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38,696 grants matching “als”
Immunology of aging and immunotherapy of aging-associated diseases
$889,306Arya Biragyn · National Institute On Aging · ZIA · FY2014 · AG
Immunoregulation /Immune Recognition In Filarial/Nonfilarial Parasitic Infection
$889,289Thomas Nutman · National Institute Of Allergy And Infectious Diseases · ZIA · FY2013 · AI
Sodium pump inhibitors in blood pressure regulation and in profibrotic signaling in salt sensitive hypertension and aging
$888,748Olga V Fedorova · National Institute On Aging · ZIA · FY2017 · AG
A systems approach to manipulate microbial adaptation to structured environments
$888,728Nitin S Baliga · Institute For Systems Biology · R01 · FY2021 · AI
Initiation of DNA Replication in Mammalian Cells
$888,597Mirit Aladjem · Division Of Basic Sciences - Nci · Z01 · FY2008 · CA
Genetic Discovery and Pathobiology of Frontotemporal Lobar Degeneration and Related TDP-43 Proteinopathies
$888,569Rosa Rademakers · Mayo Clinic Jacksonville · R35 · FY2017 · NS
Genetic Epidemiology of Complex Traits
$888,524Joan E. Bailey-Wilson · National Human Genome Research Institute · ZIA · FY2021 · HG
Development of TIMP-2 derivatives or strategies as biologic therapies for cancer
$888,432William Stetler-Stevenson · Division Of Basic Sciences - Nci · ZIA · FY2023 · CA
Biological Soft X-ray Tomography at the Advanced Light Source
$888,195Carolyn A Larabell · University Of California, San Francisco · P30 · FY2023 · GM
Genomics and Proteomics of Head and Neck Cancer
$887,719Carter Van Waes · National Institute On Deafness And Other Communication Disorders · ZIA · FY2010 · DC
Regulation and function of deubiquitinating enzyme USP19
$887,596Yihong Ye · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2015 · DK
Genomic analysis of bipolar disorder in a genetic isolate
$887,344Maja Bucan · University Of Pennsylvania · R01 · FY2012 · MH
Regulation of mRNA processing: Mechanisms and consequences
$887,320James L. Manley · Columbia Univ New York Morningside · R35 · FY2017 · GM
Signal Transduction Events and the Regulation of Cell Growth
$887,075Jane B Trepel · Division Of Clinical Sciences - Nci · ZIC · FY2012 · CA
WE PROPOSE TO MINIATURIZE AN X-RAY MICROCOMPUTED TOMOGRAPHY (MICROCT) SYSTEM FOR IN SITU ANALYSIS OF LAYERED MARTIAN ICE. THE MICRO IN SITU TOMOGRAPHY SYSTEM (MISTS) WILL PROVIDE THE MICROSTRUCTURAL INFORMATION WE WOULD SEEK FROM AN ICE CORE: MILLIMETER SCALE STRATIGRAPHY OF IMPURITY LAYERS AND MICRON SCALE PARTICLE SIZE SHAPE AND POSITION. OBJECTIVE MARS HAS LAYERED SUBSURFACE ICE AND POLAR LAYERED DEPOSITS THAT CONTAIN A CLIMATE RECORD RELEVANT TO STUDIES OF PAST HABITABILITY AND CLIMATE SCIENCE MORE GENERALLY. MICROCT PROVIDES NON-DESTRUCTIVE THREE-DIMENSIONAL VISUALIZATION AND CHARACTERIZATION OF THE INTERNAL FEATURES OF MULTIPHASE MATERIALS WITH SPATIAL RESOLUTION DOWN TO SEVERAL MICRONS. IT HAS BEEN USED EXTENSIVELY IN THE STUDY OF DEPOSITIONAL PROCESSES IN SEDIMENTARY ROCK (E.G. FALVARD AND PARIS 2017) AND MORE RECENTLY IN ICE (OBBARD ET AL. 2009; IVERSON ET AL. 2017). MICROCT CAN MEASURE MICRON SCALE LAYER STRATIGRAPHY PARTICLE SIZE SHAPE VOLUME CONCENTRATION PORE SIZE SHAPE AND DISTRIBUTION ALL AS A FUNCTION OF DEPTH. THE USE OF MICROCT TO DIFFERENTIATE AND IDENTIFY DEPOSITIONAL LAYERS BASED ON PARTICLE SIZE AND SHAPE DISTRIBUTION IN THE ICE HAS BEEN DEMONSTRATED IN THE WEST ANTARCTIC ICE SHEET (WAIS) CORE WERE USED TO IDENTIFY THE TYPE AND SOURCE OF SPECIFIC VOLCANIC ERUPTIONS (IVERSON ET AL. 2017). APPLICATION OF THE TECHNIQUE HAS BEEN GROWING IN PART DUE TO RAPID ADVANCES IN INSTRUMENTATION TECHNOLOGY AND ACCESSIBILITY THROUGH COMMERCIALLY AVAILABLE BENCHTOP SYSTEMS. TYPICALLY A MICROCT SYSTEM IS LOCATED IN A LABORATORY; HOWEVER IN SOME SITUATIONS IT MAY BE PREFERRED (E.G. TRANSPORT AND CURATION OF FROZEN SAMPLES) TO BRING THE MICROCT TO THE SAMPLES. WE PROPOSE TO DEVELOP A MINIATURIZED MICROCT SYSTEM THAT CAN BE USED ROBOTICALLY TO EXAMINE STRATIGRAPHY AND SEDIMENT DISTRIBUTION IN MARTIAN ICE CORES. TECHNICAL APPROACH THE MISTS WILL BE A TWO-STEP PROCESS. IMMEDIATELY FOLLOWING COLLECTION AN ICE CORE WILL BE PLACED BETWEEN SOURCE AND DETECTOR AND XRAY ATTENUATION IMAGES COLLECTED. ONE OF THE CHALLENGES WE FORESEE IS THE NEED TO WITHDRAW AND IMAGE FRACTURED CORES. THE ICE CORING DRILL WILL EMPLOY HONEYBEE ROBOTICS ECCENTRIC TUBES CORE BREAKOFF AND RETENTION TECHNOLOGY A METAL BIT WITH AN INTERNAL BREAKOFF AND CACHING TUBE(S) MADE OF AN X-RAY TRANSPARENT POLYMER (ZANCY 2014). AS THE CACHING TUBE AND CORE IS DRAWN FROM THE HOLE IT WILL PASS THOUGH A SURFACE MOUNTED MICROCT SYSTEM WHICH WILL IMAGE THE SAMPLE IN SITU IN THE TUBE. DATA (BITMAP X-RAY ATTENUATION IMAGE FILES VERTICAL AND AZIMUTHAL POSITION AND X-RAY SOURCE STATISTICS) WILL BE TRANSFERRED TO EARTH WHERE TOMOGRAPHIC IMAGES WILL BE RECONSTRUCTED. TASKS: 1. DETERMINE OPTIMAL CORE DIAMETER BY WEIGHING COMPETING REQUIREMENTS SUCH AS SAMPLE SIZE TOMOGRAPHIC SPATIAL RESOLUTION DRILLING AND MICROCT POWER AND WEIGHT. 2. SPECIFY X-RAY SOURCE STRENGTH INTEGRATION TIME DETECTOR RESOLUTION. 3. IDENTIFY MICROCT GEOMETRY COMPONENTS (I.E. SOURCE AND DETECTOR) AND DESIGN. 4. MAKE DESIGN CHANGES TO CURRENT CORE BREAKOFF AND RETENTION SYSTEM INCLUDING THE CACHING/ANALYSIS TUBE(S). 5. BUILD AND TEST MICROCT SYSTEM ON CACHING TUBES CONTAINING ICE AND SEDIMENT IN THE LAB AT COLD TEMPERATURES. THE PROPOSED WORK IS RELEVANT TO NASA PICASSO BECAUSE WE AIM TO DESIGN AND DEVELOP A NEW MINIATURIZED INSTRUMENT TO BE USED FOR IN SITU SCIENCE IN A PLANETARY CONTEXT. UNDER THIS PROJECT THE PROPOSED INSTRUMENT WILL ADVANCE FROM TRL 2 TO TRL 4.
$886,590Seti Institute · · FY2020 · National Aeronautics and Space Administration
Institutional Career Development
$886,522Luisa A Dipietro · University Of Illinois At Chicago · KL2 · FY2018 · TR
Human natural killer cells: Advancing biology and clinical applications
$886,438Michael A Caligiuri · Beckman Research Institute/City Of Hope · R35 · FY2025 · CA
Neurocognitive Aging, Epigenetic Contributions
$886,425Peter R Rapp · National Institute On Aging · ZIA · FY2011 · AG
Managing Alpha-1-Antitrypsin Deficiency (AATD) through Proteostasis Signaling Pathways
$886,144William Edward Balch · Scripps Research Institute, The · R01 · FY2024 · HL
Post-transcriptional control of Proliferation, Stress Response & Carcinogenesis
$886,074Myriam Gorospe · National Institute On Aging · ZIA · FY2015 · AG
CANDIDA ADHERENCE MYCOLOGY RESEARCH UNIT
$885,941La Biomed Res Inst/ Harbor Ucla Med Ctr · P01 · FY2001 · AI
Core A -Administrative Core
$885,911Jerome A. Zack · University Of California Los Angeles · P30 · FY2025 · AI
Biological Soft X-ray Tomography at the Advanced Light Source
$885,675Carolyn A Larabell · University Of California, San Francisco · P30 · FY2022 · GM
Novel Formulations for Injectable Growth Factors
$885,635Bruce Lamb · Affinergy ,Inc · R44 · FY2010 · DE
Discovery And Functional Genomics Of Environmental Response Genes
$885,236Douglas Bell · National Institute Of Environmental Health Sciences · ZIA · FY2023 · ES