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24,576 grants matching “microbiome”
Optimism and Dementia-Related Health Outcomes
$1,047,616Laura D Kubzansky · Harvard University D/B/A Harvard School Of Public Health · R01 · FY2025 · AG
Determining the contribution of microbial-derived metabolites to protective immunity in obesity-driven cancer risk.
$1,046,868Liza Makowski Hayes · University Of Tennessee Health Sci Ctr · U01 · FY2025 · CA
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS APPLICATION IS RESPONDING TO PROGRAM AREA 3. FOOD SAFETY, NUTRITION, AND HEALTH, ADDRESSING 3C. DIET, NUTRITION AND THE PREVENTION OF CHRONIC DISEASES, A1344, BY INTEGRATING RESEARCH AND EDUCATION IN THE FOCUS AREAS 1) EVALUATION OF INNOVATIVE RESEARCH AND EDUCATIONAL STRATEGIES TO IMPROVE EATING PATTERNS THAT SUPPORT THE PREVENTION OF CHRONIC DISEASE AND 2) INVESTIGATE AND ASSESS NUTRITION RESEARCH WITH THE GOAL TO IMPROVE AND SUSTAIN HEALTH.POLYPHENOL-RICH DIETS HAVE BEEN ASSOCIATED WITH INCREASED RESILIENCE AGAINST OBESITY-ASSOCIATED CHRONIC DISEASES. STUDIES SHOW THAT INTESTINAL OBESITY-ASSOCIATED MICROBIAL DYSBIOSIS MAY NOT EFFECTIVELY METABOLIZE POLYPHENOLS, POSSIBLY RESULTING IN LIMITED BENEFITS. THIS PRESENTS A DISADVANTAGE TO THE VERY POPULATION THAT IS IN NEED OF THESE BENEFITS. OUR RECENT HUMAN CLINICAL STUDIES SHOWS THAT SYSTEMIC LEVELS OF TANNIN METABOLITES ARE SIGNIFICANTLY LOWER IN OBESE COMPARED TO LEAN INDIVIDUALS UPON CONSUMPTION, WHICH MAY LIMIT THEIR DERIVED HEALTH BENEFITS. THE OBJECTIVES AIM TO 1) EVALUATE THE INTERACTIONS BETWEEN MICROBIAL COMPOSITION, MACROMOLECULAR POLYPHENOLS, AND METABOLIC SIGNATURES IN ANAEROBIC FERMENTATIONS AND AN ANIMAL MODEL AND TO 2) EVALUATE MACROMOLECULAR POLYPHENOLSWITH ENZYMATIC AND PROBIOTIC STRATEGIES IN A RANDOMIZED, PLACEBO-CONTROLLED DOUBLE-BLINDED HUMAN CLINICAL TRIAL 3) PROVIDE HANDS-ON RESEARCH OPPORTUNITIES FOR UNDERREPRESENTED UNDERGRADUATE AND GRADUATE STUDENTS ENHANCED BY ASSET-BASED PRACTICES, 4) PROVIDE PROFESSIONAL DEVELOPMENT FOR 9TH-12TH GRADE SCIENCE, CAREER-TECHNOLOGY-EDUCATION (CTE) TEACHERS IN THE DEVELOPMENT OF HIGH-IMPACT LEARNING RESOURCES BASED ON THE HEALTH BENEFITS OF PLANT-BASED FOODS AND THE ROLE OF THE INTESTINAL MICROBIOME IN HEALTH AND DISEASE.THIS PROJECT WILL PROVIDE CRUCIAL INSIGHTS INTO POLYPHENOL-MICROBIOME INTERACTIONS AND SUSTAINABLE EDUCATIONAL OPPORTUNITIES FOR TEACHERS, UNDERGRADUATE AND GRADUATE STUDENTS.
$1,046,444Texas A&M Agrilife Research · · FY2023 · National Institute of Food and Agriculture
DISCOVERY OF SIGNALING SMALL MOLECULES (E.G. QUORUM SENSING MOLECULES) FROM THE MICROBIOME
$1,046,392Carnegie Mellon University · · FY2020 · Department of Energy
Airway metagenome & metabolome in bronchiolitis and risk of asthma: MARC-35 cohort
$1,044,092Kohei Hasegawa · Massachusetts General Hospital · R01 · FY2019 · AI
NEUTRALIZING BACTERIAL BIOWEAPONS IN THE HUMAN GUT THROUGH PRECISION MICROBIOME EDITING
$1,043,706University Of Wisconsin System · · FY2025 · Defense Threat Reduction Agency
UChicago Interdisciplinary Cancer Health Disparities SPORE
$1,043,400Olufunmilayo I Olopade · University Of Chicago · P20 · FY2019 · CA
Core A: Administrative, Career Development and Research Integration Core
$1,043,335Margaret Rita Karagas · Dartmouth College · P20 · FY2019 · GM
Vaccine and immunotherapy strategies for cancer and viruses causing cancer
$1,042,696Jay A Berzofsky · Division Of Clinical Sciences - Nci · ZIA · FY2021 · CA
Exploring roles of protein deamidation in oral inflammation
$1,042,335Pinghui Feng · University Of Southern California · R35 · FY2019 · DE
Integrative Single-Cell Atlas of Host and Microenvironment in Colorectal Neoplastic Transformation
$1,040,698Robert J Coffey · Vanderbilt University Medical Center · U2C · FY2023 · CA
Chemistry Core
$1,040,570Timothy S Bugni · University Of Wisconsin-Madison · U19 · FY2019 · AI
The Vaginal Microbiome: Disease, Genetics and the Environment
$1,040,524Gregory A Buck · Virginia Commonwealth University · UH2 · FY2009 · AI
Functional characterization of viral-bacterial-human interactions during antimicrobial and inflammatory perturbations across different lifespans
$1,040,503Gautam Dantas · Washington University · U01 · FY2025 · AT
A randomized, double-blind, multi-center comparative effectiveness study of spironolactone versus doxycycline hyclate for the treatment of acne in women
$1,040,468David J. Margolis · University Of Pennsylvania · U01 · FY2021 · AR
Clinical Research on Nonalcoholic Fatty Liver Disease
$1,040,313Joel Edward Lavine · Columbia University Health Sciences · U01 · FY2014 · DK
Cervical Cancer Prevention Prebiotic Device
$1,039,382Joanna Elizabeth Ellington · Glyciome, Llc · R44 · FY2025 · CA
Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
$1,039,095Adam Wayne Carrico · University Of Miami School Of Medicine · R01 · FY2022 · MH
Multidisciplinary Training Program in Lung Disease
$1,038,852Theodore J. Standiford · University Of Michigan At Ann Arbor · T32 · FY2020 · HL
Applying Bioinformatics to Research in Immune, Muscle, and Bone Diseases
$1,038,805Massimo Gadina · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIH · FY2017 · AR
The role of the intestinal microbiome in cancer immunotherapy
$1,038,040Marcel R M Van Den Brink · Beckman Research Institute/City Of Hope · R35 · FY2025 · CA
Genomics of Antibiotic Resistance in Bacterial Pathogens
$1,036,666Derrick Fouts · J. Craig Venter Institute, Inc. · U19 · FY2018 · AI
The 10,000 Families Cohort: a new study to understand the environmental causes of cancer
$1,036,207Jenny N. Poynter · University Of Minnesota · UG3 · FY2022 · CA
Chemistry Core
$1,035,799Timothy S Bugni · University Of Wisconsin-Madison · U19 · FY2023 · AI
Genetics and pathophysiology of systemic lupus erythematosus in global populations
$1,035,506Laura Lewandowski · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2022 · AR