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15,273 grants matching “antimicrobial resistance”
Developing and Discovering Covalent Inhibitors through Fragmentation-First Experimentation
$2,503,299Daniel James Blair · St. Jude Children'S Research Hospital · R35 · FY2025 · GM
Task 11: Interventional Agent Development Services Program
$2,500,139Jon Mirsalis · Sri International · N01 · FY2017 · AI
Collaborative Research: FEC: Circular Waste Resource Recovery and Water Reuse Systems to Drive Sustainability and Resiliency of the Great Plains Rural Communities
$2,500,000Prathap Parameswaran · Kansas State University · · FY2025 · O/D
Active Vaccination and Passive Antibody Strategies to Prevent Disease Caused by Multidrug-Resistant Bacterial Pathogens
$2,500,000Myron Max Levine · University Of Maryland Baltimore · U19 · FY2022 · AI
Bioinformatics Tools and Services for Antimicrobial Resistance Research
$2,500,000Computercraft Corporation · N02 · FY2025 · LM
Active Vaccination and Passive Antibody Strategies to Prevent Disease Caused by Multidrug-Resistant Bacterial Pathogens
$2,500,000Myron Max Levine · University Of Maryland Baltimore · U19 · FY2019 · AI
Active Vaccination and Passive Antibody Strategies to Prevent Disease Caused by Multidrug-Resistant Bacterial Pathogens
$2,500,000Myron Max Levine · University Of Maryland Baltimore · U19 · FY2020 · AI
Active Vaccination and Passive Antibody Strategies to Prevent Disease Caused by Multidrug-Resistant Bacterial Pathogens
$2,500,000Myron Max Levine · University Of Maryland Baltimore · U19 · FY2023 · AI
Active Vaccination and Passive Antibody Strategies to Prevent Disease Caused by Multidrug-Resistant Bacterial Pathogens
$2,500,000Myron Max Levine · University Of Maryland Baltimore · U19 · FY2021 · AI
INFECTION AND DISEASE ADVERSELY IMPACT PERFORMANCE, GROWTH, MORBIDITY AND MORTALITY IN PRODUCTION ANIMALS AND HAS MAJOR ECONOMIC IMPACTS ON COMMERCIAL POULTRY PRODUCTION. THIS IS EXACERBATED BY CONSUMER WORRIES ABOUT ANTIBIOTIC USE, WHICH PRESSURES PRODUCERS TO USE ALTERNATIVE STRATEGIES TO PREVENT INFECTION. AN ILLUSTRATING EXAMPLE IS THE AVIAN INFLUENZA OUTBREAK OF 2015, WHICH HAS BEEN DESCRIBED AS THE WORST IN US HISTORY WITH THE LOSS OF OVER 48 MILLION BIRDS (CHICKEN AND TURKEY). THIS EVENT UNDERSCORES THE NEED TO FUNCTIONALLY ANNOTATING THE CHICKEN GENOME TO UNDERSTAND COMPLEX GENETIC TRAITS SUCH AS DISEASE RESISTANCE, WHICH IN TURN COULD SERVE AS A POWERFUL TOOL TO ENSURE SUSTAINABLE AGRICULTURAL SYSTEMS. FURTHERMORE, IN POULTRY PRODUCTION, ADDITIONAL FACTORS AFFECTING COMMERCIAL AND ECONOMIC PERFORMANCE NEED TO BE CONSIDERED IN BREEDING. FACTORS INCLUDING INTESTINAL HEALTH, EGG LAYING PERFORMANCE OR GROWTH EFFICIENCY IN BROILERS CERTAINLY ARE OF PARTICULAR ECONOMIC SIGNIFICANCE.TO IMPROVE OUR UNDERSTANDING OF THE UNDERLYING MECHANISMS CONTROLLING THESE AND OTHER TRAITS, IDENTIFICATION OF CIS-REGULATORY ELEMENTS ON THE GENOME IS WARRANTED. THESE REGULATORY ELEMENTS CONTROL THE EXPRESSION OF GENES AND CONSEQUENTLY PHENOTYPE; HOWEVER, THE TARGETED TISSUES AND CELLS FOR ANALYSIS NEED TO BE DETERMINED FOR EACH TRAIT OF INTEREST, AS THESE REGULATORY ELEMENTS ARE TISSUE SPECIFIC, AND EVEN DIFFER FROM CELL TO CELL WITHIN A GIVEN TISSUE. ADDITIONALLY, ENVIRONMENTAL FACTORS SUCH AS NUTRITION INTERACT WITH EPIGENETIC MODIFIERS WORKING AT THESE REGULATORY ELEMENTS, THUS MAKING IT POSSIBLE TO PROMOTE THE EXPRESSION OF DESIRABLE PRODUCTIVE TRAITS BY MANAGEMENT.IN THE PAST, SELECTIVE BREEDING OF POULTRY HAS RESULTED IN IMPROVED FEED CONVERSION RATIOS IN BROILERS, ALBEIT AT THE COST OF DECREASED IMMUNE COMPETENCE AND GREATER SUSCEPTIBILITY TO DISEASE. IN CONTRAST, SOME LINES OF BIRDS ARE KNOWN TO BE MORE RESISTANT TO A VARIETY OF PATHOGENS.THE EMERGENCE OF ANTIMICROBIAL RESISTANCE SUGGESTS THAT GENETIC RESISTANCE TO DISEASE WOULD PROVIDE AN ADVANTAGE OVER THE USE OF ANTIMICROBIALS. WHILE PARAMETERS OF IMMUNE COMPETENCE, SUCH AS ANTIBODY PRODUCTION, PHAGOCYTIC ACTIVITY AND CYTOKINE PRODUCTION OF THE HOST ARE KNOWN, THE GENETIC AND MOLECULAR BASIS FOR DISEASE RESISTANCE IS STILL NOT WELL UNDERSTOOD. IT HAS BECOME APPARENT THAT PATHOGENS INTERACT WITH EPIGENETIC REGULATORS OF THE HOST, AIDING IMMUNE EVASION AND REPLICATION OF THE PATHOGEN.IDENTIFICATION OF REGULATORY ELEMENTS AND THEIR INFLUENCE ON TARGET GENES DIRECTLY RESPONSIBLE FOR ENHANCED IMMUNITY IN POULTRY IS CRUCIAL IN ORDER TO SELECT FOR TRAITS THAT IMPROVE DISEASE RESISTANCE FOR BREEDING PURPOSES AND FLOCK HEALTH.
$2,499,551Western University Of Health Sciences · · FY2018 · National Institute of Food and Agriculture
Microbiome Discovery and Mechanisms to Combat Antibiotic Resistance at Mucosal Surfaces
$2,497,111Robert A Britton · Baylor College Of Medicine · U19 · FY2024 · AI
Discovery of natural product-based drugs from bacterial symbionts of insects
$2,479,629Cameron Robert Currie · University Of Wisconsin-Madison · RC4 · FY2010 · GM
Microbiome Discovery and Mechanisms to Combat Antibiotic Resistance at Mucosal Surfaces
$2,479,201Robert A Britton · Baylor College Of Medicine · U19 · FY2025 · AI
Targeting bacterial infections by imaging electrical interactions between host surface pathogens
$2,479,145Nikhil Malvankar · Yale University · DP2 · FY2017 · AI
Development of Therapeutic Candidates for Biodefense, Antimicrobial Resistant (AMR) Infections and Emerging Infectious Diseases
$2,475,623Nader Fotouhi · Global Alliance For Tb Drug Development · N01 · FY2024 · AI
Combatting antibiotic resistance with synthetic biology technologies
$2,472,375Ahmad Samir Khalil · Boston University (Charles River Campus) · DP2 · FY2016 · AI
GENE DUPLICATION AND AMPLIFICATION IN THE EVOLUTION OF ANTIMICROBIAL RESISTANCE: CLINICAL SIGNIFICANCE AND DIAGNOSTIC POTENTIAL
$2,471,598Massachusetts Institute Of Technology · · FY2015 · Defense Threat Reduction Agency
Attacking failure of antibiotic treatment by targeting antimicrobial resistance enabler cell-states
$2,470,464Tim Van Opijnen · Boston Children'S Hospital · U19 · FY2025 · AI
The Danger Model, and how tissues control Immunity
$2,469,012Polly C Matzinger · National Institute Of Allergy And Infectious Diseases · Z01 · FY2008 · AI
Dynamics of Colonization and Infection by Multidrug-resistant Pathogens in Immunocompromised and Critically Ill Patients (DYNAMITE)
$2,463,657Cesar Augusto Arias · University Of Texas Hlth Sci Ctr Houston · P01 · FY2020 · AI
Targeted Clincial Trials to Reduce the Risk of Antimocribal Resistance
$2,457,888Keith Kaye · Wayne State University · N01 · FY2016 · AI
Targeted Clincial Trials to Reduce the Risk of Antimocribal Resistance
$2,455,261Keith Kaye · Wayne State University · N01 · FY2013 · AI
Understanding the molecular mechanisms regulating fungal colonization and disease in the mammalian intestinal niche
$2,450,410Tobias M Hohl · Sloan-Kettering Inst Can Research · P01 · FY2025 · AI
Development of In Vitro Diagnostics for Biodefense, Antimicrobial Resistant Infections, and Emerging Infectious Diseases
$2,443,961Ramin Khaksar · Clear Labs, Inc. · N01 · FY2024 · AI
Vaccine Treatment and Evaluation Units: A Phase IV Trial to Evaluate Antimicrobial Therapy for Community Acquired Pneumonia in Children
$2,440,693Clarence Buddy Creech · · N01 · FY2017 · AI