← Leaderboards
Jonathan N Sachs
Yale University
$12,128,957
Attributed
$13,260,548
Total exposure
15
Grants
14
Lead (contact PI)
Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.
Funding over time
peak $2.1M · FY2005–25$2.5M$1.9M$1.3M$625K$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25
Funding mix
By agency
NIH$13,260,548 · 15
By mechanism
R01$7,048,870 · 4
R21$2,348,846 · 6
R35$1,967,619 · 1
R56$1,053,836 · 1
R61$734,778 · 1
F32$105,505 · 1
Top collaborators
- Benjamin Hackel4 shared
- Beau Richard Webber1 shared
Most similar at Yale University
Same institution · by research overlap
- Roel Gw Verhaak$8,014,607
- Lynn D Selemon$4,786,957
- John Hwa$13,604,925
- Kaya Bilguvar$1,745,772
- Angeliki Louvi$5,638,407
Others in their field
Top investigators on “Proteins”
- David Heimbrook · Leidos Biomedical Research, Inc.$354,061,551
- Randall J Bateman · Washington University$187,292,085
- Paul S. Aisen · Cognition Therapeutics, Inc.$175,382,342
- Reisa A. Sperling · Banner Health$145,046,481
- Barton F Haynes · Duke University$136,029,850
- Joseph L Goldstein · University Of Texas Sw Med Ctr/Dallas$102,433,280
Research focus
ProteinsStructureBaseBiophysicsInnovationSmall MoleculeFluorescenceSignal TransductionFluorescence Resonance Energy TransferMolecularPreventPathologyPublishingCellsNeuronsMembraneTumor Necrosis Factor ReceptorAlpha SynucleinBindingLigand BindingAlzheimer&AposPlayMalignant NeoplasmsComplex
Grant awards (44)
Human iPSC-Derived Chimeric Antigen Receptor Macrophages to Modulate Inflammation and Combat Tau-Induced Pathology$734,778
R61 · FY2025 · AG · contact PI
A novel approach to restore functional TDP43 for the treatment of FTD and ALS$404,058
R21 · FY2025 · AG · contact PI
Advanced multiplexing technologies with innovative Dual-Channel Dark-FRET biosensors for dynamic monitoring of alpha-synuclein pathophysiology: From cellular to in vivo models$184,136
R21 · FY2025 · AG · contact PI
Innovation in monitoring tau-induced dysregulation of the autophagy lysosomal pathway$426,250
R21 · FY2024 · AG · contact PI
Exploiting New Fibril Structures to Understand the Biophysical Basis for Oligomerization and Toxicity of Alpha-Synuclein$361,018
R01 · FY2024 · NS · contact PI
Advanced multiplexing technologies with innovative Dual-Channel Dark-FRET biosensors for dynamic monitoring of alpha-synuclein pathophysiology: From cellular to in vivo models$222,886
R21 · FY2024 · AG · contact PI
Exploiting New Fibril Structures to Understand the Biophysical Basis for Oligomerization and Toxicity of Alpha-Synuclein$379,855
R01 · FY2023 · NS · contact PI
Understanding the structural dynamics of TNF receptors$373,523
R35 · FY2023 · GM · contact PI
Elucidating the biophysics of pre-fibrillar, toxic tau oligomers: from amino acid motifs to neuronal dysfunction$529,406
R56 · FY2022 · AG · contact PI
Engineering synthetic ligands with potent allosteric inhibition of tumornecrosis factor receptors$443,728
R01 · FY2022 · EB
Exploiting new fibril structures to understand the biophysical basis for oligomerization and toxicity of alpha-Synuclein$386,249
R01 · FY2022 · NS · contact PI
Understanding the structural dynamics of TNF receptors$373,523
R35 · FY2022 · GM · contact PI
Elucidating the biophysics of pre-fibrillar, toxic tau oligomers: from amino acid motifs to neuronal dysfunction$524,430
R56 · FY2021 · AG · contact PI
Engineering synthetic ligands with potent allosteric inhibition of tumornecrosis factor receptors$434,853
R01 · FY2021 · EB
Exploiting new fibril structures to understand the biophysical basis for oligomerization and toxicity of alpha-Synuclein$391,364
R01 · FY2021 · NS · contact PI
How alpha-Synuclein misfolding promotes tau pathology in ADRD$377,307
R01 · FY2021 · NS · contact PI
Understanding the structural dynamics of TNF receptors$373,523
R35 · FY2021 · GM · contact PI
Exploiting new fibril structures to understand the biophysical basis for oligomerization and toxicity of alpha-Synuclein$412,147
R01 · FY2020 · NS · contact PI
Engineering synthetic ligands with potent allosteric inhibition of tumornecrosis factor receptors$380,139
R01 · FY2020 · EB
Understanding the structural dynamics of TNF receptors$373,523
R35 · FY2020 · GM · contact PI
Protein engineered inhibitors of TNF Receptor activation: new therapeutics and new technology$176,342
R21 · FY2020 · AI · contact PI
High-content image analysis to unravel TNF receptor oligomerization, kinetics and signaling$100,004
R35 · FY2020 · GM · contact PI
Understanding the structural dynamics of TNF receptors$373,523
R35 · FY2019 · GM · contact PI
Engineering synthetic ligands with potent allosteric inhibition of tumornecrosis factor receptors$269,685
R01 · FY2019 · EB
Protein engineered inhibitors of TNF Receptor activation: new therapeutics and new technology$214,842
R21 · FY2019 · AI · contact PI
Understanding and targeting the Methionine-Aromatic motif in oxidized alpha-Synuclein$176,433
R21 · FY2019 · NS · contact PI
Understanding and targeting the Methionine-Aromatic motif in oxidized alpha-Synuclein$214,933
R21 · FY2018 · NS · contact PI
Modeling synaptic vesicles: how does alpha-Synuclein inhibit fusion?$426,665
R01 · FY2017 · NS · contact PI
Dynamics of transmembrane dimers in TNF-Receptors by EPR and molecular simulation$331,814
R01 · FY2017 · GM · contact PI
Modeling synaptic vesicles: how does alpha-Synuclein inhibit fusion?$28,171
R01 · FY2017 · NS · contact PI
Modeling synaptic vesicles: how does alpha-Synuclein inhibit fusion?$354,611
R01 · FY2016 · NS · contact PI
Dynamics of transmembrane dimers in TNF-Receptors by EPR and molecular simulation$331,814
R01 · FY2016 · GM · contact PI
Modeling synaptic vesicles: how does alpha-Synuclein inhibit fusion?$368,223
R01 · FY2015 · NS · contact PI
Dynamics of transmembrane dimers in TNF-Receptors by EPR and molecular simulation$331,814
R01 · FY2015 · GM · contact PI
Modeling synaptic vesicles: how does alpha-Synuclein inhibit fusion?$13,612
R01 · FY2015 · NS · contact PI
Dynamics of transmembrane dimers in TNF-Receptors by EPR and molecular simulation$344,814
R01 · FY2014 · GM · contact PI
Modeling synaptic vesicles: how does alpha-Synuclein inhibit fusion?$332,315
R01 · FY2014 · NS · contact PI
Modeling synaptic vesicles: how does alpha-Synuclein inhibit fusion?$348,672
R01 · FY2013 · NS · contact PI
Sulfur-pi: a highly stabilizing binding motif in TNF receptors$177,057
R21 · FY2011 · CA · contact PI
THE EFFECT OF ?-SYNUCLEIN ON MEMBRANE STRUCTURE$1,094
P41 · FY2011 · RR · contact PI
Sulfur-pi: a highly stabilizing binding motif in TNF receptors$151,909
R21 · FY2010 · CA · contact PI
What controls the thickness of biological membranes$20,461
F32 · FY2006 · GM · contact PI
What controls the thickness of biological membranes$43,976
F32 · FY2005 · GM
What controls the thickness of biological membranes$41,068
F32 · FY2004 · GM