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1,049,261 grants matching “t cell”
NEW YORK UNIVERSITY - NEW AWARD CONTROL NUMBER: 3405-1553 TEOSYNTE (DE-FOA-0003405) PROJECT TITLE: “TF REGULON ENGINEERING: REDUCING N2O EMISSIONS BY INCREASING NUE IN BIOENERGY CROPS” DESCRIPTION: “IN THIS ARPA-E PROPOSAL, WE WILL USE NOVEL MACHINE LEARNING (ML) APPROACHES TO IDENTIFY AND VERIFY GENES-OF-IMPORTANCE TO NUE AND ENHANCE THEIR FUNCTION IN PLANTS. SINCE MULTIPLE GENES AND PATHWAYS CONTRIBUTE TO NUE, WE FOCUS ON DISCOVERING THE REGULATORY NETWORKS THAT LINK TRANSCRIPTION FACTORS (TFS) TO THE EXPRESSION OF GENES THAT CONTROL NUE, TERMED TF-NUE REGULON. WE THEN ENGINEER MAIZE LINES TO HAVE EQUAL OR GREATER YIELD ON REDUCED N-FERTILIZER AND LOWER N2O EMISSIONS USING SYNTHETIC BIOLOGY PRINCIPLES TO MANIPULATE THESE NUE TF-REGULONS. TO ENABLE THIS NEW TECHNOLOGY, WE WILL CARRY OUT THREE TASKS ACROSS BIOENERGY CROPS TO FIND UNIVERSAL DESIGN TARGETS FOR TF-NUE REGULONS: IN TASK 1, OUR NOVEL ML ALGORITHM “BIPARTITE MACHINE LEARNING” WILL PREDICT TF PAIRS THAT COOPERATE TO IMPACT NUE TRAITS. IN TASK 2, WE WILL VERIFY THE FUNCTION OF INTERACTIVE TFS ON GENES AFFECTING NUE IN A HIGH-THROUGHPUT CELL-BASED SYSTEM TO PRIORITIZE INTERACTIVE TF-NUE REGULONS THAT MOST INFLUENCE FIELD NUE. IN TASK 3, WE WILL USE MODERN SYNTHETIC BIOLOGY TO MANIPULATE INTERACTIVE TF-REGULON SETS IN MAIZE TO INCREASE NUE AND REDUCE N2O IN FIELD TRIALS. THIS INNOVATIVE PIPELINE OF DISCOVERY WILL UNVEIL THE TF REGULONS THAT CONTROL THE AGRICULTURAL TRAIT OF NUE TO REDUCE N2O EMISSIONS AND DISRUPT AN AGRICULTURAL MARKET THAT DEPENDS ON ENVIRONMENTALLY COSTLY N-FERTILIZER.”
$4,818,837New York University · · FY2025 · Department of Energy
NHGRI/DIR Bioinformatics and Scientific Programming Core
$4,818,780Andreas Baxevanis · National Human Genome Research Institute · ZIC · FY2019 · HG
Conjugate nanoparticle platform development for HIV-1 envelope immunogens
$4,818,748Kevin O Saunders · Duke University · U19 · FY2023 · AI
HARC Center: HIV Accessory and Regulatory Complexes
$4,818,673Nevan J Krogan · University Of California, San Francisco · P50 · FY2019 · AI
Repair of localized DNA damage
$4,818,198Michael Seidman · National Institute On Aging · ZIA · FY2023 · AG
NOVEL THERAPEUTICS FOR PRION DISEASES
$4,815,605Stanley B Prusiner · University Of California, San Francisco · P01 · FY2006 · AG
Vasculo-neuronal pathophysiological interface in Alzheimerâs and Atherosclerosis
$4,815,513Luisa Iruela-Arispe · Northwestern University At Chicago · RF1 · FY2024 · NS
The Robert H. Lurie Comprehensive Cancer Center
$4,814,560Leonidas C Platanias · Northwestern University At Chicago · P30 · FY2015 · CA
CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM
$4,814,508Clark Algaier · Midwest Research Institute · N01 · FY2009 · ES
HARC Center: HIV Accessory and Regulatory Complexes
$4,812,427Nevan J Krogan · University Of California, San Francisco · P50 · FY2020 · AI
Infectious Diseases Research Technologies Core - RML
$4,812,299Robert Hohman · National Institute Of Allergy And Infectious Diseases · ZIC · FY2012 · AI
Harnessing Human DC Subsets for Improved Muscosal Vaccines
$4,812,281Jacques F Banchereau · Baylor Research Institute · U19 · FY2010 · AI
High-throughput targeted mutagenesis of mouse stem cell lines
$4,811,326Pieter J. De Jong · Children'S Hospital & Res Ctr At Oakland · U01 · FY2006 · HG
Familial Intracranial Aneurysm Study II (FIA II)
$4,810,953Joseph Paul Broderick · University Of Cincinnati · R01 · FY2010 · NS
Exploring novel nucleic acid therapeutic delivery methods and therapeutic strategies
$4,810,759Peter Sarnow · Stanford University · U19 · FY2022 · AI
Molecular Regulation of B cells and T cells in Human SLE
$4,808,545Ignacio E. Sanz · Emory University · U19 · FY2022 · AI
HARC Center: HIV Accessory and Regulatory Complexes
$4,808,425Nevan J Krogan · University Of California, San Francisco · P50 · FY2021 · AI
Long-read DNA sequencing of Alzheimers Disease and Related Dementias cases
$4,807,854Andrew Singleton · National Institute On Aging · ZIA · FY2020 · AG
CRISPR for Cure
$4,807,696Kamel Khalili · Temple Univ Of The Commonwealth · UM1 · FY2025 · AI
CRISPR for Cure
$4,807,696Kamel Khalili · Temple Univ Of The Commonwealth · UM1 · FY2021 · AI
CRISPR for Cure
$4,807,696Kamel Khalili · Temple Univ Of The Commonwealth · UM1 · FY2023 · AI
CRISPR for Cure
$4,807,696Kamel Khalili · Temple Univ Of The Commonwealth · UM1 · FY2024 · AI
CRISPR for Cure
$4,807,696Kamel Khalili · Temple Univ Of The Commonwealth · UM1 · FY2022 · AI
Center for Epigenomics of the Mouse Brain Atlas (CEMBA)
$4,805,483Joseph R Ecker · Salk Institute For Biological Studies · U19 · FY2018 · MH
Center for Epigenomics of the Mouse Brain Atlas (CEMBA)
$4,805,483Joseph R Ecker · Salk Institute For Biological Studies · U19 · FY2021 · MH