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38,696 grants matching “als”
Initiation of DNA Replication in Mammalian Cells
$1,110,045Mirit Aladjem · Division Of Basic Sciences - Nci · ZIA · FY2010 · CA
THIS IS A CONTINUATION OF OUR PREVIOUS AND ONGOING EFFORTS TO ACCURATELY DETERMINE ABUNDANCES AND ISOTOPIC COMPOSITION OF NOBLE GASES IN SOLAR WIND DELIVERED BY GENESIS MISSION AND SPALLOGENIC NEON AND HELIUM IN SUB-MICRON COMETARY GRAINS IN THE OUTERMOST LAYER OF THE AEROGEL COLLECTOR FLOWN ON NASA'S STARDUST MISSION. OVER PREVIOUS YEARS WE DEVELOPED A CUSTOMIZED 8-MULTIPLIER MASS SPECTROMETER (IN COLLABORATION WITH NU INSTRUMENTS) AND REFINED A LASER TECHNIQUE FOR EXTRACTION OF SOLAR WIND NOBLE GASES FROM CM-SIZE GENESIS COLLECTORS WITH DEPTH PROFILING CAPABILITIES. THE MOST ABUNDANT ISOTOPES 36-38AR 82-86KR AND 129-136XE ARE NOW MEASURED WITH PERMIL PRECISION BUT THE PRECISION OF LOW-ABUNDANCE 78-80KR AND 124-128XE IS NOT YET SUFFICIENT TO SOLVE ISOTOPE COSMO-CHEMISTRY PROBLEMS. ONE OF THESE PROBLEMS IS THE ORIGIN OF THE ENIGMATIC PHASE-Q A MINOR FRACTION OF PRIMITIVE METEORITES CONTAINING MOST OF THE PLANETARY HEAVY NOBLE GASES. THE ISOTOPIC COMPOSITION OF XE IN PHASE-Q CAN BE APPROXIMATED BY LINEARLY FRACTIONATED SOLAR XE WITH THE ADDITION OF EITHER XE-HL (PRESUMABLY FROM PRESOLAR NANODIAMONDS) OR FROM 244PU FISSION MODIFIED BY ISOTOPE-SPECIFIC CHEMICAL FRACTIONATION. IN THE LATTER CASE THE ORIGIN OF PHASE Q IS SEEMINGLY LOCAL RATHER THAN PRESOLAR . WITH THE PRESENT PRECISION OF 124-128XE BOTH HYPOTHESIS HAVE STATISTICALLY INDISTINGUISHABLE LIKELIHOODS. BUT TRIPLE OR EVEN DOUBLE THE ANALYTICAL PRECISION FOR LIGHT SOLAR WIND XE ISOTOPES WILL ALLOW US TO DETERMINE WHICH ONE OF THE TWO HYPOTHESES IS LIKELY TO BE CORRECT. WE ALREADY HAVE BEEN ALLOCATED THE SOLAR WIND COLLECTORS REQUIRED TO IMPROVE XE COUNTING STATISTICS BY FACTOR OF 2. WE MADE ALL NECESSARY PREPARATIONS TO ESTIMATE BR ABUNDANCE IN THE SOLAR WIND USING THE 79BR(N GAMMA)80KR REACTION. ACCORDING OUR EXAMINATION OF VARIOUS NEUTRON IRRADIATED GENESIS SOLAR WIND COLLECTORS ONLY PURE UNCOATED SAPPHIRE (SAP) HAS AN ACCEPTABLE LEVEL OF TERRESTRIAL BR CONTAMINATION. WE ALREADY HAVE IN OUR POSSESSION ~ 5 SQ. CM OF SAP ACQUIRED RELIABLE BR STANDARDS AND DISCUSSED ALL DETAILS OF TIME-SPLIT NEUTRON IRRADIATION WITH THE MISSOURI RESEARCH REACTOR OUR NEIGHBOR AND LONG-TERM COLLABORATOR. THE MULTICOLLECTOR MASS-SPECTROMETER NOBLESSE WILL BE OPTIMIZED FOR MEASUREMENTS OF SMALL EXCESSES OF BR-DERIVED 80KR ON TOP OF SOLAR WIND KR IN NEUTRON-IRRADIATED SAP. THE FIRST IN THE US OUR NEW HELIX-MC+ MASS-SPECTROMETER IS THE ONLY INSTRUMENT IN OUR LAB CAPABLE OF RESOLVING DOUBLY CHARGED 40AR ++ FROM 20NE+. AFTER CERTAIN REQUIRED MODIFICATIONS AND ASSESSING THE REPRODUCIBILITY PRESSURE DEPENDENCE AND ACTUAL SYSTEMATICAL AND STATISTICAL ERRORS WE WILL USE OUR HELIX-MC+ FOR INDEPENDENT VERIFICATION OF (1) LIGHT SOLAR WIND NOBLE GASES TO RESOLVE THE EXISTING CONTROVERSY IN SW-NE COMPOSITION MEASURED IN ZURICH MINNESOTA AND OUR LAB; AND (2) OUR EARLIER FINDING OF SPALLATION 21NE IN TRACK-FREE AEROGEL FLOWN ON THE STARDUST MISSION. THE LATTER WILL BE COMPLIMENTED WITH THE STUDY OF MAJOR TARGET ELEMENTS (MG AL SI) IN TRACK-FREE AEROGEL AT ALS FACILITY AT LAWRENCE BERKELEY NATIONAL LABORATORY CARRIED OUT BY OUR COLLABORATORS RYAN OGLIORE AND ANDREW WESTPHALL. THE 21NE IRRADIATION RECORD MAY LEAD TO AN ESTIMATION OF THE COMET EROSION RATE BEFORE IT IS PERTURBED INTO THE INNER SOLAR SYSTEM. WE HAVE 10+ YEARS EXPERIENCE IN ANALYZING SOLAR WIND NOBLE GASES DELIVERED BY GENESIS DEDICATED MASS SPECTROMETERS AND CUSTOMIZED LASER EXTRACTION FACILITIES TO FULFILL THE GOALS OF THE PROPOSED STUDY WHICH IS IN LINE WITH THE GOAL OF THE LARS PROGRAM TO MAXIMIZE THE SCIENCE DERIVED FROM PLANETARY SAMPLE-RETURN MISSIONS THROUGH THE DEVELOPMENT OF LABORATORY INSTRUMENTATION AND/OR ADVANCED TECHNIQUES REQUIRED FOR THE ANALYSIS OF RETURNED SAMPLES AND DIRECT ANALYSIS OF SAMPLES ALREADY RETURNED TO EARTH .
$1,109,974Washington University, The · · FY2020 · National Aeronautics and Space Administration
Molecular Basis of Francisella tularensis-Macrophage Interactions
$1,109,832Jean Celli · National Institute Of Allergy And Infectious Diseases · ZIA · FY2011 · AI
UAB Alzheimer's Disease Research Center
$1,109,463Erik D Roberson · University Of Alabama At Birmingham · P20 · FY2020 · AG
Administration Core
$1,109,068Paul David Adams · University Of Calif-Lawrenc Berkeley Lab · P30 · FY2025 · GM
General Purpose Brain-Computer Interface (BCI) System
$1,108,996Jonathan Rickel Wolpaw · Wadsworth Center · R01 · FY2009 · EB
Study the pathogenesis of neurological disorders using human neural cultures derived from patient peripheral blood CD34 cells
$1,108,488Avindra Nath · National Institute Of Neurological Disorders And Stroke · ZIA · FY2019 · NS
TrkB.T1 as a Genetic Disease Modifier of Muscular Dystrophy
$1,108,102Susan G Dorsey · University Of Maryland Baltimore · RC2 · FY2009 · NR
Mechanisms of effective antibody neutralization of malaria parasites
$1,107,911Niraj Tolia · National Institute Of Allergy And Infectious Diseases · ZIA · FY2019 · AI
Mechanistic and translational studies of CBF leukemia
$1,106,669Paul Liu · National Human Genome Research Institute · ZIA · FY2021 · HG
Single-neuron population dynamics in human speech motor cortex for a speech prosthesis
$1,106,092Jaimie M Henderson · Stanford University · U01 · FY2024 · DC
Regulation Of Immunopathology In Bacterial And Parasitic Disease
$1,106,022Alan Sher · National Institute Of Allergy And Infectious Diseases · ZIA · FY2012 · AI
Metastasis of PTEN Mutant Prostate Cancer
$1,105,348Lloyd C Trotman · Cold Spring Harbor Laboratory · R01 · FY2025 · CA
The study of stem cell and neuro-vascular development
$1,105,165Yoh-Suke Mukouyama · National Heart, Lung, And Blood Institute · ZIA · FY2025 · HL
Biostatistics for Research in Environmental Health
$1,104,584Amy H Herring · Univ Of North Carolina Chapel Hill · T32 · FY2014 · ES
Viral And Cellular Factors Governing Efficient Gene Delivery
$1,103,474Maribeth V. Eiden · National Institute Of Mental Health · ZIA · FY2013 · MH
The Genetics Of Obsessive Compulsive Disorder
$1,103,180Dennis L Murphy · National Institute Of Mental Health · ZIA · FY2009 · MH
DEVELOPING A PERSONALIZED BLOOD BASED DIAGNOSTIC ASSAY FOR EARLY DETECTION OF ALS
$1,103,084Arizona State University · · FY2024 · Defense Health Agency
Pathobiology of Neurodegeneration in C9ORF72 Repeat Expansion
$1,102,845Leonard Petrucelli · Mayo Clinic Jacksonville · P01 · FY2016 · NS
Mitochondrial Integrated Stress Response in Neurological Diseases
$1,101,750Giovanni Manfredi · Weill Medical Coll Of Cornell Univ · R35 · FY2022 · NS
Mitochondrial Integrated Stress Response in Neurological Diseases
$1,101,750Giovanni Manfredi · Weill Medical Coll Of Cornell Univ · R35 · FY2025 · NS
Mitochondrial Integrated Stress Response in Neurological Diseases
$1,101,748Giovanni Manfredi · Weill Medical Coll Of Cornell Univ · R35 · FY2023 · NS
Immune Responses To Ocular Antigens
$1,101,586Igal Gery · National Eye Institute · ZIA · FY2013 · EY
Mechanisms of axon guidance during development
$1,101,478Edward Giniger · National Institute Of Neurological Disorders And Stroke · ZIA · FY2019 · NS
NICOTINIC CHOLINERGIC SYSTEMS IN MUTANT MICE
$1,101,065Baylor College Of Medicine · P01 · FY2002 · DA