassan S Kassab · California Medical Innovations Institute · R01 · FY2023 · HL
Epigenomic mechanisms of cardiac fibrosis and heart failure
$811,885Michael Alexanian · J. David Gladstone Institutes · R01 · FY2025 · HL
Identification of common genetic variants for atrial fibrillation and PR interval
$811,807Emelia J. Benjamin · Boston University Medical Campus · R01 · FY2010 · HL
Risk stratification in pulmonary arterial hypertension: Intersection of OMICs and longitudinal phenotypes through the PAH Biobank
$811,691William C Nichols · Cincinnati Childrens Hosp Med Ctr · R01 · FY2022 · HL
Claude D. Pepper Older Americans Independence Center (OAIC)
$811,688Marco Pahor · University Of Florida · P30 · FY2011 · AG
HLD-mediated cholesterol efflux and plaque inflammation in MESA
$811,635Steven J Shea · Columbia University Health Sciences · R01 · FY2017 · HL
Renal Denervation in Heart Failure with Preserved Ejection Fraction
$811,603Traci Taylor Goodchild · Cedars-Sinai Medical Center · R01 · FY2023 · HL
Quantitative Proteomics to Develop Robust Senescence-Related Biomarkers for Aging
$811,526Birgit Schilling · Buck Institute For Research On Aging · U01 · FY2020 · AG
Proteomic discovery in an inception cohort of acute myocardial infarction survivors
$811,511James S Floyd · University Of Washington · R01 · FY2020 · HL
Feasibility of Unfrozen Sub-zero Storage of Mammalian Tissues with Insect Anti-Fr
$811,401Kelvin G.m. Brockbank · Cell And Tissue Systems, Inc. · R44 · FY2009 · DK
RAPID WARMING OF THE HIGH NORTHERN LATITUDES (HNL) HAS RESULTED IN SUBSTANTIAL CHANGES ACROSS NUMEROUS ASPECTS OF PHYSICAL AND BIOLOGICAL ENVIRONMENT OF ALASKA. UNLIKE MANY ENVIRONMENTAL CHANGES WHICH SHOW A LAGGED OR GRADUAL RESPONSE TO THE WARMING CONDITIONS WILDFIRE OCCURRENCE AND BEHAVIOR IS IMPACTED BY CHANGING METEOROLOGY ON VERY SHORT TIME SCALES. NUMEROUS STUDIES HAVE DEMONSTRATED A NOTABLE INCREASE IN FIRE OCCURRENCE ACROSS BOREAL FORESTS OF NORTH AMERICA OVER THE PAST 50 YEARS. MOREOVER FUTURE PROJECTIONS INDICATE THAT FIRE WILL CONTINUE TO OCCUR MORE FREQUENTLY AND RESULT IN MORE EXTENSIVE AND SEVERE BURNS. HOWEVER DESPITE THE EXTENSIVE FIRE OCCURRENCE AND IMPACTS ON THE LAND FIRE OCCURRENCE IN ALASKA IS RARELY VIEWED AS HAVING A SUBSTANTIAL IMPACT ON ITS POPULATION. CONSIDERING THE RELATIVELY LOW NUMBER OF PEOPLE LIVING IN ALASKA AND VAST EXPANSES OF WILDERNESS AREAS DIRECT IMPACT ON HUMAN LIFE AND PROPERTY HAS INDEED BEEN VERY LOW. HOWEVER FAIRLY LITTLE HAS BEEN DONE TO QUANTIFY THE IMPACT OF WILDFIRE EMISSIONS ON AIR QUALITY AND SUBSEQUENT HEALTH OF POPULATION IN ALASKA. .THE WORLD HEALTH ORGANIZATION RECENTLY ESTIMATED 3.7 MILLION DEATHS WORLDWIDE AND 94 000 IN HIGH INCOME AMERICAN COUNTRIES IN 2012 FROM EXPOSURE TO OUTDOOR AIR POLLUTION. THE MAJORITY OF THESE DEATHS ARE ATTRIBUTED TO CARDIOVASCULAR DISEASE AND AN ASSOCIATION BETWEEN CARDIOVASCULAR OUTCOMES IN GENERAL AND AMBIENT AIR POLLUTION IS WELL-ESTABLISHED. HOWEVER THE VAST MAJORITY OF THESE STUDIES HAVE FOCUSED ON TRAFFIC-RELATED AMBIENT AIR POLLUTION EXPOSURES AND VERY LITTLE RESEARCH HAS EXAMINED HOW EXPOSURES TO PARTICULATES FROM FOREST FIRES CONTRIBUTE TO THESE HEALTH OUTCOMES. WILDFIRES RELEASE LARGE AMOUNTS OF PARTICULATE MATTER (PM) WHICH IS TRANSPORTED FROM THE SOURCE AREAS ACROSS THE REGION FOLLOWING PREVAILING WIND PATTERNS WITH A CONSEQUENT SUBSTANTIAL IMPACT ON AIR QUALITY ACROSS THE STATE OF ALASKA AS A WHOLE. THE EXTENT INTENSITY AND LONGEVITY OF MANY FIRE EVENTS GENERALLY EXCEED THOSE IN THE CONTINENTAL US THUS ALLOWING FOR REPEATED PROLONGED PERIODS OF PM EXPOSURE IN DIFFERENT REGIONS OF THE STATE. PREVIOUS STUDIES HAVE SHOWN THAT PM FROM WILDFIRES IS MORE TOXIC TO THE HUMAN LUNG COMPARED TO THE SAME LEVELS OF PM POLLUTION FROM AMBIENT SOURCES. ADDITIONALLY STUDIES HAVE SHOWN AN INCREASE IN RESPIRATORY DISTRESS IN VULNERABLE GROUPS OF POPULATION DURING INTENSE BUT SHORT-LIVED WILDFIRE EVENTS IN SAN DIEGO COUNTY CALIFORNIA. A LINKAGE BETWEEN CARDIOVASCULAR DISTRESS AND MORTALITY WAS SUGGESTED DURING THE INTENSE FIRE SEASON OF 2010 IN EUROPEAN RUSSIA. HOWEVER ONLY A LIMITED NUMBER OF STUDIES HAVE EXAMINED WHETHER CERTAIN SPECIFIC CARDIOVASCULAR AND RESPIRATORY CONDITIONS (HEART FAILURE CARDIOPULMONARY OBSTRUCTIVE DISORDER (COPD) ATRIAL FIBRILLATION AND ASTHMA) ARE ASSOCIATED WITH AIR POLLUTION EXPOSURES AND SPECIFICALLY WITH THOSE RESULTING FROM WILDFIRE OCCURRENCE. THE PROPOSED STUDY WILL FOCUS ON THE SECTION OF THE SOLICITATION AIMED AT EXAMINING THE SOCIETAL IMPACTS OF CHANGES TO ARCTIC AND BOREAL ECOSYSTEMS. IN THIS PROJECT OUR TEAM WILL COMBINE OUR EXPERTISE IN REMOTE SENSING OF FIRE EXTENT AND SEVERITY WILDFIRE EMISSIONS MODELING ATMOSPHERIC TRANSPORT AND SPATIAL EPIDEMIOLOGY TO EXAMINE THE IMPACT OF POPULATION EXPOSURE TO WILDFIRE PM EMISSIONS AND ASSOCIATED HEALTH OUTCOMES BASED ON SATELLITE OBSERVATIONS OF FIRE ACTIVITY AND HOSPITALIZATION RECORDS. AN IMPORTANT ADDITIONAL CONTRIBUTION WILL BE TO IDENTIFY WHETHER CERTAIN SUBPOPULATIONS ARE MORE VULNERABLE TO AIR POLLUTION-RELATED CARDIOVASCULAR AND RESPIRATORY OUTCOMES. IN THIS SUB-GOAL WE WILL EXAMINE THE RELATIVE IMPACT OF WILDFIRE EMISSIONS ON URBAN CENTERS AND INDIGENOUS POPULATIONS. AS POPULATION IN THE STATE OF ALASKA CONTINUES TO GROW AND THE PROJECTED WILDFIRE OCCURRENCE IN LIKELY TO SURPASS PRESENT LEVELS IN THE NEAR FUTURE THE RESULTS OF THIS STUDY WILL HAVE LARGE IMPLICATIONS FOR POLICY DEVELOPMENT AND HEALTHCARE SYSTEM IN ALASKA. .
$811,299University Of Maryland, College Park · · FY2020 · National Aeronautics and Space Administration
Multi-Scale Laws of Myocardial Growth and Remodeling
$811,109Julius Matteo Guccione · University Of California, San Francisco · U01 · FY2014 · HL
Early myocardial remodeling and progressive kidney function decline in type 1 diabetes
$811,054Alessandro Doria · Joslin Diabetes Center · R01 · FY2025 · HL
C1C2 Gene Transfer in CHF
$811,017H. Kirk Hammond · Veterans Medical Research Fdn/San Diego · P01 · FY2016 · HL
C1C2 Gene Transfer in CHF
$811,017H. Kirk Hammond · Veterans Medical Research Fdn/San Diego · P01 · FY2017 · HL
Improving Mitral Compensation in Ischemic Regurgitation
$810,817Robert A Levine · Massachusetts General Hospital · R01 · FY2013 · HL
Preventing Myocardial Events of Aging: A PREVENTABLE Ancillary Study
$810,699Parag Goyal · Weill Medical Coll Of Cornell Univ · R01 · FY2024 · AG
AI-enabled characterization of fibrocalcific aortic valve disease and inflammation from CT Angiography: Patient-specific outcome prediction
$810,650Damini Dey · Cedars-Sinai Medical Center · R01 · FY2024 · HL
'Heart Failure in the Community: Multimorbidity and Outcomes'
$810,466Veronique L Roger · Mayo Clinic Rochester · R01 · FY2014 · HL
Assessment of Mast Cell Degranulation in Infarcted Myocardium Using Quantitative Multiparametric MRI
$810,354Debiao Li · Cedars-Sinai Medical Center · R01 · FY2024 · HL
Engineering Clinical Trials on a Chip for Dystrophin-Deficient Muscular Dystrophy
$810,112Deok-Ho Kim · Johns Hopkins University · UH3 · FY2022 · TR