← Leaderboards
Timothy A Springer
Boston Children'S Hospital
$59,155,872
Attributed
$59,155,872
Total exposure
34
Grants
32
Lead (contact PI)
Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants. They are the sole PI on all grants (the two match).
Funding over time
peak $6.8M · FY2005–25$10M$7.5M$5M$2.5M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25
Funding mix
By agency
NIH$91,188,409 · 36
By mechanism
P01$45,571,187 · 11
R01$35,299,227 · 12
R37$8,316,308 · 1
S10$952,390 · 1
R56$525,000 · 1
RC1$499,096 · 1
Top collaborators
No co-investigators on record.
Most similar at Boston Children'S Hospital
Same institution · by research overlap
- Michael William Lawlor$1,085,247
Others in their field
Top investigators on “Integrins”
- David A Cheresh · Scripps Research Institute$28,587,859
- Mark Howard Ginsberg · University Of California, San Diego$28,221,483
- Martin A. Schwartz · Yale University$23,274,443
- M. Amin Arnaout · Massachusetts General Hospital$23,064,887
- Edward Franklin Plow · Cleveland Clinic Foundation$22,902,830
- Jun Qin · Cleveland Clinic Foundation$22,797,066
Research focus
IntegrinsStructureMolecular ConformationAffinityLigandsComplexBaseMutationSiteCellsCell SurfaceLigand BindingMediatingMolecularBinding (Molecular Function)Signal TransductionGrantInsightProteinsBinding SitesSmall MoleculeBlood VesselsLeukocytesMeasurement
Grant awards (142)
Latent TGF-β2 Structure and Activation$706,464
R01 · FY2025 · HL · contact PI
Activation trajectories of integrin ñ5ò1$719,617
R01 · FY2024 · HL · contact PI
Latent TGF-β2 Structure and Activation$692,334
R01 · FY2024 · HL · contact PI
Activation trajectories of integrin ñ5ò1$734,302
R01 · FY2023 · HL · contact PI
Latent TGF-β2 Structure and Activation$706,464
R01 · FY2023 · HL · contact PI
Activation trajectories of integrin ñ5ò1$734,302
R01 · FY2022 · HL · contact PI
Latent TGF-β2 Structure and Activation$706,464
R01 · FY2022 · HL · contact PI
Structural basis of von Willebrand factor biology and physics$673,660
R01 · FY2022 · HL · contact PI
Activation trajectories of integrin ñ5ò1$734,302
R01 · FY2021 · HL · contact PI
Structural basis of von Willebrand factor biology and physics$673,660
R01 · FY2021 · HL · contact PI
Structural basis of von Willebrand factor biology and physics$673,660
R01 · FY2020 · HL · contact PI
Atypical Integrin alphaV beta8$442,500
R01 · FY2020 · HL · contact PI
Structural mechanisms underlying latency and activation of GDF8$394,594
R01 · FY2020 · CA · contact PI
Structural basis of von Willebrand factor biology and physics$673,660
R01 · FY2019 · HL · contact PI
Atypical Integrin alphaV beta8$442,500
R01 · FY2019 · HL · contact PI
Structures and Conformational Equilibria of Integrin alpha5 beta1$442,500
R01 · FY2019 · HL · contact PI
Structural mechanisms underlying latency and activation of GDF8$382,755
R01 · FY2019 · CA · contact PI
TGF-beta latency and activation$379,500
R01 · FY2019 · AR · contact PI
Lymphocyte Function Associated Antigens$581,719
R01 · FY2018 · CA · contact PI
Atypical Integrin alphaV beta8$442,500
R01 · FY2018 · HL · contact PI
Structures and Conformational Equilibria of Integrin alpha5 beta1$442,500
R01 · FY2018 · HL · contact PI
Structural mechanisms underlying latency and activation of GDF8$394,594
R01 · FY2018 · CA · contact PI
TGF-beta latency and activation$379,500
R01 · FY2018 · AR · contact PI
Lymphocyte Function Associated Antigens$581,719
R01 · FY2017 · CA · contact PI
Atypical Integrin alphaV beta8$442,500
R01 · FY2017 · HL · contact PI
Structures and Conformational Equilibria of Integrin alpha5 beta1$442,500
R01 · FY2017 · HL · contact PI
Leukocyte Adhesion Receptors Mac-1 and P150,95$435,000
R01 · FY2017 · AI · contact PI
Structural mechanisms underlying latency and activation of GDF8$394,594
R01 · FY2017 · CA · contact PI
TGF-beta latency and activation$379,500
R01 · FY2017 · AR · contact PI
Lymphocyte Function Associated Antigens$581,719
R01 · FY2016 · CA · contact PI
Structural Vaccinology of the Malaria Sporozoite Surface Sheath$455,381
R01 · FY2016 · AI · contact PI
Structures and Conformational Equilibria of Integrin alpha5 beta1$442,500
R01 · FY2016 · HL · contact PI
Leukocyte Adhesion Receptors Mac-1 and P150,95$435,000
R01 · FY2016 · AI · contact PI
Structural mechanisms underlying latency and activation of GDF8$413,844
R01 · FY2016 · CA · contact PI
TGF-beta latency and activation$379,500
R01 · FY2016 · AR · contact PI
MULTIDISCIPLINARY STRUCTURES AT VASCULAR CELL SURFACES$2,148,521
P01 · FY2015 · HL · contact PI
Lymphocyte Function Associated Antigens$587,572
R01 · FY2015 · CA · contact PI
Single molecule measurements on von Willebrand factor A1 and A2 domains$459,472
R01 · FY2015 · HL · contact PI
Structural Vaccinology of the Malaria Sporozoite Surface Sheath$455,381
R01 · FY2015 · AI · contact PI
Leukocyte Adhesion Receptors Mac-1 and P150,95$435,000
R01 · FY2015 · AI · contact PI
TGF-beta latency and activation$398,248
R01 · FY2015 · AR · contact PI
MULTIDISCIPLINARY STRUCTURES AT VASCULAR CELL SURFACES$2,137,616
P01 · FY2014 · HL · contact PI
Lymphocyte Function Associated Antigens$590,653
R01 · FY2014 · CA · contact PI
Integrin A Alpha IIB Beta 3 and Immune Thrombocytopenic Purpura$514,545
P01 · FY2014 · HL · contact PI
Structures of Alpha 4 Integrins, Ligands and Antagonists$501,217
P01 · FY2014 · HL · contact PI
Single molecule measurements on von Willebrand factor A1 and A2 domains$457,140
R01 · FY2014 · HL · contact PI
Structural Vaccinology of the Malaria Sporozoite Surface Sheath$455,381
R01 · FY2014 · AI · contact PI
Leukocyte Adhesion Receptors Mac-1 and P150,95$435,000
R01 · FY2014 · AI · contact PI
Integrin-targeted siRNA delivery for therapeutic gene silencing in blood cancers$390,943
R01 · FY2014 · CA · contact PI
Administration$75,016
P01 · FY2014 · HL · contact PI
MULTIDISCIPLINARY STRUCTURES AT VASCULAR CELL SURFACES$2,076,540
P01 · FY2013 · HL · contact PI
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$831,465
R37 · FY2013 · CA · contact PI
Single molecule measurements on von Willebrand factor A1 and A2 domains$444,079
R01 · FY2013 · HL · contact PI
Structural Vaccinology of the Malaria Sporozoite Surface Sheath$428,057
R01 · FY2013 · AI · contact PI
Leukocyte Adhesion Receptors Mac-1 and P150,95$408,900
R01 · FY2013 · AI · contact PI
Integrin A Alpha IIB Beta 3 and Immune Thrombocytopenic Purpura$379,627
P01 · FY2013 · HL · contact PI
Integrin-targeted siRNA delivery for therapeutic gene silencing in blood cancers$378,852
R01 · FY2013 · CA · contact PI
Structures of Alpha 4 Integrins, Ligands and Antagonists$371,869
P01 · FY2013 · HL · contact PI
Administration$123,751
P01 · FY2013 · HL · contact PI
MULTIDISCIPLINARY STRUCTURES AT VASCULAR CELL SURFACES$1,621,703
P01 · FY2012 · HL · contact PI
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$967,700
R37 · FY2012 · CA · contact PI
MULTIDISCIPLINARY STRUCTURES AT VASCULAR CELL SURFACES$657,957
P01 · FY2012 · HL · contact PI
Integrin A Alpha IIB Beta 3 and Immune Thrombocytopenic Purpura$609,907
P01 · FY2012 · HL · contact PI
Structures of Alpha 4 Integrins, Ligands and Antagonists$594,111
P01 · FY2012 · HL · contact PI
Integrin-targeted siRNA delivery for therapeutic gene silencing in blood cancers$439,110
R01 · FY2012 · CA · contact PI
Integrin A Alpha IIB Beta 3 and Immune Thrombocytopenic Purpura$394,119
P01 · FY2012 · HL · contact PI
Structures of Alpha 4 Integrins, Ligands and Antagonists$383,911
P01 · FY2012 · HL · contact PI
Single molecule measurements on von Willebrand factor A1 and A2 domains$335,038
R01 · FY2012 · HL · contact PI
Single molecule measurements on von Willebrand factor A1 and A2 domains$170,407
R01 · FY2012 · HL · contact PI
Structural Vaccinology of the Malaria Sporozoite Surface Sheath$146,652
R01 · FY2012 · AI · contact PI
Structural Vaccinology of the Malaria Sporozoite Surface Sheath$134,646
R01 · FY2012 · AI · contact PI
Administration$88,923
P01 · FY2012 · HL · contact PI
Administration$57,461
P01 · FY2012 · HL · contact PI
MULTIDISCIPLINARY STRUCTURES AT VASCULAR CELL SURFACES$2,462,957
P01 · FY2011 · HL · contact PI
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$971,178
R37 · FY2011 · CA · contact PI
Integrin A Alpha IIB Beta 3 and Immune Thrombocytopenic Purpura$609,907
P01 · FY2011 · HL · contact PI
Structures of Alpha 4 Integrins, Ligands and Antagonists$594,111
P01 · FY2011 · HL · contact PI
Leukocyte Adhesion Receptors Mac-1 and P150,95$588,111
R01 · FY2011 · AI · contact PI
Single molecule measurements on von Willebrand factor A1 and A2 domains$528,750
R01 · FY2011 · HL · contact PI
Structural Vaccinology of the Malaria Sporozoite Surface Sheath$525,000
R56 · FY2011 · AI · contact PI
Integrin-targeted siRNA delivery for therapeutic gene silencing in blood cancers$439,110
R01 · FY2011 · CA · contact PI
Administration$88,923
P01 · FY2011 · HL · contact PI
STRUCTURAL STUDIES OF HUMAN VWF DOMAINS$3,666
P41 · FY2011 · RR · contact PI
VISUALIZING THE PATHWAY OF INTEGRIN HEADPIECE OPENING INDUCED BY LIGAND BINDING$1,094
P41 · FY2011 · RR · contact PI
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$1,004,907
R37 · FY2010 · CA · contact PI
Leukocyte Adhesion Receptors Mac-1 and P150,95$611,852
R01 · FY2010 · AI · contact PI
Targeted siRNA delivery to aberrantly activated leukocytes for treating colitis$499,096
RC1 · FY2010 · DK · contact PI
STRUCTURAL STUDIES OF HUMAN VWF DOMAINS$13,960
P41 · FY2010 · RR · contact PI
INTEGRINS AND MODULAR SURFACE PROTEINS IN VASCULATURE$2,670,927
P01 · FY2009 · HL · contact PI
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$985,786
R37 · FY2009 · CA · contact PI
Leukocyte Adhesion Receptors Mac-1 and P150,95$618,032
R01 · FY2009 · AI · contact PI
Recognition of RGD-like Ligands by Integrins$557,128
P01 · FY2009 · HL · contact PI
Leukocyte Rolling Interactions in Vascular Shear Flow$468,905
P01 · FY2009 · HL · contact PI
STRUCTURAL STUDIES OF HUMAN VWF DOMAINS$2,166
P41 · FY2009 · RR · contact PI
RATIONALLY DESIGNED INTEGRIN B3 MUTANTS STABILIZED IN HIGH AFFINITY CONFORMATION$1,742
P41 · FY2009 · RR · contact PI
STRUCTURAL MODELING OF INTEGRIN \ALPHA_{IIB}\BETA_3 BY MOLECULAR DYNAMICS$790
P41 · FY2009 · RR · contact PI
INTEGRINS AND MODULAR SURFACE PROTEINS IN VASCULATURE$2,549,658
P01 · FY2008 · HL · contact PI
Pulsed EPR Spectrometer$952,390
S10 · FY2008 · RR · contact PI
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$724,983
R37 · FY2008 · CA · contact PI
Leukocyte Adhesion Receptors Mac-1 and P150,95$557,406
R01 · FY2008 · AI · contact PI
Recognition of RGD-like Ligands by Integrins$533,029
P01 · FY2008 · HL · contact PI
Leukocyte Rolling Interactions in Vascular Shear Flow$449,062
P01 · FY2008 · HL · contact PI
STRUCTURAL MODELING OF INTEGRIN \ALPHA_{IIB}\BETA_3 BY MOLECULAR DYNAMICS$473
P41 · FY2008 · RR · contact PI
INTEGRINS AND MODULAR SURFACE PROTEINS IN VASCULATURE$2,534,463
P01 · FY2007 · HL · contact PI
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$720,190
R37 · FY2007 · CA · contact PI
Recognition of RGD-like Ligands by Integrins$669,845
P01 · FY2007 · HL · contact PI
Leukocyte Adhesion Receptors Mac-1 and P150,95$568,200
R01 · FY2007 · AI · contact PI
Leukocyte Rolling Interactions in Vascular Shear Flow$564,892
P01 · FY2007 · HL · contact PI
3-D STRUCTURE PREDICTION OF TMD DOMAIN OF INTEGRIN$298
P41 · FY2007 · RR · contact PI
INTEGRINS AND MODULAR SURFACE PROTEINS IN VASCULATURE$2,542,576
P01 · FY2006 · HL · contact PI
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$722,556
R37 · FY2006 · CA · contact PI
Recognition of RGD-like Ligands by Integrins$662,496
P01 · FY2006 · HL · contact PI
Leukocyte Rolling Interactions in Vascular Shear Flow$559,272
P01 · FY2006 · HL · contact PI
3-D STRUCTURE PREDICTION OF TMD DOMAIN OF INTEGRIN$1,012
P41 · FY2006 · RR · contact PI
INTEGRINS AND MODULAR SURFACE PROTEINS IN VASCULATURE$2,526,971
P01 · FY2005 · HL
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$720,910
R37 · FY2005 · CA
Recognition of RGD-like Ligands by Integrins$659,207
P01 · FY2005 · HL
LEUKOCYTE ADHESION RECEPTORS MAC 1 AND P150,95$563,472
R01 · FY2005 · CA
Leukocyte Rolling Interactions in Vascular Shear Flow$543,512
P01 · FY2005 · HL
INTEGRINS AND MODULAR SURFACE PROTEINS IN VASCULATURE$1,709,098
P01 · FY2004 · HL
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$666,633
R37 · FY2004 · CA
LEUKOCYTE ADHESION RECEPTORS MAC 1 AND P150,95$547,060
R01 · FY2004 · CA
INTEGRINS AND MODULAR SURFACE PROTEINS IN VASCULATURE$1,660,699
P01 · FY2003 · HL
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$565,521
R01 · FY2003 · CA
LEUKOCYTE ADHESION RECEPTORS MAC 1 AND P150,95$531,126
R01 · FY2003 · CA
STRUCTURE OF INTEGRINS AND YWTD BETA PROPELLER DOMAINS$310,488
P01 · FY2003 · HL
RECOGNITION OF RGD-LIKE LIGANDS BY INTEGRINS$310,488
P01 · FY2003 · HL
INTEGRINS AND MODULAR SURFACE PROTEINS IN VASCULATURE$1,613,245
P01 · FY2002 · HL
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$550,993
R01 · FY2002 · CA
LEUKOCYTE ADHESION RECEPTORS MAC 1 AND P150,95$515,657
R01 · FY2002 · CA
STRUCTURE OF INTEGRINS AND YWTD BETA PROPELLER DOMAINS$310,488
P01 · FY2002 · HL
LEUKOCYTE ROLLING INTERACTIONS IN VASCULAR SHEER FLOW$310,488
P01 · FY2002 · HL
INTEGRINS AND MODULAR SURFACE PROTEINS IN VASCULATURE$1,567,168
P01 · FY2001 · HL
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$536,888
R01 · FY2001 · CA
LEUKOCYTE ADHESION RECEPTORS MAC 1 AND P150,95$500,636
R01 · FY2001 · CA
LEUKOCYTE ROLLING INTERACTIONS IN VASCULAR SHEER FLOW$310,488
P01 · FY2001 · HL
STRUCTURE OF INTEGRINS AND YWTD BETA PROPELLER DOMAINS$310,488
P01 · FY2001 · HL
INTEGRINS AND MODULAR SURFACE PROTEINS IN VASCULATURE$1,552,438
P01 · FY2000 · HL
LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS$523,193
R01 · FY2000 · CA
LEUKOCYTE ADHESION RECEPTORS MAC-1 AND P150,95$464,881
R01 · FY2000 · CA
STRUCTURE OF INTEGRINS AND YWTD BETA PROPELLER DOMAINS$310,488
P01 · FY2000 · HL
LEUKOCYTE ROLLING INTERACTIONS IN VASCULAR SHEER FLOW$310,488
P01 · FY2000 · HL