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17,054 grants matching “genome editing”
Translating Dosage Compensation to Trisomy
$2,507,052Jeanne Bentley Lawrence · Univ Of Massachusetts Med Sch Worcester · RC4 · FY2010 · GM
Genomic and epigenomic mechanisms of pediatric ocular disorders
$2,505,807Robert Hufnagel · National Eye Institute · ZIA · FY2023 · EY
Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana)
$2,503,148Eugene Wei-Ming Yeo · University Of California, San Diego · U19 · FY2017 · MH
Genetic Approaches To Understanding Organ Development and Function
$2,503,076Lothar Hennighausen · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2018 · DK
Broad Institute Mendelian Genomic Research Center
$2,501,431Anne O'Donnell-Luria · Broad Institute, Inc. · U01 · FY2021 · HG
THE DOMESTIC PIG IS IMPORTANT BOTH FOR AGRICULTURE AND HUMAN BIOMEDICAL MODELING. THE PORCINE GENOME ASSEMBLY HAS BEEN SIGNIFICANTLY IMPROVED. HOWEVER, THE LACK OF FUNCTIONAL ANNOTATION PREVENTS FULL EXPLOITATION OF SINGLE NUCLEOTIDE VARIANT ANALYSIS FOR GENETIC IMPROVEMENT THROUGH TRADITIONAL BREEDING, AND LIMITS EFFICIENCY OF GENE EDITING OF SPECIFIC GENOME COMPONENTS TO UNDERSTAND FUNCTION AND ACCELERATE GENETIC IMPROVEMENT.THE FUNCTIONAL ANNOTATION OF ANIMAL GENOME (FAANG) CONSORTIUM IS DEDICATED TO DEVELOPING THIS FUNCTIONAL INFORMATION FOR THE GENOME OF DOMESTICATED ANIMAL SPECIES, INCLUDING THE PIG. THE LONG-TERM GOAL OF THIS PROJECT IS TO CREATE A RESOURCE FOR UNDERSTANDING THE EXPRESSION AND REGULATORY FUNCTION OF EACH SEGMENT OF THE PORCINE GENOME ACROSS AND WITHIN DIVERSE BIOLOGICAL STATES. THIS RESOURCE WILL IMPROVE GENOME-WIDE GENETIC VARIATION ANALYSES THROUGH FILTERING OF VARIANTS ASSOCIATED WITH IMPORTANT PHENOTYPES. IDENTIFYING SUCH GENOTYPE-PHENOTYPE RELATIONSHIPS WILL INCREASE OUR ABILITY TO PREDICT PHENOTYPE FROM GENOTYPE, A CRITICALLY IMPORTANT GOAL IN ANIMAL GENETIC IMPROVEMENT. FUNCTIONAL ANNOTATION WILL ALSO IMPROVE SELECTION OF GENOME POSITIONS FOR GENE EDITING FOR GENETIC IMPROVEMENT AND BIOMEDICAL MODELING. WE PROPOSE TO DRAMATICALLY INCREASE THE DEPTH AND BREADTH OF CURRENT DATA ON THE FUNCTION OF EACH REGION OF THE PORCINE GENOME. WE WILL ALSO GENERATE A COMMUNITY RESOURCE FOR SCIENTISTS IN BOTH THE PUBLIC AND PRIVATE SECTORS TO ACCESS THIS DATA. ACROSS ALL OBJECTIVES, WE WILL USE RNA ASSAYS TO DIRECTLY MEASURE DIFFERENT COMPONENTS OF GENE EXPRESSION INTO RNA AND THE STRUCTURE OF THE CHROMATIN USING A RANGE ASSAYS TO ANNOTATE A TREMENDOUS BREADTH OF BIOLOGICAL STATES. IN OBJECTIVE 1, WE WILL APPROXIMATELY TRIPLE THE NUMBER OF ADULT TISSUES CURRENTLY BEING ANNOTATED. IN OBJECTIVE 2, WE WILL ANNOTATE FOUR TISSUES AT IMPORTANT STAGES OF FETAL DEVELOPMENT, AND LINK ALLELE-SPECIFIC EXPRESSION WITH ALLELE-SPECIFIC CHROMATIN MODIFICATIONS THROUGH ANALYZING DIVERGENT-BREED RECIPROCAL CROSSES. IN OBJECTIVE 3, WE WILL ANNOTATE CIRCULATING WHITE BLOOD CELL POPULATIONS IN HEALTHY PIGS, AS WELL AS MACROPHAGE RESPONSES TO BACTERIAL AND VIRAL MIMICS. WE WILL ALSO PROFILE GENE EXPRESSION OF SINGLE CELLS IN COMPLEX CELL POPULATIONS FROM IMMUNE TISSUES TO MAXIMIZE ANNOTATION OF THESE CRITICAL TISSUES. IN OBJECTIVE 4, WE WILL USE ALL THESE DATA AS WELL AS PUBLIC FAANG DATA TO GENERATE A FIRST-GENERATION CHROMATIN STATE SEGMENTATION MAP.COMPLETION OF THESE OBJECTIVES WILL GREATLY EXPAND OUR FUNCTIONAL KNOWLEDGE OF THE PORCINE GENOME, AND CREATE AN IMPORTANT RESOURCE FOR AGRICULTURAL AND BIOMEDICAL RESEARCH.
$2,500,000Iowa State University Of Science And Technology · · FY2018 · National Institute of Food and Agriculture
Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease
$2,500,000Jonathan S. Weissman · Whitehead Institute For Biomedical Res · RM1 · FY2022 · HG
Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease
$2,500,000Jonathan S. Weissman · Whitehead Institute For Biomedical Res · RM1 · FY2023 · HG
Broad Institute Mendelian Genomic Research Center
$2,498,225Anne O'Donnell-Luria · Broad Institute, Inc. · U01 · FY2023 · HG
Transcription and Splicing Dynamics in Single Cells
$2,494,706Daniel Larson · Division Of Basic Sciences - Nci · ZIA · FY2022 · CA
Genomic Analyses for Elucidating Novel Targets for Symptoms Management
$2,490,364Hyung Suk Kim · National Institute Of Nursing Research · ZIA · FY2021 · NR
Mouse Genome Database (MGD): A Core Knowledge Resource for Functional Characterization of the Human Genome
$2,488,941Carol J Bult · Jackson Laboratory · U24 · FY2025 · HG
Mouse Genome Database (MGD): A Core Knowledge Resource for Functional Characterization of the Human Genome
$2,488,940Carol J Bult · Jackson Laboratory · U24 · FY2024 · HG
Molecular Analysis Of Leukocyte Activation By Chemoattractants
$2,486,098Philip Murphy · National Institute Of Allergy And Infectious Diseases · ZIA · FY2015 · AI
Solute And Water Transport In Renal Epithelia
$2,485,092Mark Knepper · National Heart, Lung, And Blood Institute · ZIA · FY2023 · HL
Molecular Biology of Mammalian Gametogenesis, Fertilization and Early Development
$2,481,590Jurrien Dean · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2025 · DK
Disease mechanism and therapies for retinal degeneration
$2,481,462Tiansen Li · National Eye Institute · ZIA · FY2024 · EY
Gene therapy for disorders of the extracellular matrix
$2,481,348Douglas Gould · University Of California, San Francisco · RF1 · FY2023 · NS
Role of Glucosylsphingosine in Parkinson Disease and Dementia with Lewy Bodies
$2,480,685Sreeganga S Chandra · Yale University · RF1 · FY2019 · NS
TCGA Molecular Analysis and Cancer Transcriptome Characterization
$2,479,250Larry Arthur · Leidos Biomedical Research, Inc. · N01 · FY2010 · CA
Starvation resistance and resilience of metabolic dysfunction in cavefish
$2,475,000Nicolas Rohner · Stowers Institute For Medical Research · DP2 · FY2020 · AG
Broad Institute Mendelian Genomic Research Center
$2,474,123Anne O'Donnell-Luria · Broad Institute, Inc. · U01 · FY2022 · HG
Center for Genomically Engineered Organs
$2,469,443George M Church · Harvard Medical School · RM1 · FY2015 · HG
Landscape of transcription in human and mouse
$2,469,258Thomas Raymond Gingeras · Cold Spring Harbor Laboratory · U54 · FY2015 · HG
ZFIN: The Zebrafish Model Organism Database
$2,464,000Monte Westerfield · University Of Oregon · U24 · FY2021 · HG