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38,696 grants matching “als”
Structure and Function of UDP-GalNAc:polypeptide alpha-GalNAc transferases
$911,879Lawrence A. Tabak · National Institute Of Dental & Craniofacial Research · ZIA · FY2017 · DE
fMRI Study of Cognition, Motivation, Decision-Making, Reward, Risk, Aversion, Craving, impulsivity, and Stress in Alcohol Use Disorder
$911,260Abdolreza Momenan · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2019 · AA
In vivo studies of neural system in zebrafish
$911,200Fumihito Ono · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2013 · AA
DEVELOPMENT OF PEG10 INHIBITORS IN THE FIGHT AGAINST ALS-FTD
$911,151The Regents Of The University Of Colorado · · FY2025 · Defense Health Agency
A type 2 hybrid effectiveness-implementation trial to evaluate a population health combination intervention to meet HIV testing, linkage, and viral suppression goals in coastal Alabama
$909,741Aadia Rana · University Of Alabama At Birmingham · R01 · FY2024 · AI
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
$909,647University Of Chicago · · FY2020 · National Aeronautics and Space Administration
Patterns and Predictors of Smoking from Adolescence to Young Adulthood
$909,358Robin J Mermelstein · University Of Illinois At Chicago · P01 · FY2011 · CA
Exploring Cognitive Aging Using Reference Ability Neural Networks
$909,186Yaakov Stern · Columbia University Health Sciences · R01 · FY2013 · AG
Pharmacology and toxicology of newly-emerging designer drugs of abuse
$909,120Amy Hauck Newman · National Institute On Drug Abuse · ZIA · FY2014 · DA
Phase II I/UCRC Colorado School of Mines Site: Center for Advanced Non-Ferrous Structural Alloys (CANFSA)
$908,990Amy Clarke · Colorado School Of Mines · · FY2016 · ENG
The Neural Foundations for Memory and Social Cognition In The Human Brain
$907,757Alex Martin · National Institute Of Mental Health · ZIA · FY2018 · MH
The Cognitive Neuroscience of Autism Spectrum Disorders
$907,757Alex Martin · National Institute Of Mental Health · ZIA · FY2018 · MH
Genetic Analysis of Attention Deficit Hyperactivity Disorder
$907,736Maximilian Muenke · National Human Genome Research Institute · ZIA · FY2009 · HG
Genetics of Brain Development
$907,736Maximilian Muenke · National Human Genome Research Institute · ZIA · FY2009 · HG
In vivo CRISPR engineering of B cells to produce anti-HIV broadly neutralizing antibodies using novel nanoparticles
$907,227Jennifer Eileen Adair · Fred Hutchinson Cancer Center · R01 · FY2023 · AI
The study of stem cell and neuro-vascular development
$907,085Yosuke Mukoyama · National Heart, Lung, And Blood Institute · ZIA · FY2019 · HL
Development and modification of neural circuitry in the mammalian olfactory bulb
$907,051Leonardo Belluscio · National Institute Of Neurological Disorders And Stroke · ZIA · FY2013 · NS
Restoration of olfactory neural circuitry following disruption.
$907,051Leonardo Belluscio · National Institute Of Neurological Disorders And Stroke · ZIA · FY2013 · NS
Nicotinic ligands for smoking cessation
$906,607Henry A. Lester · California Institute Of Technology · U19 · FY2009 · DA
Pre-clinical and clinical studies of NTBC and other compounds as potential treatments for albinism
$906,077Brian Brooks · National Eye Institute · ZIA · FY2019 · EY
Harnessing the power of exosomes for non-coding RNA delivery
$905,873Anil K Sood · University Of Tx Md Anderson Can Ctr · R35 · FY2018 · CA
Pharmacology and toxicology of newly-emerging designer drugs of abuse
$905,544Amy Hauck Newman · National Institute On Drug Abuse · ZIA · FY2015 · DA
Effects of Expanded Coverage on Access, Health Care and Health in the South
$905,487John A. Graves · Vanderbilt University Medical Center · R01 · FY2015 · CA
Preclinical medication development for stimulant use disorder
$905,309Michael Baumann · National Institute On Drug Abuse · ZIA · FY2025 · DA
Genetic etiology of Amyotrophic Lateral Sclerosis
$905,307Bryan Traynor · National Institute On Aging · ZIA · FY2018 · AG