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24,576 grants matching “microbiome”
Investigating genomic factors and microbiome features that impact CDI transmission and prognosis
$847,495Harm Van Bakel · Icahn School Of Medicine At Mount Sinai · R01 · FY2017 · AI
Investigating genomic factors and microbiome features that impact CDI transmission and prognosis
$847,495Harm Van Bakel · Icahn School Of Medicine At Mount Sinai · R01 · FY2019 · AI
Methods development for "Omics" data
$847,292Alison Motsinger-Reif · National Institute Of Environmental Health Sciences · ZIA · FY2022 · ES
Multi-omics characterization of HIV-associated changes in the gut microbiome and host mucosal immunity
$846,940Douglas Kwon · Massachusetts General Hospital · R01 · FY2021 · DK
Multi-omics characterization of HIV-associated changes in the gut microbiome and host mucosal immunity
$846,940Douglas Kwon · Massachusetts General Hospital · R01 · FY2022 · DK
Activation of probiotic bifidobacteria by milk glyans
$846,787David Andrew Mills · University Of California At Davis · R01 · FY2017 · AT
Development of a companion diagnostic to identify patients who respond to microbiome-targeting drugs
$846,715Bret David Wallace · Symberix, Inc. · R44 · FY2021 · GM
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SOIL MICROBIOMES OFFER MAJOR OPPORTUNITIES TO INCREASE SOIL CARBON, IMPROVE SOIL HEALTH, AND ENSURE THE SUSTAINABILITY OF DRYLAND SYSTEMS. HOWEVER, IN DRYLANDS OF THE SOUTHWESTERN USA, THERE ARE FEW AVENUES TO INCORPORATE KNOWLEDGE OF THE SOIL MICROBIOME AND PLANT-MICROBE INTERACTIONS INTO MANAGEMENT PLANS. MEANWHILE, IN THESE ARID AND SEMI-ARID ECOSYSTEMS, THE ADDITIVE EFFECTS OF LAND- USE INTENSIFICATION (GRAZING), CLIMATE CHANGES (E.G., INCREASING DROUGHT EVENTS), AND INCREASED SOIL EROSION CREATE A THREATENING SELF-REINFORCING CYCLE THAT WILL INHIBIT THESE SOILS TO EFFECTIVELY PRODUCE FOOD, SEQUESTER CARBON, AND SUPPORT OTHER ECOSYSTEMS SERVICES IN THE FUTURE. MECHANISTIC STUDIES ARE NEEDED THAT WILL 1) ASSESS HOW SOIL MICROBIAL DIVERSITY, COMPOSITION, AND FUNCTIONS VARY ACROSS HETEROGENEOUS RANGELANDS IN THE SOUTHWESTERN USA, 2) QUANTIFY THE IMPACTS OF COMBINED LAND-USE AND CLIMATE CHANGE, AND 3) PROVIDE REALISTIC MANAGEMENT SOLUTIONS FOR FUTURE RESTORATION AND CONSERVATION EFFORTS. HERE WE PROPOSE A STUDY THAT WILL TEST FOR THE INTERACTING EFFECTS OF CLIMATE CHANGE AND LAND-USE ON SOIL MICROBIAL FUNCTIONS, PLANT PRODUCTIVITY, AND CARBON STORAGE ACROSS THE SONORAN AND CHIHUAHUAN DESERTS. USING NOVEL MICROBIOME ANALYSES, COMBINED WITH AN ARID- FOCUSED SOIL HEALTH ASSESSMENT FRAMEWORK, AND INNOVATIVE GREENHOUSE EXPERIMENTS WE WILL QUANTIFY THE GENOMIC AND FUNCTIONAL VARIABILITY OF THE SOIL MICROBIOME ACROSS DRYLAND ECOSYSTEMS AND ADVANCE THE BASIC UNDERSTANDING OF MICROBIAL CONTROLS ON CARBON POOLS IN DRYLANDS UNDER GLOBAL CHANGE PRESSURES. WE WILL THEN IDENTIFY SCENARIOS IN WHICH PLANT-MICROBE INTERACTIONS AND CONSORTIA OF SOIL MICROBES CAN BE LEVERAGED IN LAND MANAGEMENT TO RESIST INCREASING DROUGHT REGIMES AND INCREASE SOIL CARBON UNDER DIFFERENT LAND-USES.
$846,562The University Of Texas At El Paso · · FY2024 · National Institute of Food and Agriculture
Targeting microbial triggers of gammopathy for immunoprevention
$846,118Madhav V Dhodapkar · Fred Hutchinson Cancer Center · UG3 · FY2025 · CA
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** YELLOW STARTHISTLE (CENTAUREA SOLSTITIALIS) IS A MAJOR WEED OF WESTERN RANGELANDS IN THE UNITED STATES, CAUSING SEVERE ECONOMIC AND ECOLOGICAL HARM. EFFORTS TO CONTROL ITS INVASIONS HAVE NOT BEEN SUCCESSFUL TO DATE, AND THE PLANT HAS EVOLVED INCREASED GROWTH AND SEED PRODUCTION IN THESE POPULATIONS, FURTHER EXACERBATING THE PROBLEM. WE HAVE FOUND LARGE DIFFERENCES IN THE MICROBIAL COMMUNITIES ASSOCIATED WITH THIS WEED ACROSS ITS RANGE, AND EVIDENCE THAT THE MICROBIOME CAN ALTER WEED PERFORMANCE. THIS RESEARCH WILL EXPLORE THE POSSIBILITY THAT SOIL MICROBES FROM WITHIN THE WESTERN UNITED STATES COULD BE USED TO HINDER YELLOW STARTHISTLE INVASIONS AND SIMULTANEOUSLY INCREASE THE SUCCESS OF VALUABLE FORAGE GRASSES, ALL WHILE AVOIDING RISKS ASSOCIATED WITH IMPORTING BIOCONTROL AGENTS FROM OTHER CONTINENTS.OUR WORK BEGINS BY FORMING COLLABORATIONS WITH RANCHERS WHO ARE DEALING WITH YELLOW STARTHISTLE INVASIONS ON THE GROUND. WE WILL WORK WITH THESE COLLABORATORS TO IDENTIFY SITES IN NEED OF CONTROL AND TO COLLECT SEEDS AND MICROBES FROM THESE AREAS. THESE SEEDS AND MICROBIAL COLLECTIONS WILL BECOME PART OF OUR EXPERIMENTS. OUR EXPERIMENTS WILL ALSO INCLUDE MICROBIAL COMMUNITIES THAT WE HAVE BEEN SELECTING FOR THEIR ABILITY TO REDUCE THE GROWTH OF YELLOW STARTHISTLE. WE WILL COMPARE THE EFFECTS OF THESE DIFFERENT MICROBIOMES ON YELLOW STARTHISTLE PERFORMANCE, AND ON STARTHISTLE'S COMPETITIVE EFFECTS ON A DESIRABLE FORAGE GRASS. WE WILL IDENTIFY THE MICROBES INVOLVED IN DIFFERENT OUTCOMES, AND EXAMINE HOW THE GENETIC MAKEUP OF THE PLANTS AFFECT THEIR PERFORMANCE IN OUR EXPERIMENTS. TOGETHER, THIS WORK WILL ADVANCE OUR ULTIMATE GOAL TO UNDERSTAND WHETHER MICROBES COULD BE LEVERAGED FOR CONTROL OF YELLOW STARTHISTLE, AND TO LAY A FOUNDATION FOR TESTING OUR SOLUTIONS IN THE REAL WORLD.?
$845,800University Of Arizona · · FY2023 · National Institute of Food and Agriculture
CAMPO Clinical Trials Program
$845,784Joel Palefsky · University Of California, San Francisco · U54 · FY2020 · CA
The Role of Secondary Bile Acids in Gastro-Esophageal Neoplasia
$845,100Julian Abrams · Columbia University Health Sciences · R01 · FY2022 · CA
Targeting NuoD for the treatment of H. pylori
$844,980Richard Edward Lee · St. Jude Children'S Research Hospital · R01 · FY2024 · AI
Targeting NuoD for the treatment of H. pylori
$844,980Richard Edward Lee · St. Jude Children'S Research Hospital · R01 · FY2025 · AI
The MetaCyc & BioCyc Pathway/Genome Databases (SRI Proposal ECU 14-630)
$844,698Peter D Karp · Sri International · R01 · FY2017 · GM
Airway dual-transcriptomics in bronchiolitis and risk of asthma: MARC-35 cohort
$843,082Kohei Hasegawa · Massachusetts General Hospital · R01 · FY2019 · AI
Ultra-processed Foods, Diet Quality, and Cardiometabolic Health: An Inter-disciplinary Trans-Atlantic Collaborative Project
$843,047Qi Sun · Harvard University D/B/A Harvard School Of Public Health · R01 · FY2025 · DK
Constrained Statistical Inference
$842,074Shyamal Peddada · National Institute Of Environmental Health Sciences · ZIA · FY2025 · ES
Impact of Sugars and Human Milk Oligosaccharides on Infant Microbiome and Obesity
$841,950Michael I Goran · Children'S Hospital Of Los Angeles · R01 · FY2020 · DK
Activation of probiotic bifidobacteria by milk glyans
$841,763David Andrew Mills · University Of California At Davis · R01 · FY2018 · AT
Mechanisms that Predict Weight Trajectory after Bariatric Surgery: The Interactive Roles of Behavior and Biology
$841,522Kristine Jayne Steffen · North Dakota State University · R01 · FY2017 · DK
Microbial biomarkers of intestinal MDR colonization after solid organ transplantation
$841,520Anne-Catrin Uhlemann · Columbia University Health Sciences · R01 · FY2025 · AI
Nasal biomarkers of asthma
$841,388Supinda Bunyavanich · Icahn School Of Medicine At Mount Sinai · R01 · FY2017 · AI
Genetic Epidemiology
$839,884Alisa Goldstein · Division Of Cancer Epidemiology And Genetics · ZIA · FY2018 · CA
Biomarkers of Chlamydial Susceptibility and Disease
$839,721Catherine M O'Connell · Univ Of North Carolina Chapel Hill · U19 · FY2023 · AI