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17,828 grants matching “crispr”
Developmental Architecture of Structure and Color on Butterfly Wings
$722,020Brian A Counterman · Mississippi State University · · FY2018 · BIO
Implications and Vulnerabilities of APOBEC Mutagenesis in Breast Cancer
$721,982Sarat Chandarlapaty · Sloan-Kettering Inst Can Research · R01 · FY2020 · CA
Advancing the development of a novel class of small molecules for treating pan-coronavirus infections
$721,967Shirit Einav · Stanford University · R01 · FY2022 · AI
Mapping, modeling, and manipulating 3D contacts in vascular cells to connect risk variants to disease genes
$721,928Jesse M Engreitz · Stanford University · R01 · FY2022 · HL
c-Myc Function
$721,527David Levens · Division Of Basic Sciences - Nci · ZIA · FY2022 · CA
Computational Methods for Identifying Non-coding Cancer Drivers
$721,394Ekta Khurana · Weill Medical Coll Of Cornell Univ · R01 · FY2020 · CA
Improving risk allocation and developing novel therapies for children with T-ALL and T-LL
$721,069David T. Teachey · Children'S Hosp Of Philadelphia · R01 · FY2024 · CA
Engineering gene expression noise to modulate the collective inflammatory response
$720,840Kathryn Miller-Jensen · Yale University · · FY2023 · BIO
Chromatin Architecture Regulatory Mechanisms in Pathogenesis of B-Cell Lymphomas
$720,776Ari M. Melnick · New York University School Of Medicine · P01 · FY2025 · CA
Novel recombinant Rotavirus vaccine utilizing the probiotic microorganism Lactobacillus acidophilus
$720,054Gregg A Dean · Colorado State University · R01 · FY2024 · AI
Glaucoma Epigenetic Treatment with Light Activated CRISPR-dCas9
$719,989Le Qiu · Beth Israel Deaconess Medical Center · · FY2020 · ENG
A protein traffic control system that regulates left-right patterning and heart development
$719,910Rajat Rohatgi · Stanford University · R01 · FY2022 · HL
Biochemical and functional characterization of a novel anti-inflammatory biogenic amine
$719,898Laura Santambrogio · Weill Medical Coll Of Cornell Univ · R01 · FY2024 · AI
Biochemical and functional characterization of a novel anti-inflammatory biogenic amine
$719,898Laura Santambrogio · Weill Medical Coll Of Cornell Univ · R01 · FY2025 · AI
Basic Research on Hematopoietic Human Stem Cells
$719,889Harry L Malech · National Institute Of Allergy And Infectious Diseases · ZIA · FY2017 · AI
A Pathway for Necrotic Cell Death
$719,845David J Shapiro · University Of Illinois At Urbana-Champaign · R01 · FY2025 · CA
Probing cytosolic nucleic acid sensing pathways in cancer
$719,771Ashley Marie Laughney · Weill Medical Coll Of Cornell Univ · R01 · FY2025 · CA
Discovery and characterization of clinically actionable germline mutations in DNA damage repair (DDR) pathway genes in lung cancer
$719,691Semanti Mukherjee · Sloan-Kettering Inst Can Research · R37 · FY2022 · CA
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** WE PROPOSE TO ESTABLISH A FIVE-YEAR SUMMER RESEARCH EXPERIENCE FOR UNDERGRADUATES IN THE FIELD OF CROP GENOMICS AND AGRICULTURAL BIOTECHNOLOGY AT EAST CAROLINA UNIVERSITY (ECU). EACH YEAR, 10 UNDERGRADUATE STUDENTS WILL BE RECRUITED AND SELECTED INTO THIS PROGRAM TO PERFORM RESEARCH, WITH A FOCUS ON INVESTIGATING MICRORNA (MIRNA) FUNCTION IN FIVE DIFFERENT PLANT SPECIES TREATED WITH FIVE DIFFERENT ABIOTIC STRESSES, WHICH PERFECTLY FIT INTO THE GOALS OF THE AFRI ELI EDUCATION GRANT PROGRAM. AT LEAST HALF OF THE PARTICIPATING STUDENTS WILL BE UNDERREPRESENTED STUDENTS AND HALF WILL BE FROM OTHER ACADEMIC INSTITUTIONS, MAJORLY LOCAL COMMUNITY COLLEGES AND/OR HISTORICALLY BLACK COLLEGES OR UNIVERSITIES (HBCUS). EXPERTS AT ECU IN THE FIELD OF PLANT GENOMES AND AGRICULTURAL BIOTECHNOLOGY PROPOSE TO PROVIDE A RESEARCH PROGRAM OF INTERDISCIPLINARY ACADEMIC EDUCATION, MENTORING, AND RESEARCH-BASED EXPERIMENTAL LEARNING FOR PARTICIPATING UNDERGRADUATE STUDENTS.THIS PROPOSED PROGRAM WILL INTEGRATE TEACHING AND RESEARCH TOGETHER TO TRAIN OUR NEXT GENERATION FOR PROMOTING RESEARCH AND EXPERIMENTAL LEARNING FOR OUR UNDERGRADUATE STUDENTS SUCH THAT UPON GRADUATION THEY MAY ENTER THE AGRICULTURE WORKFORCE WITH EXCEPTIONAL SKILLS OR ENTER GRADUATE SCHOOL WITH AGRICULTURE-RELATED MAJORS, WHICH IS URGENTLY NEEDED IN THE EASTERN NORTH CAROLINA (NC), A MAJOR RURAL AREA IN NC. THIS PROJECT TARGETS THE USDA AFRI CHALLENGE AREA RESILIENT AGROECOSYSTEMS AND FOOD SECURITY; THIS PROJECT WILL ALSO ALIGN WITH USDA AFRI FOUNDATIONAL AREA PLANT HEALTH AND PRODUCTION AND PLANT PRODUCTS FOR PROVIDING FELLOWSHIPS FOR UNDERGRADUATE STUDENTS IN THIS FIELD. SPECIFICALLY, FOR EDUCATION, WE WILL DEVELOPA LECTURE AND ASSOCIATED LAB, CALLED CROP GENOMICS AND AGRICULTURAL BIOTECHNOLOGY FOR THIS PROGRAM, IN WHICH WE WILL TRAIN OUR UNDERGRADUATE STUDENTS ON BASIC FOUNDATIONAL KNOWLEDGE ON THE FIELD OF CROP GENOMICS AND AGRICULTURAL BIOTECHNOLOGY AS WELL AS CUTTING-EDGE HAND ON EXPERIMENTS AND TECHNOLOGY, INCLUDING THE ADVANCED DEEP SEQUENCING AND CRISPR GENE EDITING. ON THE SIDE OF RESEARCH, THE STUDENTS WILL INVESTIGATE THE IMPACT OF ENVIRONMENTAL STRESS ON CROP DEVELOPMENT AND MIRNA EXPRESSION PROFILES. SPECIFICALLY, WORLDWIDE THE AMOUNT OF ARABLE LAND HAS DECLINED IN RECENT DECADES AS A RESULT OF GLOBAL CLIMATE CHANGE. ARID CONDITIONS LEAD TO CROP PROBLEMS INCLUDING SALINITY AND DROUGHT STRESS, AND CONTINUE TO THREATEN LAND AVAILABILITY FOR AGRICULTURAL PURPOSES. USING MARGINAL SOILS LESS SUITABLE FOR CROP GROWTH IN MORE AGRICULTURAL PRACTICES HAS MADE THE DEVELOPMENT OF STRESS TOLERANT GERMPLASM AN IMPERATIVE TASK. HOWEVER, GERMPLASM DEVELOPMENT IS HAMPERED BY AN INCOMPLETE UNDERSTANDING OF THE BREADTH OF COPING STRATEGIES OF PLANTS WITH ABIOTIC STRESS. RECENTLY DISCOVERED MIRNAS ARE AN ESSENTIAL REGULATORY MOLECULE IN MANY BIOLOGICAL AND METABOLIC PROCESSES AND THE ROLE OF MIRNAS IN PLANT TOLERANCE TO ABIOTIC STRESS REQUIRES FURTHER RESEARCH. IN THIS FELLOWSHIP PROGRAM, STUDENTS WILL,WORK CLOSELY UNDER THE MENTORSHIP OF THE PD AND OUR MENTORS TO IDENTIFY MIRNAS RESPONSIVE TO ABIOTIC STRESS, AND TO INVESTIGATE THEIR REGULATORY MECHANISMS BY A COMBINATION OF ADVANCED, CUTTING-EDGE METHODOLOGIES. MORE IMPORTANTLY, THIS PROJECT WILL INVESTIGATE THE MIRNA REGULATORY MECHANISMS ACROSS DIFFERENT ABIOTIC STRESSES AMONG FIVE MAJOR PLANT SPECIES. THE ABILITY TO UNDERSTAND MIRNA REGULATORY NETWORKS DURING PLANT GROWTH UNDER STRESS CONDITION WILL EMPOWER FUTURE APPLIED RESEARCH IN CROP BREEDING USING NOVEL MIRNA-BASED BIOTECHNOLOGY BY USING TRANSGENIC AND CRISPR GENOME EDITING TECHNOLOGY.
$719,658East Carolina University · · FY2023 · National Institute of Food and Agriculture
Non-canonical epitope presentation and antigen processing by MHC-E
$719,468Klaus J Frueh · Oregon Health & Science University · R01 · FY2023 · AI
Rapid Detection of TB from Blood using Cell-Free DNA and CRISPR
$718,939Timothy Charles Rodwell · University Of California, San Diego · R01 · FY2025 · AI
Systematic Functional Interpretation of Regulatory Variants in Neuropsychiatric Disorders
$718,916Jubao Duan · Endeavor Health Clinical Operations · R01 · FY2025 · MH
A Comprehensive Human cDNA Library For Functional Gene Replacement in Drosophila
$718,693Hugo J Bellen · Baylor College Of Medicine · R24 · FY2016 · OD
Evaluating the Functional Impact of Genetic Diversity on Malaria Vaccine Candidates
$718,581Amy Kristine Bei · Yale University · R01 · FY2023 · AI
Chromatin Function During Transcription and DNA Repair at Single Molecule Resolutionin Living Cells
$718,506Taekjip Ha · Johns Hopkins University · U01 · FY2022 · DK