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38,696 grants matching “als”
Metabolic basis of B cell lineage leukemia relapse
$1,036,898Markus Mãschen · Beckman Research Institute/City Of Hope · R35 · FY2017 · CA
Innovating Yeast and Human Genetics Approaches to Define Mechanisms of Neurodegenerative Disease
$1,036,834Aaron D. Gitler · Stanford University · R35 · FY2021 · NS
OXIDATIVE AND EXCITATORY TOXICITY IN NEURODEGENERATION
$1,036,445Massachusetts General Hospital · P01 · FY2002 · AG
A CORE FUNCTION OF THE AIST ANALYTIC CENTER FRAMEWORK IS TO FACILITATE RESEARCH AND ANALYSIS THAT USES THE FULL SPECTRUM OF DATA PRODUCTS AVAILABLE IN ARCHIVES HOSTING RELEVANT PUBLICLY AVAILABLE DATA. KEY TO THIS IS MAKING DATA FAIR (FINDABLE ACCESSIBLE INTEROPERABLE AND REUSABLE) NOT JUST FOR HUMANS BUT FOR AUTOMATED SYSTEMS. EFFECTIVE DATA DISCOVERY SERVICES AND FULLY AUTOMATED MACHINE-DRIVEN TRANSACTIONS REQUIRE METADATA THAT CAN BE UNDERSTOOD BY BOTH HUMANS AND MACHINES. BUT SUCH METADATA ARE UNCOMMON. MORE COMMONLY METADATA RECORDS ARE INADEQUATELY CONTEXTUALIZED INCOMPLETE OR SIMPLY DO NOT EXIST. WHEN THEY DO EXIST THEY OFTEN LACK THE SEMANTIC UNDERPINNINGS TO MAKE THEM MEANINGFUL. THE GOAL OF THE AUTOMATED METADATA PIPELINE (AMP) PROJECT IS TO (1) DEVELOP A FULLY-AUTOMATED METADATA PIPELINE THAT INTEGRATES MACHINE LEARNING AND ONTOLOGIES TO GENERATE SYNTACTICALLY AND SEMANTICALLY CONSISTENT METADATA RECORDS THAT ADVANCE FAIR OBJECTIVES AND SUPPORT EARTH SCIENCE RESEARCH FOR A DIVERSE GROUP OF STAKEHOLDERS RANGING FROM SCIENTISTS TO POLICY MAKERS AND (2) DEMONSTRATE THE APPLICATION OF AMP-ENHANCED DATA TO AUTOMATE AND SUBSTANTIALLY IMPROVE THE USE AND REUSE OF NASA-HOSTED DATA IN ENVIRONMENTAL/EARTH SYSTEMS MODELS IN THE ARTIFICIAL INTELLIGENCE FOR ECOSYSTEM SERVICES (ARIES VILLA ET AL. 2014) PLATFORM A DISTRIBUTED NETWORK OF ECOSYSTEM SERVICES AND EARTH SCIENCE MODELS AND DATA THAT RELIES ON SEMANTICS TO ASSEMBLE NETWORK-AVAILABLE DATA AND MODEL COMPONENTS INTO ECOSYSTEM SERVICES MODELS BUILT ON DEMAND AND OPTIMIZED FOR THE CONTEXT OF APPLICATION. ARIES IS A CONTEXT-AWARE MODELING SYSTEM THAT GIVEN ADEQUATE SEMANTICALLY-GROUNDED METADATA IS CAPABLE OF FINDING AND ASSESSING THE SUITABILITY OF CANDIDATE DATA SETS FOR USE WITH A PARTICULAR MODEL AND AUTOMATICALLY ESTABLISHING LINKAGES BETWEEN DATA SOURCES AND MODEL COMPONENTS PERFORMING A VARIETY OF MEDIATION AND PRE-PROCESSING TASKS TO INTEGRATE HETEROGENEOUS DATA SETS. THE AMP PROJECT AIMS TO USE MACHINE LEARNING TECHNIQUES TO AUTO-GENERATE SEMANTICALLY CONSISTENT VARIABLE-LEVEL METADATA RECORDS FOR NASA DATA PRODUCTS AND IN COLLABORATION WITH THE ARIES DEVELOPER AND USER COMMUNITIES DEMONSTRATE THEIR VALUE IN SUPPORTING SCIENTIFIC RESEARCH. IN SO DOING WE HOPE TO ACHIEVE SEVERAL OBJECTIVES: ADDRESS USABILITY AND SCALABILITY ISSUES FOR DATA PROVIDERS AND METADATA CURATORS IN CONNECTION WITH TOOLS FOR GENERATING ROBUST VARIABLE-LEVEL METADATA RECORDS IMPROVE THE SEMANTIC INTEROPERABILITY OF TARGET NASA DATA PRODUCTS BY LINKING CONCEPTS IN AMP-GENERATED METADATA RECORDS TO TERMS FROM WELL-ESTABLISHED EXTERNAL VOCABULARIES SUCH AS THE ENVIRONMENT ONTOLOGY (ENVO) THEREBY TAKING ADVANTAGE OF EXISTING TERM MAPPINGS BETWEEN ENVO AND ONTOLOGIES DEVELOPED BY OTHER COMMUNITIES OF PRACTICE INCLUDING NASA S SEMANTIC WEB FOR EARTH AND ENVIRONMENT TECHNOLOGY (SWEET) ONTOLOGY DEMONSTRATE THE BENEFITS OF SEMANTICALLY INTEROPERABLE FAIR DATA ACROSS COMMUNITIES OF PRACTICE. AMP WILL PROVIDE A PLATFORM FOR AUTO-GENERATING ROBUST FAIR-PROMOTING SEMANTICALLY CONSISTENT METADATA RECORDS USING NEURAL NETS TO ASSIGN VARIABLES TO ONTOLOGICAL CLASSES IN THE AMP ONTOLOGY. OUR APPROACH RECOGNIZES THAT THERE IS A WEALTH OF INFORMATION CONTAINED WITHIN THE DATA ITSELF WHICH CAN BE EXPLOITED TO GENERATE ACCURATE AND CONSISTENT METADATA. WE WILL WORK WITH THE GODDARD SPACE FLIGHT CENTER S (GSFC) EARTH SCIENCE (GES) DATA AND INFORMATION SERVICES CENTER (DISC) WHICH WILL PROVIDE ACCESS TO DATA VIA ITS OPENDAP SERVERS FOR TRAINING AND TESTING THE AMP PIPELINE AND FOR USE BY THE ARIES PLATFORM. AMP ADVANCES THE ANALYTIC CENTER FRAMEWORK OBJECTIVES OF ALLOWING SEAMLESS INTEGRATION OF NEW AND USER-SUPPLIED COMPONENTS AND DATA INCREASING RESEARCH CAPABILITIES AND SPEED HANDLING LARGE VOLUMES OF DATA EFFICIENTLY AND PROVIDING NOVEL DATA DISCOVERY TOOLS.
$1,036,352Lingua Logica Llc · · FY2020 · National Aeronautics and Space Administration
Genomic regulation of immune response in neurodegeneration in mice
$1,036,314Han-Yu Shih · National Eye Institute · ZIA · FY2021 · EY
Southeast Center for Agricultural Health and Injury Prevention
$1,036,294Robert H. McKnight · University Of Kentucky · U50 · FY2008 · OH
Metabolic basis of B cell lineage leukemia relapse
$1,035,561Markus Mãschen · Beckman Research Institute/City Of Hope · R35 · FY2018 · CA
Pediatric AIDS Clinical Trials Group
$1,035,290St. Jude Children'S Research Hospital · U01 · FY2005 · AI
Metabolic basis of B cell lineage leukemia relapse
$1,035,016Markus Mãschen · Beckman Research Institute/City Of Hope · R35 · FY2020 · CA
Developmental Funds
$1,034,770Charles W Roberts · St. Jude Children'S Research Hospital · P30 · FY2025 · CA
Spasticity and Upper Motor Neuron Disorders
$1,034,640Mary Kay Floeter · National Institute Of Neurological Disorders And Stroke · ZIA · FY2015 · NS
ClinSeq(c) - Molecular and Genetic Aspects
$1,034,538Leslie Biesecker · National Human Genome Research Institute · ZIA · FY2015 · HG
ClinSeq - Clinical and Behavioral Aspects
$1,034,538Leslie Biesecker · National Human Genome Research Institute · ZIA · FY2015 · HG
Molecular Studies of Malformations
$1,034,538Leslie Biesecker · National Human Genome Research Institute · ZIA · FY2015 · HG
Quantitative Biophotonics for Tissue Characterization and Function
$1,034,342Amir H Gandjbakhche · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2023 · HD
Functional and Structural Optical Brain Imaging
$1,034,342Amir H Gandjbakhche · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2023 · HD
CITY Health II Center for the Study of Community Health
$1,034,000Max Michael · University Of Alabama At Birmingham · U48 · FY2016 · DP
Preclinical testing of the splice modulating oligonucleotide LSP-GR1
$1,033,937Gordon J Lutz · Lifesplice Pharma, Llc · R44 · FY2015 · NS
Pediatric AIDS Clinical Trials Group
$1,033,769St. Jude Children'S Research Hospital · U01 · FY2004 · AI
Biomarkers of Catecholaminergic Neurodegeneration
$1,033,335David Goldstein · National Institute Of Neurological Disorders And Stroke · ZIA · FY2025 · NS
Area at Risk, Myocardial Infarction, and Myocardial Salvage
$1,033,278Andrew Arai · National Heart, Lung, And Blood Institute · ZIA · FY2014 · HL
Quantification of Myocardial Perfusion
$1,033,278Andrew Arai · National Heart, Lung, And Blood Institute · ZIA · FY2014 · HL
CITY Health II Center for the Study of Community Health
$1,033,000Max Michael · University Of Alabama At Birmingham · U48 · FY2015 · DP
STARRRS: an open rat resource for the study of reserve and resilience against Alzheimer's disease
$1,032,458Peter R Rapp · National Institute On Aging · ZIA · FY2021 · AG
Circuit function and visual signal processing in the retina
$1,031,995Jeffrey S Diamond · National Institute Of Neurological Disorders And Stroke · ZIA · FY2025 · NS