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15,273 grants matching “antimicrobial resistance”
A unique strategy for reshaping the antibiotics model: chemokine-inspired therapeutics for targeting the host and pathogen to counter infections caused by multidrug-resistant bacteria
$598,787Molly A Hughes · University Of Virginia · R01 · FY2020 · AI
Genetic Analysis of the Plant Defense Response
$598,746Frederick M Ausubel · Massachusetts General Hospital · R37 · FY2014 · GM
Genetic Analysis of Toxinogenesis in Vibrio Cholerae
$598,721John J Mekalanos · Harvard Medical School · R01 · FY2013 · AI
Novel Inhibitors to DHPS to Probe Catalytic Mechanism & Therapeutic Potential
$598,667Stephen W White · St. Jude Children'S Research Hospital · R01 · FY2008 · AI
Research Infrastructure Core
$598,599Song Gao · Texas Southern University · U54 · FY2020 · MD
Azithromycin to prevent post-discharge morbidity and mortality in Kenyan children
$598,584Judd L. Walson · University Of Washington · R01 · FY2016 · HD
Regulatory Role of Tandem Tryptophan Codons in Chlamydial Persistence
$598,267Reynaldo A Carabeo · University Of Nebraska Medical Center · R01 · FY2020 · AI
Southeastern Pennsylvania Adult and Pediatric Prevention Epicenter Network
$598,223Ebbing Lautenbach · University Of Pennsylvania · U54 · FY2024 · CK
Trial of Zinc Supplements for Young Infants with Clinical Severe Infection in Tanzania
$598,067Christopher Sudfeld · Harvard University D/B/A Harvard School Of Public Health · R01 · FY2025 · AI
Pharmacology of intrathecal/intraventricular polymyxins: A systems-based approach
$597,848Gauri G Rao · Univ Of North Carolina Chapel Hill · R01 · FY2019 · AI
Quorum sensing, diversity and skin inflammation
$597,745Alexander R Horswill · University Of Colorado Denver · R01 · FY2021 · AI
Mechanisms of Candida auris Colonization in the Skin
$597,630Shankar Thangamani · Purdue University · R01 · FY2025 · AI
Cross-Border Dynamics of MDR/XDR-TB Epidemiology by HIV Status in Tijuana, Mexico
$597,502Richard S Garfein · University Of California, San Diego · R56 · FY2009 · AI
Development of RSK Inhibitors as Novel Therapeutics for Yersinia pestis
$597,452Jeffrey Smith · Luna Innovations, Inc. · R44 · FY2008 · AI
Mechanisms of Chromosome Maintenance in Bacteria
$596,716Dhruba K Chattoraj · Division Of Basic Sciences - Nci · ZIA · FY2014 · CA
Small molecules as antibiotic potentiating agents against multi-drug resistant Gram-negative infections
$596,514Daina Zeng · Agile Sciences, Inc. · R44 · FY2016 · AI
US BRAZIL COLLABORATION ON IMMUNITY AND BIOMARKERS IN TUBERCULOSIS
$596,258Jerrold J. Ellner · Boston Medical Center · U01 · FY2011 · AI
Project 1: Co-stimulation and Regulation of Anti-viral Immunity
$596,255Arlene H Sharpe · Harvard Medical School · P01 · FY2019 · AI
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROJECT AIMS TO INVESTIGATE THE SOCIAL AND ENVIRONMENTAL SUSTAINABILITY OF INDUSTRIAL ANIMAL FARMING PRACTICES BY QUANTIFYING THE EXTERNALITIES THEY GENERATE THROUGH ENVIRONMENTAL PATHWAYS, AND THE RESULTING HARM TO RURAL COMMUNITIES AND THREAT TO PUBLIC HEALTH. OUR EMPIRICAL STRATEGY CAPTURES THE ENVIRONMENTAL CHANNELS OF EXPOSURE TO CONTAMINANTS FROM ANIMAL FARMING OPERATIONS USING FINE-RESOLUTION DATA WITH A LARGE SPATIOTEMPORAL COVERAGE TO ESTIMATE THEIR CAUSAL IMPACT ON: THE LOCAL ENVIRONMENT; THE HEALTH, QUALITY OF LIFE, AND VALUE OF ASSETS OF SURROUNDING COMMUNITIES; AND ANTIMICROBIAL RESISTANCE.OVER THE LAST CENTURY, U.S. LIVESTOCK PRODUCTION HAS UNDERGONE A STRUCTURAL TRANSFORMATION TOWARDS INCREASINGLY LARGE AND INTENSIVE CONFINED OPERATIONS, CALLED ANIMAL FEEDING OPERATIONS (AFOS). THE HIGH ANIMAL DENSITIES CONCENTRATED INSIDE THESE FARMS HAVE TWO IMPORTANT IMPLICATIONS: (1) THEY GENERATE, AT AN INDUSTRIAL SCALE, DUST AND ANIMAL WASTE THAT CONTAIN VARIOUS POLLUTANTS KNOWN TO BE DETRIMENTAL TO HUMAN HEALTH AND WELL-BEING; AND (2) THEY ARE SUSTAINED BY THE ROUTINE APPLICATION OF LARGE VOLUMES OF LOW-DOSE ANTIBIOTICS, FOSTERING THE SELECTION OF ANTIMICROBIAL RESISTANCE GENES IN THE LOCAL PATHOGEN POOL. THE POLLUTANTS GENERATED IN THE HIGH-DENSITY ENVIRONMENT (INCLUDING PARTICULATE MATTER, PATHOGENS AND MALODOR) AND THE BIOCHEMICAL PRODUCTS OF ANTIBIOTIC USE (ANTIBIOTIC RESISTANCE GENES AND DRUG RESIDUES) ARE THEN TRANSPORTED BY AIR AND WATER TO SURROUNDING COMMUNITIES.
$596,065University Of Chicago · · FY2022 · National Institute of Food and Agriculture
Resubmission: Elucidating Pediatric Sepsis by Defining Comprehensive Signatures for Diagnosis and Outcome
$595,488Prashant Mahajan · University Of Michigan At Ann Arbor · R01 · FY2022 · HD
Oral microbiome and inflammatory status in antimicrobially-treated oral cancer patients
$595,456Yvonne L Kapila · University Of California Los Angeles · R01 · FY2024 · CA
Mechanisms of Candida auris Colonization in the Skin
$595,450Shankar Thangamani · Purdue University · R01 · FY2023 · AI
Quorum sensing, diversity and skin inflammation
$595,187Alexander R Horswill · University Of Colorado Denver · R01 · FY2022 · AI
Drug resistance enablers and their role in antibiotic treatment failure
$595,177Vaughn Cooper · Broad Institute, Inc. · U19 · FY2022 · AI
Evaluating darobactins as antimicrobial agents
$595,176Kim Lewis · Northeastern University · R01 · FY2023 · AI