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17,828 grants matching “crispr”
Ocular Gene Therapy
$689,405Zhijian Wu · National Eye Institute · ZIA · FY2017 · EY
Mechanisms and therapeutic implications of human clonal hematopoiesis (CH) mutations
$689,125Eirini Papapetrou · Icahn School Of Medicine At Mount Sinai · R01 · FY2022 · CA
Post-transcriptional genome regulation in bacteria with next generation CRISPR-Cas tools
$689,062Jesse Zalatan · University Of Washington · · FY2022 · BIO
Cellular dissection of herpes simplex encephalitis with iPS cells
$688,969Jean-Laurent Casanova · Rockefeller University · R01 · FY2015 · NS
Defining the role of cytomegalovirus in glioblastoma therapies
$688,910Sean Edward Lawler · Brown University · R01 · FY2022 · CA
Mapping the Cerebellar Origins of Medulloblastoma Subgroups
$688,762Paul Northcott · St. Jude Children'S Research Hospital · R01 · FY2025 · CA
Understanding and targeting molecular and cellular events responsible for pulmonary arteriovenous malformation development, growth and regression
$688,595Edda Frauke Spiekerkoetter · Stanford University · R01 · FY2024 · HL
Identification and Characterization of Loci Associated with Non-alcoholic Fatty Liver Disease
$688,575Nicholette D. Allred · Wake Forest University Health Sciences · R01 · FY2022 · DK
Neurotoxicity of particulate matter and its interaction with APOE in neurodegeneration
$688,560Masashi Kitazawa · University Of California-Irvine · R01 · FY2025 · NS
A high-performance and versatile technology for precision microbiome engineering
$688,498Harris H Wang · Columbia University Health Sciences · R01 · FY2021 · EB
Adenine Base Edited Correction of Cystic Fibrosis Airways
$688,492Patrick L Sinn · University Of Iowa · R01 · FY2025 · HL
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** BY CONSUMING CROP PLANTS, HERBIVORES (WHICH ARE ANIMALS THAT FEED ON PLANT TISSUES) CAUSE MAJOR LOSSES IN CROP YIELDS, WHICH IN TURN NEGATIVELY IMPACTS FARMERS AND HUMAN WELFARE MORE GENERALLY. HERBIVORES ARE DIVERSE AND INCLUDE INSECTS LIKE CATERPILLARS AND APHIDS THAT DAMAGE A RANGE OF DICOT CROP PLANTS (LIKE SOYBEAN AND TOMATO) AS WELL AS CEREAL CROP PLANTS (LIKE MAIZE, WHEAT, BARLEY, AND SORGHUM). WHILE MANY INSECT HERBIVORES HAVE BEEN EXTENSIVELY STUDIED, LESS IS KNOWN ABOUT SPIDER MITE PESTS OF CROPS PLANTS. SPIDER MITES ARE ONLY DISTANTLY RELATED TO INSECTS AND ARE PESTS OF CEREAL CROPS INCLUDING MAIZE AND SORGHUM, ESPECIALLY UNDER CONDITIONS OF HIGH HEAT, ARIDITY, AND DROUGHT. IN FACT, DURING SUCH CONDITIONS, THE GENERALIST TWO-SPOTTED SPIDER MITE TETRANYCHUS URTICAE (WHICH FEEDS ON DIVERSE DICOT AND CEREAL CROP PLANTS) AND THE GRASS SPECIALIST BANKS GRASS MITE OLIGONYCHUS PRATENSIS (WHICH FEEDS MAINLY ON CEREALS SUCH AS MAIZE, SORGHUM AND WHEAT) CAN BECOME SIGNIFICANT PESTS OF CEREAL CROPS IN MANY AGRICULTURAL REGIONS. THIS PROJECT WILL INVESTIGATE THE GENOMIC, GENETIC, AND MOLECULAR BASES OF BOTH MITE SPECIES' ABILITY TO INTERACT WITH AND DAMAGE MAIZE, SORGHUM, AND BARLEY. WHILE BOTH THE TWO-SPOTTED SPIDER MITE AND THE BANKS GRASS MITE ARE MORPHOLOGICALLY SIMILAR AND FEED ON PLANTS IN A SIMILAR WAY, BECAUSE THEY DIFFER IN THE RANGE OF HOST PLANTS THEY FEED UPON, THEY MAY THEREFORE INTERACT DIFFERENTLY WITH THE CEREAL SPECIES ON WHICH THEY ARE CROP PESTS. HENCE, THE PROJECT WILL ASSESS SIMILARITIES AND DIFFERENCES IN THE TWO MITE SPECIES' MOLECULAR RESPONSES TO CEREAL HOSTS AND TEST THE ROLES OF SPECIFIC MITE GENES IN MEDIATING THE HERBIVORE-PLANT INTERACTIONS. TO ACCOMPLISH THE PROJECT OBJECTIVES THE GENOME OF THE BANKS GRASS MITE WILL BE SEQUENCED AND COMPARED TO THAT OF THE ALREADY EXISTING GENOME OF THE TWO-SPOTTED SPIDER MITE, AND THE TRANSCRIPTIONAL RESPONSES (WHICH GENES ARE TURNED ON OR OFF) OF BOTH MITE SPECIES TO MULTIPLE CEREAL PLANT HOSTS (MAIZE, SORGHUM, AND BARLEY) WILL ALSO BE ASSESSED. THE COMPARATIVE GENOMIC AND GENE EXPRESSION STUDIES WILL IDENTIFY SHARED GENES IN BOTH SPECIES THAT MAY BE IMPORTANT FOR MEDIATING THEIR ABILITY TO FEED ON CEREAL HOSTS, AS WELL AS GENES IN EACH SPECIES THAT MAY HAVE MORE SPECIES-SPECIFIC ROLES. FURTHER, SPECIFIC GENES IDENTIFIED AS CANDIDATES FOR ALLOWING SPIDER MITES TO COLONIZE, FEED UPON, AND DAMAGE CEREAL CROPS WILL BE FUNCTIONALLY TESTED USING CRISPR-CAS9 BASED GENE EDITING TECHNIQUES THAT HAVE RECENTLY BEEN DEVELOPED FOR SPIDER MITES. THE KNOWLEDGE AND GENETIC AND GENOMIC RESOURCES TO BE GENERATED BY THE PROJECT WILL INFORM GENOME-ENABLED APPROACHES TO CONTROL THESE TWO DESTRUCTIVE PESTS OF CEREAL CROPS FOR WHICH ECONOMICALLY IMPORTANT OUTBREAKS TYPICALLY OCCUR DURING CONDITIONS OF DROUGHT WHEN PLANTS ARE ALREADY EXPERIENCING A MAJOR STRESS THAT REDUCES CROP YIELDS. ADDITIONALLY, EDUCATIONAL MATERIALS TO BE DEVELOPED AND RELEASED VIA THE LEARN.GENETICS WEB RESOURCE WILL INFOR,M A DIVERSE AUDIENCE INCLUDING K-12 AND UNDERGRADUATE STUDENTS AND EDUCATORS, AND THE PUBLIC, ON THE IMPORTANCE OF HEAT AND DROUGHT STRESS ON CROPS IN THE CONTEXT OF HERBIVORES AND HERBIVORE-INDUCED IMPACTS ON CROP YIELDS. FINALLY, UNDERGRADUATE AND GRADUATE STUDENTS WILL BE TRAINED IN MOLECULAR, GENETIC, GENOMIC, AND BIOINFORMATIC METHODS OF IMPORTANCE FOR DEVELOPING MODERN AND SUSTAINABLE AGRICULTURAL PRACTICES.
$688,486University Of Utah · · FY2024 · National Institute of Food and Agriculture
Genome Editing of Human iPSCs to Study Inherited Hypertrophic Cardiomyopathy
$688,459Joseph C Wu · Stanford University · R01 · FY2019 · HL
Regulation of DNA methylation by TETs and QSER1
$688,423Todd R Evans · Weill Medical Coll Of Cornell Univ · R01 · FY2022 · HD
Mechanism and Inhibition of Thogotovirus Entry
$688,397Adrianus Cm Boon · Washington University · R01 · FY2024 · AI
Target Host Epigenetic Regulation of HIV Proviruses to Reinforce Viral Deep Latency in Microglia
$688,355Jian Zhu · Ohio State University · R01 · FY2024 · MH
Response and resistance to SHP2 inhibitors alone and in combination in Non-Small Cell Lung Cancer
$688,018Benjamin G. Neel · New York University School Of Medicine · R01 · FY2023 · CA
Response and resistance to SHP2 inhibitors alone and in combination in Non-Small Cell Lung Cancer
$688,018Benjamin G. Neel · New York University School Of Medicine · R01 · FY2022 · CA
Characterizing non-coding somatic and germline variant interactions in ovarian cancer
$688,012Simon Andrew Gayther · Cedars-Sinai Medical Center · R01 · FY2021 · CA
Modeling and Characterizing the Genomic Consequences of MED12 Mutations in Uterine Fibroids
$688,000Mazhar Adli · Northwestern University At Chicago · R01 · FY2025 · HD
Alzheimer Disease Genetic Architecture in African Americans
$687,987Lindsay A. Farrer · Boston University Medical Campus · R01 · FY2024 · AG
Alzheimer Disease Genetic Architecture in African Americans
$687,987Lindsay A. Farrer · Boston University Medical Campus · R01 · FY2023 · AG
Novel CRISPR-Cas9 protein delivery to T cells in vivo by targeting CD7
$687,900Guohua Yi · University Of Texas Hlth Ctr At Tyler · UG3 · FY2020 · AI
The role of TRIO signaling in neuronal development, synaptic function, and circuit connectivity
$687,884Anthony J Koleske · Yale University · R56 · FY2022 · MH
Project 2: Use of 2D cultures and 3D organoids to identify candidate antiviral compounds; to use genetic approaches to identify host genes that promote or protect against flavivirus infection
$687,797Lee Gehrke · Massachusetts Institute Of Technology · U19 · FY2017 · AI