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17,054 grants matching “genome editing”
Genetic Factors in Birth Defects
$750,247James Mills · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2012 · HD
Scalable post-assembly editing software for finishing and annotating personal genomes
$750,001Timothy J Durfee · Dnastar, Inc. · R44 · FY2019 · GM
Scalable post-assembly editing software for finishing and annotating personal genomes
$750,001Timothy J Durfee · Dnastar, Inc. · R44 · FY2020 · GM
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SOYBEAN CYST NEMATODE (SCN) IS THE MOST YIELD LIMITING AND ECONOMICALLY IMPORTANT PATHOGEN OF SOYBEAN IN THE UNITED STATES WITH AVERAGE ANNUAL YIELD LOSSES ESTIMATED AT $1.5 BILLION. THE MOST EFFICIENT STRATEGY TO CONTROL SCN IS THE USE OF RESISTANT SOYBEAN CULTIVARS. HOWEVER, GIVEN THE NARROW GENETIC BASE OF SCN RESISTANCE IN COMMERCIAL SOYBEAN CULTIVARS GROWN IN THE UNITED STATES TOGETHER WITH THE HIGH GENETIC DIVERSITY OF FIELD POPULATIONS, SCN POPULATIONS HAVE EVOLVED TO OVERCOME RESISTANCE IN THESE CULTIVARS. THEREFORE, IDENTIFYING MAJOR SOYBEAN RESISTANCE GENES AGAINST THIS DEVASTATING PEST IS IMPERATIVE IN ORDER TO GENERATE DURABLE RESISTANCE AGAINST SCN AND PROTECT SOYBEAN YIELD AND INCREASE THE GROWTH AND ECONOMIC PERFORMANCE OF SOYBEAN FARMS AND THE AGROINDUSTRY SECTORS. WE RECENTLY IDENTIFIED A NOVEL RESISTANCE GENE CANDIDATE AND A HOST SUSCEPTIBLY GENE, WHICH SIGNIFICANTLY IMPACTED SOYBEAN RESPONSES TO ONE OF THE MOST WIDELY SPREAD SCN RACES. THE OVERALL GOAL OF THIS RESEARCH IS TO CONFIRM THE FUNCTION OF THESE TWO GENES IN CONFERRING A HIGH LEVEL OF RESISTANCE AGAINST SCN AND GENERATE NEW SCN-RESISTANT GERMPLASM FOR CULTIVAR DEVELOPMENT. FIRST, WE WILL USE TRANSGENIC AND GENOME EDITING APPROACHES TO INVESTIGATE THE IMPACT OF THE RESISTANCE GENE CANDIDATES ON SOYBEAN RESISTANCE TO VARIOUS RACES OF SCN AND DETERMINE ANY POTENTIAL FUNCTIONAL LINKAGE WITH THE KNOWN SCN RESISTANCE GENES. SECOND, WE WILL DETERMINE THE MECHANISM OF RESISTANCE USING AN INTEGRATIVE APPROACH OF MOLECULAR, BIOCHEMICAL, GENETIC AND GENOMIC TECHNIQUES. RESULTS FROM THIS RESEARCH PROJECT WILL BE TRANSLATED TO RESISTANT SOYBEAN GERMPLASM AND INTELLECTUAL PROPERTY THAT COULD BE POTENTIALLY USED BY THE PUBLIC AND PRIVATE SEED COMPANIES THROUGH TRADITIONAL BREEDING, OR NON GMO-GENOME EDITING APPROACHES TO GENERATE IMPROVED SOYBEAN CULTIVARS WITH BROAD-SPECTRUM AND DURABLE RESISTANCE AGAINST THE MOST DAMAGING PEST OF SOYBEAN PRODUCTION IN THE UNITED STATES.
$750,000University Of Tennessee · · FY2023 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SOYBEAN CYST NEMATODES (SCN) POSE A SUBSTANTIAL THREAT TO SOYBEAN PRODUCTION IN THE US, RESULTING IN ANNUAL YIELD LOSSES EXCEEDING $1.5 BILLION. THE PROLONGED RELIANCE ON THE PI88788 (RHG1) RESISTANCE SOURCE OVER THE PAST THREE DECADES HAS CAUSED RACE SHIFT IN SCN POPULATIONS, LEADING TO MORE VIRULENT RACES. THEREFORE, IT IS IMPERATIVE TO IDENTIFY AND DEVELOP ADDITIONAL SCN RESISTANCE SOURCES INDEPENDENT OF RHG1 AND RHG4 TO COMBAT THIS EVER-CHANGING PEST. THROUGH OUR PRIOR USDA-NIFA SUPPORTED RESEARCH, WE IDENTIFIED QSCN10 RESISTANT QTL THAT HARBORS GMBZIP10 GENE. REMARKABLY, SIGNIFICANT ALLELIC VARIATIONS IN GMBZIP10 STRONGLY CORRELATED WITH DIFFERENTIAL GENE EXPRESSION IN RESPONSE TO SCN INFECTION. NOTABLY, THE INCREASED EXPRESSION OF GMBZIP10 IN SOYBEAN COMPOSITE TRANSGENIC HAIRY ROOTS DEMONSTRATED ENHANCED SCN RESISTANCE COMPARED TO THE SUSCEPTIBLE ALLELE, OFFERING A PROMISING STRATEGY FOR ENGINEERING ROBUST AND BROAD-BASED SCN RESISTANCE THAT OPERATES INDEPENDENTLY OF RHG1/RHG4. HENCE, OUR INTEGRATED GENOMICS AND GENE-EDITING RESEARCH AIMS TO ENHANCE BROAD-BASED SCN RESISTANCE.THE OUTCOMES OF OUR RESEARCH HOLD THE PROMISE OF NOT ONLY ENHANCING OUR UNDERSTANDING OF THE MOLECULAR BASIS OF SCN RESISTANCE BUT ALSO PAVING THE WAY FOR UNCONVENTIONAL AND SUSTAINABLE STRATEGIES TO COMBAT THIS FORMIDABLE AND EVER-EVOLVING SOYBEAN PEST IN THE UNITED STATES.
$749,985University Of Missouri System · · FY2024 · National Institute of Food and Agriculture
Assessing Genomic, Regulatory and Transcriptional Variation at Single Nuclei Resolution in the Brains of Individuals with Autism Spectrum Disorder
$749,882Tomasz Nowakowski · University Of California, San Francisco · R01 · FY2022 · MH
Risk Alleles in Protein Quality Control Genes as Modifiers of Hypertrophic Cardiomyopathy
$749,824Sharlene M Day · University Of Pennsylvania · R01 · FY2024 · HL
Nucleome Positioning System for Spatiotemporal Genome Organization and Regulation
$749,775Yijun Ruan · Jackson Laboratory · U54 · FY2015 · DK
Development of a porcine model of polycystic kidney disease by multiplex gene-editing.
$749,640Daniel Fred Carlson · Recombinetics, Inc. · R44 · FY2017 · DK
Non-coding Variants Predisposing to Age-related Macular Degeneration
$749,531Bing Ren · Ludwig Institute For Cancer Res Ltd · R01 · FY2017 · HG
TRANSCRIPTOME AND EPIGENOME MAPPING IN DOPAMINE NEURONS FROM THE OPIOID EXPOSED HUMAN BRAIN
$749,470Schahram Akbarian · Icahn School Of Medicine At Mount Sinai · R01 · FY2019 · DA
The Jackson Laboratory Gene Editing Testing Center (JAX-GETC)
$749,269Stephen A Murray · Jackson Laboratory · U42 · FY2019 · OD
Establishing an Integrated Platform for Diploid Germplasm Conservation in Zebrafish (Danio rerio)
$749,214Jose B Cibelli · Michigan State University · R24 · FY2025 · OD
CAREER: Understanding the evolution and genetic basis of meiotic recombination rate
$749,180Sen Xu · University Of Texas At Arlington · · FY2021 · BIO
Guide RNA Binding Complex
$749,059Ruslan Aphasizhev · Boston University Medical Campus · R01 · FY2025 · AI
SZ-associated loci: Functional consequences and treatment opportunities
$749,021Dimitrios Avramopoulos · Johns Hopkins University · R01 · FY2019 · MH
Highly Specific ZFN-Based HSC Gene Editing Therapies Identified By In Vivo Barcode Nanoparticle Screens And Rationally Designed Mrna
$748,942James Dahlman · Georgia Institute Of Technology · UG3 · FY2020 · TR
Skin Biology and Diseases Resource-based Center at Mount Sinai
$748,822Elena Ezhkova · Icahn School Of Medicine At Mount Sinai · P30 · FY2025 · AR
Altered inflammatory response associated with acquired DNMT3A mutations
$748,808Minji Byun · Icahn School Of Medicine At Mount Sinai · R01 · FY2022 · HL
Joint genomic and statistical analyses of schizophrenia and bipolar to decipher genetic susceptibility
$748,802Roel A Ophoff · University Of California Los Angeles · R01 · FY2022 · MH
In vivo Perturb-map: scalable genetic screens with single-cell and spatial resolution in intact tissues
$748,598Xin Jin · Scripps Research Institute, The · R01 · FY2024 · HG
The impact of loss of function DNA sequence variants in the human protocadherin gene cluster on neural circuit assembly.
$748,572Thomas P Maniatis · Columbia University Health Sciences · R01 · FY2023 · MH
High-throughput methods for elucidating the control of chromatin accessibility
$748,525David K. Gifford · Massachusetts Institute Of Technology · R01 · FY2017 · HG
High-throughput methods for elucidating the control of chromatin accessibility
$748,525David K. Gifford · Massachusetts Institute Of Technology · R01 · FY2016 · HG
Deciphering the regulation of gene expression in the etiology of LOAD
$748,492Ornit Chiba-Falek · Duke University · R01 · FY2019 · AG