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24,576 grants matching “microbiome”
Molecular characterization of the role for metabolites in immune cell differentiation
$854,834Amy Susan Weinmann · University Of Chicago · R01 · FY2025 · AI
A Foundation for the Oral Microbiome and Metagenome
$854,601Floyd E Dewhirst · Ada Forsyth Institute, Inc. · R37 · FY2012 · DE
Flaxseed effects on hormones and lignans: role of race, genes, and gut microbiome
$854,101Susan E McCann · Roswell Park Cancer Institute Corp · U01 · FY2014 · CA
CAREER: Designing Synthetic Anaerobic Consortia for Bioproduction
$853,101Michelle A O'Malley · University Of California-Santa Barbara · · FY2016 · BIO
Understanding Mechanisms and Sex-Differences in Visceral Pain
$852,896Holly A. Ingraham · University Of California, San Francisco · R01 · FY2025 · DK
Microbiome, metabolites, and alcohol in HIV to reduce CVD RCT (META HIV CVD RCT)
$852,599Matthew S Freiberg · Vanderbilt University Medical Center · P01 · FY2023 · AA
Viral persistence & the microbiome in bronchiolitis and risk of recurrent wheeze
$852,079Jonathan M Mansbach · Boston Children'S Hospital · R01 · FY2015 · AI
Effect of infant antibiotics on the development of the early-life airway and gut microbiome and risk of childhood asthma
$852,028Christian Rosas-Salazar · Vanderbilt University Medical Center · R01 · FY2025 · HL
Towards Precision Nutrition for Alzheimer's Dementia Prevention: A Prospective Study of Dietary Patterns, the Gut Microbiome and Cognitive Function
$851,108Dong Wang · Brigham And Women'S Hospital · R01 · FY2025 · AG
Collaborative Research: The interplay between host diet, immunity, reproduction, and the microbiome across an anthropogenic-disturbed landscape
$850,845Susannah S French · Utah State University · · FY2018 · BIO
Integrated genomics research in parasitic tropical diseases
$850,797Joana Carneiro Da Silva · University Of Maryland Baltimore · U19 · FY2018 · AI
Activation of probiotic bifidobacteria by milk glyans
$850,712David Andrew Mills · University Of California At Davis · R01 · FY2016 · AT
CAMPO Clinical Trials Program
$850,637Joel Palefsky · University Of California, San Francisco · U54 · FY2021 · CA
Fragile Families: The Third Generation
$850,427Julien O Teitler · Columbia Univ New York Morningside · R01 · FY2021 · HD
Clinical Core
$850,199Daniel W Fitzgerald · Weill Medical Coll Of Cornell Univ · U19 · FY2014 · AI
Sample Repository for Human Genetic Research
$850,000Alissa Marie Resch · Coriell Institute For Medical Research · U41 · FY2017 · HG
Sample Repository for Human Genetic Research
$850,000Alissa Marie Resch · Coriell Institute For Medical Research · U41 · FY2019 · HG
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PLANT MICROBIOMES, THE MICROBES THAT LIVE IN AND ON PLANTS, HOLD PROMISE FOR SUSTAINABLE DISEASE PROTECTION IN CROPS THREATENED BY SERIOUS PANDEMIC DISEASES. ALTHOUGH RESEARCH HAS REVEALED MANY ISOLATED BENEFICIAL MICROBES, EACH PLANT LIKELY HOSTS THOUSANDS OF DIFFERENT MICROBES THAT MAY WORK TOGETHER TO COOPERATIVELY PROTECT PLANTS. THIS PROJECT FOCUSES ON MICROBIOMES IN BANANA (GENUS MUSA), WHICH IS ONE OF THE MOST GLOBALLY VALUABLE FRUITS. COMMERCIALLY, BANANAS ARE AMONG THE HIGHEST PRODUCTION GLOBAL CROPS, AFTER WHEAT, RICE, MAIZE, AND SOYBEANS. THEY ARE THE TOP FRUIT COMMODITY GLOBALLY, PRODUCED IN 130 COUNTRIES AND VALUED AT US$44 BILLION. ABOUT 85% OF BANANAS AND PLANTAINS SERVE AS A STAPLE FOOD OR SUPPORT LOCAL ECONOMIES, PARTICULARLY IN DEVELOPING ECONOMIES. HOWEVER, PANDEMIC PLANT DISEASES LIKE PANAMA DISEASE, WHICH IS CAUSED BY THE FUNGUS FUSARIUM OXYSPORUM F. SP. CUBENSE RACE 4 (FOC TR4), ARE A MAJOR THREAT TO FOOD SECURITY. CURRENT PREDICTIONS ARE THAT THIS FUNGUS WILL DECIMATE THE LEADING CAVENDISH CULTIVAR, IN THE NEAR FUTURE, WITHOUT ALTERNATIVE STRATEGIES TO IMPROVE RESISTANCE. THEREFORE, THE MAJOR GOAL OF THIS PROJECT IS TO INVESTIGATE DISEASE-PROTECTIVE SYNERGISTIC PROCESSES HIDDEN IN THE BANANA PLANT'S MICROBIOME, TO LAY THE FOUNDATIONS FOR SUSTAINABLE DISEASE CONTROL. DATA SHOW THAT DIFFERENT BANANA VARIETIES AND DIFFERENT CULTIVATION HISTORIES AFFECT DISEASE-PROTECTIVE MICROBIOMES. HOWEVER, TO DATE, MOLECULAR ANALYSES HAVE BEEN LIMITED, WITH FEW WHOLE-COMMUNITY STUDIES. THE PROJECT OBJECTIVES ARE TO FIRST CHARACTERIZE HOW MICROBIOMES AND PLANTS FORM METABOLIC SYNERGISMS, AND HOW THESE VARY ACROSS BANANA VARIETIES AND DIFFERENT TISSUES FROM ROOTS TO LEAVES. THEN, WE SEEK TO DIRECTLY TEST THE ANTI-FUNGAL (I.E., ANTI-FOC) SYNERGISTIC PROCESSES BY TRANSFERRING MICROBIOMES BETWEEN RESISTANT AND SUSCEPTIBLE PLANTS, BOTH IN PETRI PLATE CULTURES AND IN GREENHOUSE PLANTS. THE CENTRAL HYPOTHESIS IS THAT LESS CULTIVATED BANANA PLANTS WILL HAVE THE GREATEST MICROBIOME METABOLIC NETWORK COMPLEXITY AND SYNERGISTIC DISEASE-PROTECTIVE FUNCTIONS. RESULTS WILL BE COMMUNICATED TO THE AGRICULTURAL RESEARCH COMMUNITIES, INCLUDING STUDENT TRAINEES, THROUGH HIGH-IMPACT PUBLICATIONS, CONFERENCE PRESENTATIONS, AND IN TEACHING GRADUATE AND UNDERGRADUATE STUDENTS. OUR PROJECT WILL ALSO TRAIN A POSTDOC, A PHD STUDENT, AND UNDERGRADUATES TO BE LEADERS IN THE STUDY OF AGRICULTURAL MICROBIOMES. WE EXPECT TO DEVELOP NEW METHODS, SUCH AS MICROBIOME ENRICHMENT, MICROBIOME TRANSFER BY INJECTION, AND NEW ANALYSIS METHODS. THE ULTIMATE GOAL IS TO UNCOVER DIVERSE AND NOVEL SYNERGIES AND BIOACTIVITIES THAT WILL SET THE GROUNDWORK FOR DEVELOPMENT OF SUSTAINABLE MICROBIOME-BASED STRATEGIES FOR DISEASE MANAGEMENT THAT MAY BE RELEVANT TO A WIDE RANGE OF CROP SYSTEMS. SPECIFIC TO BANANA, GIVEN THE IMMINENT DISEASE THREATS TO CAVENDISH, AND ITS IMPORTANCE AS A TRADE COMMODITY AND SOURCE OF GLOBAL FOOD SECURITY, OUR PROJECT OUTCOMES HAVE POTENTIAL FOR ENORMOUS IMPA,CT THAT WILL INFORM MODERN SUSTAINABLE BIOCONTROL AND BIOFORTIFICATION TECHNOLOGIES FOR THIS PLANT. THIS FOCUS ALIGNS WITH THE GOAL OF REDUCING USE OF CHEMICALS (PESTICIDES, ANTIBIOTICS, AND BIOCIDES) IN BANANA PRODUCTION, AND LEAD TO THE DEVELOPMENT OF SAFER ALTERNATIVES.
$850,000Texas Tech University System · · FY2024 · National Institute of Food and Agriculture
Sample Repository for Human Genetic Research
$850,000Laura Scheinfeldt · Coriell Institute For Medical Research · U41 · FY2020 · HG
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** GROWING HUMAN POPULATION AND CLIMATE CHANGE NECESSITATE SUSTAINABLE SOLUTIONS THAT REDUCE OUR RELIANCE ON AGROCHEMICALS, WHILE INCREASING AGRICULTURAL PRODUCTIVITY. PLANT GROWTH-PROMOTING RHIZOBACTERIA IS A SUSTAINABLE APPROACH TO INCREASE CROP YIELDS. HOWEVER, THE UNKNOWN INTERACTIONS AMONG THE PLANT HOST, ENVIRONMENT, AND MICROBES CREATE CHALLENGES FOR THE SUPPLEMENTATION AND PERSISTENCE OF DESIRABLE AGRICULTURAL MICROBIOMES WITH ROBUST PLANT BENEFITS.THE OVERARCHING GOAL OF THIS PROJECT IS TO OPTIMIZE AGRICULTURAL MICROBIOMES VIA PLANT ROOT EXUDATE ENGINEERING FOR SUSTAINABLE IMPROVEMENT OF CROP YIELDS, FOCUSING ON NUTRIENT USE EFFICIENCY. WE WILL FIRST IDENTIFY SPECIFIC PLANT-BACTERIA COMMUNICATION MOLECULES WITH DETERMINISTIC INFLUENCE OVER SOIL MICROBIAL COMMUNITY ASSEMBLY MITIGATING PLANT NUTRIENT STRESS. TO UNDERSTAND THE SIGNAL EXCHANGE INVOLVED IN PLANT MICROBIOME ASSEMBLY, WE WILL DEVELOP HIGH-THROUGHPUT TOOLS FOR TESTING BACTERIA CHEMOTAXIS AND GROWTH. NEXT, WE WILL ELUCIDATE HOW THESE MOLECULES INFLUENCE BACTERIAL INTERSPECIES COMPETITION AND COMMUNITY DYNAMICS IN AGRICULTURAL SOILS VIA MULTI-OMICS. LASTLY, WE WILL CHARACTERIZE THE FUNCTIONALITY OF THE ENRICHED MICROBIOME TO CONFER INCREASED PLANT NUTRIENT USE EFFICIENCY, INFORMING FUTURE PLANT BREEDING AND ENGINEERING EFFORTS.OUR INTERDISCIPLINARY TEAM WITH CROSS-CUTTING EXPERTISE IN CHEMISTRY AND PLANT BIOENGINEERING (DEMIRER), MICROBIOLOGY (NEWMAN), AND SOIL MULTI-OMICS (KARTHIKEYAN) WILL FILL MAJOR KNOWLEDGE GAPS IN AGRICULTURAL MICROBIOMES, ALLEVIATE CHALLENGES ASSOCIATED WITH BIOFERTILIZERS, AND REDUCE OVERALL NEGATIVE IMPACTS OF AGRICULTURE.
$850,000California Institute Of Technology · · FY2024 · National Institute of Food and Agriculture
Sample Repository for Human Genetic Research
$850,000Alissa Marie Resch · Coriell Institute For Medical Research · U41 · FY2018 · HG
Sample Repository for Human Genetic Research
$850,000Alissa Marie Resch · Coriell Institute For Medical Research · U41 · FY2016 · HG
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** LEAF MICROBIOMES ARE AFFECTED BY THE PLANTS THEY INHABIT AND THE ENVIRONMENT, AND EVEN SMALL CHANGES IN THE MICROBIOME COMPOSITION CAN IMPACT PLANT FITNESS. HOWEVER, LITTLE IS KNOWN ABOUT HOW PLANTS CONTROL THEIR MICROBIOME DURING DISEASE OR DEFENSE RESPONSES, OR HOW THE ASSEMBLED MICROBIOME INFLUENCES PLANT HEALTH. THIS KNOWLEDGE IS PARAMOUNT FOR PROMOTING CROP RESILIENCE IN THE FACE OF INCREASING ENVIRONMENTAL STRESSES. OUR LONG-TERM GOAL IS TO UNDERSTAND HOW THE PLANT IMMUNE SYSTEM REGULATES ASSEMBLY OF THE LEAF MICROBIOME, AND HOW THAT MICROBIOME, IN TURN, MODULATES THE HOST IMMUNE SYSTEM TO RESIST PATHOGENS. IN THIS PROPOSAL, WE USE THE RICE/BACTERIAL BLIGHT (BB) SYSTEM AS A MODEL TO ADDRESS HOW PLANTS SHAPE THEIR MICROBIOMES DURING BIOTIC STRESSES. OUR AIMS ARE TO (1) IDENTIFY RICE GENES THAT INFLUENCE LEAF MICROBIOME ASSEMBLAGE DURING SUSCEPTIBLE AND RESISTANT INTERACTIONS; (2) VALIDATE THE FUNCTION OF CANDIDATE GENES ORCHESTRATING THE ASSEMBLY OF THE RICE MICROBIOME, AND (3) IDENTIFY PLANT AND MICROBIAL MARKERS FOR ENHANCED PLANT RESISTANCE. OVERALL, THE PROPOSED RESEARCH WILL PROVIDE IN-DEPTH UNDERSTANDING OF HOW PLANTS UNDERGOING BIOTIC STRESSES GUIDE LEAF MICROBIOME ASSEMBLY AND HOW THE LEAF MICROBIOME CAN HELP PLANTS DEFEND THEMSELVES FROM DISEASE STRESSES. ULTIMATELY, OUR STUDY WILL PAVE THE WAY FOR IMPROVED RICE BREEDING TO ENSURE A HEALTHY MICROBIOME THAT WILL MAXIMIZE RICE YIELD AND MINIMIZE LOSSES DUE TO DISEASES, ENSURING FOOD SECURITY FOR MILLIONS GLOBALLY.
$849,999Colorado State University · · FY2024 · National Institute of Food and Agriculture
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** HIGH-INTENSITY SPECIALTY FRUIT AND VEGETABLE CROP PRODUCTION DEPEND ON FUMIGATION TO REDUCE DISEASE, NEMATODE, AND WEED PRESSURE PRIOR TO PLANTING. WHILE THE IMPACTS OF FUMIGANTS ON TARGETED SOILBORNE PATHOGENS ARE WELL DOCUMENTED, THEY CAN ALSO IMPACT THE ABUNDANCE AND DIVERSITY OF NON-TARGET SOIL MICROORGANISMS. AS THE SOIL MICROBIOME IS A CRITICAL COMPONENT OF AGRICULTURAL PRODUCTION, THE BROAD MODES OF ACTION OF FUMIGATION COULD INFLUENCE CROP PRODUCTION BY REDUCING ABUNDANCES OF CRITICAL PLANT-GROWTH-PROMOTING ORGANISMS PROVIDING NUTRIENT AVAILABILITY AND NATURAL BIOCONTROL. HOWEVER, WHILE GENERAL RESPONSES OF SOIL MICROBIAL DIVERSITY TO FUMIGATION HAVE BEEN EXAMINED, THERE IS LIMITED INFORMATION REGARDING THE IMPACTS TO SOIL MICROBIOME FUNCTIONS, PARTICULARLY AS THEY RELATE TO CROP PRODUCTION, OVER MULTIPLE GROWING SEASONS, AND IN DIFFERENT SOIL ENVIRONMENTS.THIS PROJECT WILL ASSESS THE INTERACTIONS BETWEEN FUMIGANTS, THE SOIL MICROBIOME, WITH A FOCUS ON PLANT-GROWTH-PROMOTING BACTERIA INVOLVED IN NITROGEN CYCLING AND BIOCONTROL, AND THE IMPACTS ON CROP PRODUCTION. FIELD TRIALS WILL BE ESTABLISHED IN UNIVERSITY AND COMMERCIAL FARMS. TRIALS AT THE UNIVERSITY FARM WILL FOCUS ON DETERMINING SHORT- AND LONG-TERM IMPACTS ON THE SOIL MICROBIOME COMPOSITION AND FUNCTION DUE TO DIFFERENT FUMIGANT MIXTURES. TRIALS AT COMMERCIAL FARMS WILL EXAMINE THE INFLUENCE OF SOIL ENVIRONMENT AND MANAGEMENT PRACTICES ON FUMIGANT IMPACTS TO SOIL MICROBIOME FUNCTIONS.OUR PROJECT WILL HELP FILL MAJOR KNOWLEDGE GAPS IN CHARACTERIZING AGRICULTURAL MICROBIOMES AND MICROBIOME FUNCTIONS ACROSS AGRICULTURAL PRODUCTION SYSTEMS BY FUNCTIONALLY CHARACTERIZING MICROBIOMES THAT MAY BE IMPACTED BY FUMIGATION AND INFLUENCE PROCESSES THAT ARE CRITICAL FOR CROP PRODUCTION, INCLUDING NUTRIENT CYCLING AND PEST AND DISEASE CONTROL.
$849,936University Of Florida · · FY2022 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** CLIMATE CHANGE INDUCES EXTREME ABIOTIC STRESSES SUCH AS DROUGHT AND SALINITY, WHICH ARE DETRIMENTAL TO AGRICULTURAL PRODUCTION. PLANTS NATIVE TO DROUGHT AND SALINITY STRESS-AFFECTED REGIONS CAN THRIVE IN THOSE CONDITIONS DUE TO THE INTERACTIONS WITH THEIR RHIZOSPHERE, A RICH HABITAT OF VARIOUS MICROBES THAT DIRECTLY OR INDIRECTLY AFFECT PLANT GROWTH AND DEVELOPMENT. THE INTERMOUNTAIN WEST REGION IN THE US IS RICH IN DROUGHT-TOLERANT NATIVE PLANTS AND RECOMMENDED FOR LOW-WATER LANDSCAPE PLANTS. NATIVE PLANTS IN THIS REGION HAVE FORMED SYMBIOTIC RELATIONSHIPS WITH NATIVE WILDLIFE OVER THOUSANDS OF YEARS AND OFFER THE MOST SUSTAINABLE HABITAT. ALTHOUGH MANY PLANT GROWTH-PROMOTING BACTERIA (PGPB) ISOLATED FROM PLANT RHIZOSPHERES ARE USED AS SUCCESSFUL BIOFERTILIZERS, NATIVE PLANTS HAVE NOT BEEN EXPLORED FOR THEIR MICROBIOME. ONE WAY TO MEET THE INCREASING FOOD DEMAND DUE TO THE ESCALATING WORLD POPULATION IS BY EXPLORING THE MICROBIOME OF NATIVE PLANTS THAT HELPS THEM ESTABLISH AND SURVIVE IN THEIR HABITAT. THE PROPOSED PROJECT WILL INVESTIGATE THE MICROBIOME OF TWO NATIVE PLANTS,CEANOTHUS VELUTINUS(SNOWBRUSH),CERCOCARPUS LEDIFOLIUS(MOUNTAIN MAHOGANY), OF THE INTERMOUNTAIN WEST REGION OF THE US, AND PLANTS FROM THE GREAT SALT LAKE. THE STUDY WILL THEN ISOLATE, PURIFY, CHARACTERIZE THE RHIZOSPHERE BACTERIA, AND TEST THEM FOR PLANT GROWTH PROMOTION UNDER ABIOTIC STRESSES ON THE MODEL PLANT ARABIDOPSIS. SELECTED PGPB WILL BE CHARACTERIZED FURTHER BY WHOLE GENOME SEQUENCING AND WILL BE VALIDATED ON SELECTED GRAIN (MAIZE AND WHEAT), VEGETABLE (ONION AND WATERMELON), AND FORAGE (ALFALFA) CROPS. THE NATURAL MICROBIOME OF NATIVE PLANTS WILL HELP MITIGATE CROP YIELD REDUCTIONS CAUSED BY ABIOTIC STRESSES.
$849,928Utah State University · · FY2023 · National Institute of Food and Agriculture