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38,696 grants matching “als”
Genotoxicity and mitochondrial toxicity of antiretroviral NRTI and PI drugs
$994,899Miriam C Poirier · Division Of Basic Sciences - Nci · ZIA · FY2009 · CA
Spatial Genomics for in situ single cell expression analysis in the brain
$994,538Kirsten Frieda · Spatial Genomics, Inc. · R44 · FY2020 · MH
Spatial Genomics for in situ single cell expression analysis in the brain
$994,538Kirsten Frieda · Spatial Genomics, Inc. · R44 · FY2021 · MH
Neurocognitive Aging: Epigenetic Dynamics, Plasticity and Network Contributions
$994,236Peter R Rapp · National Institute On Aging · ZIA · FY2015 · AG
Technology Development for 3D Electron Microscopy
$994,049Sriram Subramaniam · Division Of Basic Sciences - Nci · ZIA · FY2018 · CA
Optimization of an in vivo base editing strategy to treat SOD1-linked ALS
$993,968Thomas Gaj · University Of Illinois At Urbana-Champaign · U01 · FY2025 · NS
AQEarth: Program Empowering Communities to Explore Map and Improve Air Quality
$993,506John W Birks · Ludlum Measurements, Inc. · R44 · FY2022 · ES
Experimental Animal Models of TB: Chemotherapeutics and Imaging
$993,273Clifton Barry · National Institute Of Allergy And Infectious Diseases · ZIA · FY2025 · AI
Developing novel LOX inhibitors to target chemotherapy resistant TNBC
$992,932Ozgur Sahin · Loxigen, Inc. · R42 · FY2024 · CA
High-throughput development and characterization of compact tools for transcriptional and chromatin perturbations
$992,642Lacramioara Bintu · Stanford University · R01 · FY2022 · HG
High-throughput development and characterization of compact tools for transcriptional and chromatin perturbations
$992,590Lacramioara Bintu · Stanford University · R01 · FY2023 · HG
CIBER-2 IS A COLLABORATION BETWEEN RIT CALTECH AND UC IRVINE IN THE US AND KWANSEI GAKUIN UNIVERSITY (JAPAN) KASI (S. KOREA) AND ASIAA (TAIWAN). OUR SAME TEAM DEVELOPED THE PREVIOUS PAYLOAD CIBER-1 CARRIED OUT EXACTING CALIBRATION MEASUREMENTS FLEW IT 4 TIMES ANALYZED THE DATA AND PUBLISHED THE MAIN SCIENTIFIC FINDINGS. THE PI DR. ZEMCOV IS IN CHARGE OF OVERALL MANAGEMENT OF THE PROJECT SUPPORTED BY EXPERIENCED CO-IS BOCK AND MATSUURA WHO HAVE SUCCESSFULLY COLLABORATED ON 9 PREVIOUS SOUNDING ROCKET FLIGHTS. MAJOR HARDWARE COMPONENTS FOR CIBER-2 HAVE BEEN PROVIDED BY OUR INTERNATIONAL PARTNERS WITH NON-NASA FUNDING INCLUDING THE 28.5 CM TELESCOPE CAMERA OPTICS CRYOSTAT FLIGHT DATA SYSTEM H2RG DETECTOR ARRAYS GROUND-STATION AND LINEAR-VARIABLE FILTERS. WITH NASA FUNDING CALTECH RIT AND UC IRVINE HAVE DEVELOPED THE PAYLOAD STRUCTURE FOR THE CRYOGENIC INSTRUMENT FOCAL PLANE ASSEMBLIES CRYOGENIC SHUTTER A MOTORIZED CRYOGENIC POP-UP BAFFLE TUBE (TO REDUCE THERMAL EMISSION INTO THE OPTICS) A CRYOGENIC STAR TRACKER AND WARM READOUT ELECTRONICS. THE INSTRUMENT IS CURRENTLY 100% INTEGRATED AND HAS UNDERGONE A FIRST ROUND OF FLIGHT QUALIFICATION TESTS AT WALLOPS FLIGHT FACILITY. A VARIETY OF PROBLEMS WERE FOUND DURING THESE TESTS AND THE TEAM IS CURRENTLY MODIFYING THE HARDWARE AND IMPROVING THE EXPERIMENT S OVERALL PERFORMANCE RELIABILITY AND DATA QUALITY. AT RIT DR. PRIYADARSHINI BANGALE GSRA CHI NGUYEN AND A TEAM OF COLLABORATORS AND UNDERGRADUATES ARE CURRENTLY PERFORMING THESE UPGRADES AND TESTING THE EXPERIMENT. OUR TEAM IS CURRENTLY DEVELOPING THE SPECTRAL AND PHOTOMETRIC CALIBRATIONS REQUIRED FOR SCIENCE EXTRACTION AND PERFORMING TESTS AND VALIDATIONS ON THE CRYOGENIC STAR TRACKER. AN EXISTING LARGE VACUUM CHAMBER WILL BE USED TO TEST THE DEPLOYMENT OF THE POP-UP BAFFLE AT ITS CRYOGENIC OPERATING TEMPERATURE. LATER THIS YEAR WE WILL COMPLETE FINAL FLIGHT PREPARATIONS AND OPTICAL CALIBRATIONS BEFORE SHIPPING THE EXPERIMENT TO WALLOPS FLIGHT FACILITY TO BE RE-INTEGRATED AND TESTED WITH THE NASA- PROVIDED PAYLOAD SECTIONS IN PREPARATION FOR A SEQUENCE OF FLIGHTS. THIS 4-WEEK TEST CAMPAIGN WILL VALIDATE THE EXPERIMENT HARDWARE FOR FLIGHT AND VERIFY THE OPERATION OF THE CRYOGENIC STAR TRACKER WITH THE ATTITUDE CONTROL SYSTEM. THE ENTIRE PAYLOAD WILL PASS THE USUAL BATTERY OF ENVIRONMENTAL AND SEQUENCE TESTING TO REACH FLIGHT READINESS. AFTER THE INTEGRATION CAMPAIGN THE INSTRUMENT WILL BE SHIPPED TO WHITE SANDS MISSILE RANGE FOR FINAL ASSEMBLY AND OUR FIRST FLIGHT THAT IS CURRENTLY SCHEDULED FOR LATE FEBRUARY 2020. FOR THE FIRST FLIGHT WE PLAN TO OBSERVE FIELDS OVER A WIDE RANGE OF ECLIPTIC LATITUDES. THESE OBSERVATIONS WILL PROVIDE BOTH ABSOLUTE SPECTROPHOTOMETRY MEASUREMENTS AND SUFFICIENT ANISOTROPY DATA TO DETERMINE THE AMPLITUDE OF NEAR-IR FLUCTUATIONS FROM INFRARED TO OPTICAL WAVELENGTHS A SIGNIFICANT SCIENTIFIC ADVANCE. THIS PLAN PROVIDES THE BEST PROBABILITY OF OBTAINING PUBLISHABLE SCIENTIFIC RESULTS IN THE EVENT OF A TECHNICAL MISHAP IN THE FIRST FLIGHT (AS WAS THE CASE WITH CIBER-1 WHICH STILL PRODUCED THE TSUMURA ET AL. (2010) PAPER ON THE ZL SPECTRUM). A SECOND FLIGHT OCCURRING SOMETIME IN EARLY 2021 WILL BE DEVOTED TO ANISOTROPY MEASUREMENTS.
$992,531Rochester Institute Of Technology · · FY2020 · National Aeronautics and Space Administration
Services Research: Psychiatric Comorbidity in Drug Abuse
$992,458Robert K Brooner · Johns Hopkins University · R01 · FY2006 · DA
High-throughput development and characterization of compact tools for transcriptional and chromatin perturbations
$992,388Lacramioara Bintu · Stanford University · R01 · FY2021 · HG
An Inhaled Microbiome-Targeted Biotherapeutic for Treatment of COPD
$992,385Teodora Nicola · Alveolus Bio, Inc. · R44 · FY2025 · HL
Stem Cell Therapy and Growth Factor Therapy for ALS
$992,012Clive Niels Svendsen · Cedars-Sinai Medical Center · P01 · FY2010 · NS
Post-transcriptional regulation of energy usage: glucose and lipid metabolism
$991,859Myriam Gorospe · National Institute On Aging · ZIA · FY2017 · AG
Nmr Studies Of Biomolecular Structure, Function, And Dynamics
$991,553Robert E London · National Institute Of Environmental Health Sciences · ZIA · FY2018 · ES
Roles of RNA-binding Proteins in Programming Gene Expression in Mammals
$991,499Stefan Muljo · National Institute Of Allergy And Infectious Diseases · ZIA · FY2023 · AI
Functional & Structural Connectivity of Alcohol Use Disorders
$991,300Abdolreza Momenan · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2018 · AA
General Purpose Brain-Computer Interface (BCI) System
$991,297Jonathan Rickel Wolpaw · Wadsworth Center · R01 · FY2012 · EB
Neuroimaging of animal models of neurologic and psychiatric disorders
$991,173Yihong Yang · National Institute On Drug Abuse · ZIA · FY2019 · DA
Developing novel strategies for personalized treatment and prevention of ALS: Leveraging the global exposome, genome, epigenome, metabolome, and inflammasome with data science in a case/control cohort
$989,984Eva L Feldman · University Of Michigan At Ann Arbor · R01 · FY2021 · NS
An intervention to improve adolescent headache self-management
$989,919Kimberlee Jean Trudeau · Inflexxion, Inc. · R44 · FY2014 · HD
Mechanistic and translational studies of CBF leukemia
$989,695Paul Liu · National Human Genome Research Institute · ZIA · FY2014 · HG