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David A. Sinclair
Harvard University (Medical School)
$25,944,681
Attributed
$25,944,681
Total exposure
12
Grants
12
Lead (contact PI)
Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants. They are the sole PI on all grants (the two match).
Funding over time
peak $3.2M · FY2005–25$5M$3.8M$2.5M$1.3M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25
Funding mix
By agency
NIH$25,944,681 · 12
By mechanism
R01$13,199,993 · 6
DP1$5,932,500 · 1
R37$4,128,877 · 1
P01$1,540,859 · 1
R21$1,092,452 · 2
R13$50,000 · 1
Top collaborators
No co-investigators on record.
Most similar at Harvard University (Medical School)
Same institution · by research overlap
- Kevin Struhl$33,571,953
- Beate Lanske$6,880,495
- Pinghui Feng$20,425,150
- Aimee M Dudley$8,642,583
- Zachary David Aron$7,720,492
Others in their field
Top investigators on “Tissues”
- David Heimbrook · Leidos Biomedical Research, Inc.$346,311,904
- Lawrence Corey · Fred Hutchinson Cancer Center$230,011,824
- Larry Arthur$159,140,370
- Douglas S. Hawkins · Children'S Hosp Of Philadelphia$157,315,120
- Judith S. Currier · University Of California Los Angeles$138,805,403
- Joseph J. Eron · Univ Of North Carolina Chapel Hill$138,805,403
Research focus
TissuesCellsAgingLongevityBiologyMammalsResponseGenesAge RelatedIn VivoMediatingMitochondriaGenomeBaseMolecularPreventOrganismGeneticProteinsSirtuinsYeastsPhysiologicalNuclearTechnology
Grant awards (63)
Using cellular co-biosis and age programmable mice to derive a global interaction map of aging hallmarks$436,002
R01 · FY2025 · AG · contact PI
Using cellular co-biosis and age programmable mice to derive a global interaction map of aging hallmarks$453,583
R01 · FY2024 · AG · contact PI
Using cellular co-biosis and age programmable mice to derive a global interaction map of aging hallmarks$453,621
R01 · FY2023 · AG · contact PI
Role of epigenetic decay in cell senescence and aging$457,821
R01 · FY2022 · AG · contact PI
Uncovering the Human Secretome$1,186,500
DP1 · FY2021 · AG · contact PI
Tagmentation-based Indexing for Methylation Sequencing as a novel method of high-throughput methylation clock measurement$626,327
R21 · FY2021 · HG · contact PI
Role of epigenetic decay in cell senescence and aging$457,821
R01 · FY2021 · AG · contact PI
SIRT1 as a regulator of health and lifespan of mammals$373,815
R37 · FY2021 · AG · contact PI
Uncovering the Human Secretome$1,186,500
DP1 · FY2020 · AG · contact PI
Elucidating mechanisms of SIRT1 activation$487,967
R01 · FY2020 · DK · contact PI
SIRT1 as a regulator of health and lifespan of mammals$400,089
R37 · FY2020 · AG · contact PI
Uncovering the Human Secretome$1,186,500
DP1 · FY2019 · AG · contact PI
Elucidating mechanisms of SIRT1 activation$499,967
R01 · FY2019 · DK · contact PI
Role of epigenetic decay in cell senescence and aging$457,821
R01 · FY2019 · AG · contact PI
Role of epigenetic decay in cell senescence and aging$423,380
R01 · FY2019 · AG · contact PI
SIRT1 as a regulator of health and lifespan of mammals$400,089
R37 · FY2019 · AG · contact PI
Nicotinamide Mononucleotide (NMN) as a Novel Therapeutic in the Treatment of Oral Mucositis$211,875
R21 · FY2019 · DE · contact PI
Uncovering the Human Secretome$1,186,500
DP1 · FY2018 · AG · contact PI
Elucidating mechanisms of SIRT1 activation$508,312
R01 · FY2018 · DK · contact PI
Role of epigenetic decay in cell senescence and aging$457,821
R01 · FY2018 · AG · contact PI
SIRT1 as a regulator of health and lifespan of mammals$424,460
R37 · FY2018 · AG · contact PI
Nicotinamide Mononucleotide (NMN) as a Novel Therapeutic in the Treatment of Oral Mucositis$254,250
R21 · FY2018 · DE · contact PI
Uncovering the Human Secretome$1,186,500
DP1 · FY2017 · AG · contact PI
Elucidating mechanisms of SIRT1 activation$508,312
R01 · FY2017 · DK · contact PI
Role of epigenetic decay in cell senescence and aging$457,821
R01 · FY2017 · AG · contact PI
SIRT1 as a regulator of health and lifespan of mammals$449,168
R37 · FY2017 · AG · contact PI
Elucidating mechanisms of SIRT1 activation$515,939
R01 · FY2016 · DK · contact PI
SIRT1 as a regulator of health and lifespan of mammals$421,158
R37 · FY2016 · AG · contact PI
SIRT1 as a regulator of health and lifespan of mammals$408,523
R37 · FY2015 · AG · contact PI
SIRT1 as a regulator of health and lifespan of mammals$421,158
R37 · FY2014 · AG · contact PI
SIRT1 as a regulator of health and lifespan of mammals$397,994
R37 · FY2013 · AG · contact PI
SIRT1 as a regulator of health and lifespan of mammals$432,423
R37 · FY2012 · AG · contact PI
Role of Chromatin in Genomic Maintenance$259,719
R01 · FY2012 · AG · contact PI
SIRT as a regulator of health and lifespan of mammals$324,040
R01 · FY2011 · AG · contact PI
Role of Chromatin in Genomic Maintenance$259,860
R01 · FY2011 · AG · contact PI
SIRT as a regulator of health and lifespan of mammals$337,120
R01 · FY2010 · AG · contact PI
THE BIOLOGY AND UTILITY OF SIRT1- MEDIATED NEUROPROTECTION$304,173
P01 · FY2010 · AG · contact PI
Role of Chromatin in Genomic Maintenance$270,490
R01 · FY2010 · AG · contact PI
SIRT as a regulator of health and lifespan of mammals$340,274
R01 · FY2009 · AG · contact PI
THE BIOLOGY AND UTILITY OF SIRT1- MEDIATED NEUROPROTECTION$298,286
P01 · FY2009 · AG · contact PI
Role of Chromatin in Genomic Maintenance$273,362
R01 · FY2009 · AG · contact PI
SIRT as a regulator of health and lifespan of mammals$339,521
R01 · FY2008 · AG · contact PI
THE BIOLOGY AND UTILITY OF SIRT1- MEDIATED NEUROPROTECTION$289,606
P01 · FY2008 · AG · contact PI
Role of Chromatin in Genomic Maintenance$272,708
R01 · FY2008 · AG · contact PI
2009 Biology of Aging Gordon Research Conference$50,000
R13 · FY2008 · AG · contact PI
SIRT as a regulator of health and lifespan of mammals$346,707
R01 · FY2007 · AG · contact PI
THE BIOLOGY AND UTILITY OF SIRT1- MEDIATED NEUROPROTECTION$337,594
P01 · FY2007 · AG · contact PI
NAD+ control of transcriptional silencing and longevity$281,255
R01 · FY2007 · GM · contact PI
THE BIOLOGY AND UTILITY SIRT1- MEDIATED NEUROPROTECTION$311,200
P01 · FY2006 · AG · contact PI
NAD+ control of transcriptional silencing and longevity$289,655
R01 · FY2006 · GM · contact PI
Yeast screens for genetic & chemical mimetics of CR$165,907
R01 · FY2006 · AG · contact PI
NAD+ control of transcriptional silencing and longevity$296,625
R01 · FY2005 · GM
Role of Sgs1 DNA helicase in telomere maintenance$258,000
R01 · FY2005 · AG
Yeast screens for genetic &chemical mimetics of CR$169,900
R01 · FY2005 · AG
NAD+ control of transcriptional silencing and longevity$296,188
R01 · FY2004 · GM
Role of Sgs1 DNA helicase in telomere maintenance$258,000
R01 · FY2004 · AG
Yeast screens for genetic &chemical mimetics of CR$169,900
R01 · FY2004 · AG
NAD+ control of transcriptional silencing and longevity$303,360
R01 · FY2003 · GM
Role of Sgs1 DNA helicase in telomere maintenance$258,000
R01 · FY2003 · AG
Yeast screens for genetic &chemical mimetics of CR$169,900
R01 · FY2003 · AG
Role of Sgs1 DNA helicase in telomere maintenance$258,000
R01 · FY2002 · AG
Yeast screens for genetic &chemical mimetics of CR$165,007
R01 · FY2002 · AG
Role of Sgs1 DNA helicase in telomere maintenance$260,307
R01 · FY2001 · AG