← Leaderboards
Hao Wu
Harvard Medical School
$47,906,316
Attributed
$53,297,702
Total exposure
29
Grants
22
Lead (contact PI)
Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.
Funding over time
peak $4.1M · FY2005–25$5M$3.8M$2.5M$1.3M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25
Funding mix
By agency
NIH$53,297,702 · 29
By mechanism
R01$42,554,446 · 16
R37$4,736,358 · 1
DP1$4,416,151 · 1
R21$489,500 · 1
P41$460,972 · 8
R56$433,385 · 1
Top collaborators
- Nathanael Schiander Gray5 shared
- Ari M. Melnick5 shared
- James J Chou3 shared
- Judy Lieberman3 shared
- Gerhard Wagner2 shared
- Kai W Wucherpfennig1 shared
Others in their field
Top investigators on “Structure”
- David Heimbrook · Leidos Biomedical Research, Inc.$475,333,582
- Barton F Haynes · Duke University$444,977,767
- Lawrence Corey · Fred Hutchinson Cancer Center$334,646,086
- Gary D Acton · University Of California-Davis$320,373,312
- Mitchell J Malone · Texas A&M Research Foundation$320,373,312
- Michael David Hughes · Harvard University D/B/A Harvard School Of Public Health$315,257,203
Research focus
StructureComplexSignal TransductionBiologicalMolecularBiochemicalProteinsHuman DiseaseCellsMediatingBaseN-TerminalPathway InteractionsC-TerminalReceptorSeriesMutationCell DeathCaspaseApoptosisIn VitroInflammatoryMemberPlay
Grant awards (120)
Elucidating structural and functional mechanisms of pyroptosis$889,996
R01 · FY2025 · AI · contact PI
Activating gasdermin pores to induce pyroptosis and stimulate anti-tumor immunity$733,069
R01 · FY2025 · CA · contact PI
Elucidating the functional mechanism of NLRP3 inflammasome activation$708,000
R01 · FY2025 · AI · contact PI
Armed nanobodies as anti-infectives and anti-tumor agents$542,900
R01 · FY2025 · AI · contact PI
NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing$531,000
R01 · FY2025 · AI · contact PI
Overcoming obstacles in structural elucidation of B cell antigen receptor assembly and lateral interaction$489,500
R21 · FY2025 · AI · contact PI
Elucidating structural and functional mechanisms of pyroptosis$849,927
R01 · FY2024 · AI · contact PI
CONTROL AND ACTIVATION OF THE TUMOR NECROSIS FACTOR RECEPTORS$767,592
R01 · FY2024 · AI
Activating gasdermin pores to induce pyroptosis and stimulate anti-tumor immunity$733,069
R01 · FY2024 · CA · contact PI
Elucidating the functional mechanism of NLRP3 inflammasome activation$708,000
R01 · FY2024 · AI · contact PI
Armed nanobodies as anti-infectives and anti-tumor agents$542,900
R01 · FY2024 · AI · contact PI
NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing$531,000
R01 · FY2024 · AI · contact PI
CONTROL AND ACTIVATION OF THE TUMOR NECROSIS FACTOR RECEPTORS$777,979
R01 · FY2023 · AI
Elucidating the functional mechanism of NLRP3 inflammasome activation$708,000
R01 · FY2023 · AI · contact PI
NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing$531,000
R01 · FY2023 · AI · contact PI
CONTROL AND ACTIVATION OF THE TUMOR NECROSIS FACTOR RECEPTORS$788,037
R01 · FY2022 · AI
NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing$531,000
R01 · FY2022 · AI · contact PI
Elucidating the structural mechanism of pore formation by the (GSDM) Gasdermin family$514,489
R01 · FY2022 · AI · contact PI
CONTROL AND ACTIVATION OF THE TUMOR NECROSIS FACTOR RECEPTORS$796,925
R01 · FY2021 · AI
Structural & Functional Studies of TLR/IL-1R Signaling$531,000
R37 · FY2021 · AI · contact PI
NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing$531,000
R01 · FY2021 · AI · contact PI
Elucidating the structural mechanism of pore formation by the (GSDM) Gasdermin family$514,489
R01 · FY2021 · AI · contact PI
CONTROL AND ACTIVATION OF THE TUMOR NECROSIS FACTOR RECEPTORS$821,630
R01 · FY2020 · AI
Molecular mechanisms of the RAG recombinase in V(D)J recombination and disease$634,401
R01 · FY2020 · AI · contact PI
Structural & Functional Studies of TLR/IL-1R Signaling$531,000
R37 · FY2020 · AI · contact PI
Elucidating the structural mechanism of pore formation by the (GSDM) Gasdermin family$514,489
R01 · FY2020 · AI · contact PI
Mechanistic Elucidation of Inflammasome Assembly and Regulation$442,500
R01 · FY2020 · AI · contact PI
Mechanistic elucidation of inflammasome assembly and regulation. Supplement: Testing drugs that curtail inflammasome activation to suppress SARS-CoV-2 pathogenesis$264,999
R01 · FY2020 · AI · contact PI
SMOCs: Novel Signal Transduction Complexes as New Targets for Drug Discovery$885,000
DP1 · FY2019 · HD · contact PI
Molecular mechanisms of the RAG recombinase in V(D)J recombination and disease$634,401
R01 · FY2019 · AI · contact PI
Structural & Functional Studies of TLR/IL-1R Signaling$531,000
R37 · FY2019 · AI · contact PI
Elucidating the structural mechanism of pore formation by the (GSDM) Gasdermin family$514,489
R01 · FY2019 · AI · contact PI
Mechanistic Elucidation of Inflammasome Assembly and Regulation$442,500
R01 · FY2019 · AI · contact PI
SMOCs: Novel Signal Transduction Complexes as New Targets for Drug Discovery$885,000
DP1 · FY2018 · HD · contact PI
Molecular mechanisms of the RAG recombinase in V(D)J recombination and disease$634,401
R01 · FY2018 · AI · contact PI
Structural & Functional Studies of TLR/IL-1R Signaling$531,000
R37 · FY2018 · AI · contact PI
Elucidating the structural mechanism of pore formation by the (GSDM) Gasdermin family$514,489
R01 · FY2018 · AI · contact PI
Mechanistic Elucidation of Inflammasome Assembly and Regulation$442,500
R01 · FY2018 · AI · contact PI
SMOCs: Novel Signal Transduction Complexes as New Targets for Drug Discovery$885,000
DP1 · FY2017 · HD · contact PI
MALT1 inhibitors for the treatment of chemo-resistant ABC-DLBCL$699,439
R01 · FY2017 · CA
Molecular mechanisms of the RAG recombinase in V(D)J recombination and disease$634,401
R01 · FY2017 · AI · contact PI
Structural & Functional Studies of TLR/IL-1R Signaling$531,000
R37 · FY2017 · AI · contact PI
Mechanistic Elucidation of Inflammasome Assembly and Regulation$442,500
R01 · FY2017 · AI · contact PI
SMOCs: Novel Signal Transduction Complexes as New Targets for Drug Discovery$876,150
DP1 · FY2016 · HD · contact PI
MALT1 inhibitors for the treatment of chemo-resistant ABC-DLBCL$700,976
R01 · FY2016 · CA
Molecular mechanisms of the RAG recombinase in V(D)J recombination and disease$653,651
R01 · FY2016 · AI · contact PI
Structural and functional elucidation of the necrosome in innate immune signaling$518,965
R01 · FY2016 · AI · contact PI
Mechanistic Elucidation of Inflammasome Assembly and Regulation$442,500
R01 · FY2016 · AI · contact PI
Structural & Functional Studies of TLR/IL-1R Signaling$435,000
R37 · FY2016 · AI · contact PI
SMOCs: Novel Signal Transduction Complexes as New Targets for Drug Discovery$885,001
DP1 · FY2015 · HD · contact PI
MALT1 inhibitors for the treatment of chemo-resistant ABC-DLBCL$708,042
R01 · FY2015 · CA
Structural and functional elucidation of the necrosome in innate immune signaling$518,965
R01 · FY2015 · AI · contact PI
Structural & Functional Studies of TLR/IL-1R Signaling$435,000
R37 · FY2015 · AI · contact PI
MALT1 inhibitors for the treatment of chemo-resistant ABC-DLBCL$684,151
R01 · FY2014 · CA
Structural and functional elucidation of the necrosome in innate immune signaling$518,965
R01 · FY2014 · AI · contact PI
Structural & Functional Studies of TLR/IL-1R Signaling$435,000
R37 · FY2014 · AI · contact PI
Molecular mechanisms of HLA-DM mediated peptide exchange$433,385
R56 · FY2014 · AI
Molecular elucidation of the CBM complex in NF-kappaB activation by antigen recep$387,585
R01 · FY2014 · AI · contact PI
MALT1 inhibitors for the treatment of chemo-resistant ABC-DLBCL$706,957
R01 · FY2013 · CA
Structural and functional elucidation of the necrosome in innate immune signaling$465,973
R01 · FY2013 · AI · contact PI
Structural & Functional Studies of TLR/IL-1R Signaling$408,900
R37 · FY2013 · AI · contact PI
Molecular elucidation of the CBM complex in NF-kappaB activation by antigen recep$364,330
R01 · FY2013 · AI · contact PI
Structural and functional studies of the IkappaB kinase (IKK) complex$360,688
R01 · FY2013 · AI · contact PI
Structural and functional elucidation of the necrosome in innate immune signaling$514,214
R01 · FY2012 · AI · contact PI
Structural and Functional Studies of the Caspase Activating Complex PIDDosome$383,710
R01 · FY2012 · AI · contact PI
Structural & Functional Studies of TLR/IL-1R Signaling$367,458
R37 · FY2012 · AI · contact PI
Structural and functional studies of the IkappaB kinase (IKK) complex$347,172
R01 · FY2012 · AI · contact PI
Molecular elucidation of the CBM complex in NF-kappaB activation by antigen recep$330,167
R01 · FY2012 · AI · contact PI
Structural & Functional Studies of TLR/IL-1R Signaling$65,601
R01 · FY2012 · AI · contact PI
Molecular elucidation of the CBM complex in NF-kappaB activation by antigen recep$55,769
R01 · FY2012 · AI · contact PI
Structural and functional studies of the IkappaB kinase (IKK) complex$35,488
R01 · FY2012 · AI · contact PI
Structural Studies of TNF Receptor Associated Factors (TRAFs)$399,790
R01 · FY2011 · AI · contact PI
Molecular elucidation of the CBM complex in NF-kappaB activation by antigen recep$376,448
R01 · FY2011 · AI · contact PI
Structural and Functional Studies of the Caspase Activating Complex PIDDosome$372,684
R01 · FY2011 · AI · contact PI
Structural and functional studies of the IkappaB kinase (IKK) complex$372,684
R01 · FY2011 · AI · contact PI
Structural and functional studies of DISC assembly and FLIP inhibition$355,377
R01 · FY2011 · AI · contact PI
STRUCTURAL/FUNCTIONAL STUDIES OF SIGNALING COMPLEXES IN APOPTOSIS & INFLAMMATION$27,437
P41 · FY2011 · RR · contact PI
Structural Studies of TNF Receptor Associated Factors (TRAFs)$403,985
R01 · FY2010 · AI · contact PI
Molecular elucidation of the CBM complex in NF-kappaB activation by antigen recep$380,250
R01 · FY2010 · AI · contact PI
Structural and Functional Studies of the Caspase Activating Complex PIDDosome$376,448
R01 · FY2010 · AI · contact PI
Structural and functional studies of the IkappaB kinase (IKK) complex$376,448
R01 · FY2010 · AI · contact PI
Structural and functional studies of DISC assembly and FLIP inhibition$359,279
R01 · FY2010 · AI · contact PI
STRUCTURAL/FUNCTIONAL STUDIES OF SIGNALING COMPLEXES IN APOPTOSIS & INFLAMMATION$17,425
P41 · FY2010 · RR · contact PI
Structural Studies of TNF Receptor Associated Factors (TRAFs)$499,990
R01 · FY2009 · AI · contact PI
Structural and Functional Studies of the Caspase Activating Complex PIDDosome$380,250
R01 · FY2009 · AI · contact PI
Structural and functional studies of the IkappaB kinase (IKK) complex$380,063
R01 · FY2009 · AI · contact PI
Structural and functional studies of DISC assembly and FLIP inhibition$363,212
R01 · FY2009 · AI · contact PI
Acquisition of automated crystallization and imaging systems$206,890
S10 · FY2009 · RR · contact PI
STRUCTURAL/FUNCTIONAL STUDIES OF SIGNALING COMPLEXES IN APOPTOSIS & INFLAMMATION$22,860
P41 · FY2009 · RR · contact PI
Structural Studies of TNF Receptor Associated Factors (TRAFs)$408,363
R01 · FY2008 · AI · contact PI
Structural and Functional Studies of the Caspase Activating Complex PIDDosome$378,000
R01 · FY2008 · AI · contact PI
Structural and functional studies of DISC assembly and FLIP inhibition$363,504
R01 · FY2008 · AI · contact PI
Structural Studies of TNF Receptor Associated Factors (TRAFs)$89,394
R01 · FY2008 · AI · contact PI
STRUCTURAL AND FUNCTIONAL STUDIES OF THE TNF SIGNALING MACHINERIES$42,358
P41 · FY2008 · RR · contact PI
Structural Studies of TNF Receptor Associated Factors (TRAFs)$416,416
R01 · FY2007 · AI · contact PI
Structural and functional studies of DISC assembly and FLIP inhibition$370,831
R01 · FY2007 · AI · contact PI
Structural Studies of Protein Caspase Inhibitors$331,034
R01 · FY2006 · AI · contact PI
Structural Studies of Nuclear Effectors of Apoptosis$281,378
R01 · FY2006 · GM · contact PI
STRUCTURAL AND FUNCTIONAL STUDIES OF THE TNF SIGNALING MACHINERIES$7,991
P41 · FY2006 · RR · contact PI
Structural Studies of Protein Caspase Inhibitors$339,000
R01 · FY2005 · AI
Structural Studies of Nuclear Effectors of Apoptosis$288,150
R01 · FY2005 · GM
STRUCTURAL STUDIES OF TNF SIGNALING AND APOPTOSIS$20,083
P41 · FY2005 · RR
TUMOR NECROSIS FACTOR RECEPTOR (TNFR) SIGNALING MACHINERY$10,218
P41 · FY2005 · RR
Structural Studies of Protein Caspase Inhibitors$339,000
R01 · FY2004 · AI
STRUCTURAL STUDIES OF DEATH RECEPTOR SIGNALING$296,625
R01 · FY2004 · AI
Structural Studies of Nuclear Effectors of Apoptosis$288,150
R01 · FY2004 · GM
Structural Studies of Protein Caspase Inhibitors$339,000
R01 · FY2003 · AI
STRUCTURAL STUDIES OF DEATH RECEPTOR SIGNALING$296,625
R01 · FY2003 · AI
STRUCTURAL STUDIES OF TNF RECEPTOR ASSOCIATED FACTORS$296,103
R01 · FY2003 · AI
Structural Studies of Nuclear Effectors of Apoptosis$288,150
R01 · FY2003 · GM
Structural Studies of Protein Caspase Inhibitors$364,000
R01 · FY2002 · AI
STRUCTURAL STUDIES OF DEATH RECEPTOR SIGNALING$296,625
R01 · FY2002 · AI
STRUCTURAL STUDIES OF TNF RECEPTOR ASSOCIATED FACTORS$287,480
R01 · FY2002 · AI
MACCHESS CONSORTIUM FOR PHASING METHODS IN MACROMOLECULAR CRYSTALLOGRAPHY$142,703
P41 · FY2002 · RR
STRUCTURAL STUDIES OF DEATH RECEPTOR SIGNALING$296,625
R01 · FY2001 · AI
STRUCTURAL STUDIES OF TNF RECEPTOR ASSOCIATED FACTORS$279,105
R01 · FY2001 · AI
MACCHESS CONSORTIUM FOR PHASING METHODS IN MACROMOLECULAR CRYSTALLOGRAPHY$142,703
P41 · FY2001 · RR
STRUCTURAL STUDIES OF DEATH RECEPTOR SIGNALING$321,625
R01 · FY2000 · AI
STRUCTURAL STUDIES OF TNF RECEPTOR ASSOCIATED FACTORS$270,975
R01 · FY2000 · AI
MACCHESS CONSORTIUM FOR PHASING METHODS IN MACROMOLECULAR CRYSTALLOGRAPHY$27,194
P41 · FY2000 · RR