← Leaderboards
Arlene H Sharpe
Harvard Medical School
$68,359,602
Attributed
$71,446,179
Total exposure
57
Grants
50
Lead (contact PI)
Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.
Funding over time
peak $10.4M · FY2005–25$20M$15M$10M$5M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25
Funding mix
By agency
NIH$126,276,682 · 59
By mechanism
P01$84,390,526 · 38
U19$19,568,998 · 4
R01$13,695,595 · 6
R37$4,147,667 · 1
U54$2,770,079 · 3
P30$664,667 · 4
Top collaborators
- Andrew H Lichtman4 shared
- Ryan J Sullivan4 shared
- Keith T Flaherty3 shared
- Marcia Haigis3 shared
- Nathalie Yr Agar2 shared
Most similar at Harvard Medical School
Same institution · by research overlap
- Daniel Rabin Brown$337,047
- Gerhard Wagner$49,510,293
- Gordon J Freeman$1,587,120
- John Edward Mindur$83,069
- Hazel C Levy$102,208
Others in their field
Top investigators on “T-Lymphocyte”
- Barton F Haynes · Duke University$296,833,570
- Lawrence Corey · Fred Hutchinson Cancer Center$270,341,865
- Dan H. Barouch · Fred Hutchinson Cancer Center$117,305,894
- Margaret Juliana McElrath · Fred Hutchinson Cancer Center$107,651,960
- Alessandro Sette · La Jolla Institute For Immunology$75,756,097
- Rama Rao Amara · Emory University$69,530,112
Research focus
T-LymphocytePathway InteractionsCellsResponseIn VivoT Cell ResponseAutoimmunityInsightImmune ResponseSignal TransductionBaseMalignant NeoplasmsImmuneMediatingReceptorCell TypeT-Cell ActivationLigandsInfectionResearch PersonnelTissuesPlayCell PhysiologyFunding
Grant awards (200)
Project 1 - Modulation of Tolerance and Autoimmunity by Inhibitory Receptors$642,410
P01 · FY2025 · AI · contact PI
Project 2: Elucidating how TIGIT agonists regulate CNS autoimmunity exacerbated by PD-1 blockade$631,388
P01 · FY2025 · AI · contact PI
Defining mechanisms to promote antitumor immunity by modulating one-carbon metabolism$562,761
R01 · FY2025 · CA · contact PI
Core B Gene Perturbation Core$273,972
P01 · FY2025 · AI · contact PI
Project 2: Elucidating how TIGIT agonists regulate CNS autoimmunity exacerbated by PD-1 blockade$631,388
P01 · FY2024 · AI · contact PI
Defining mechanisms to promote antitumor immunity by modulating one-carbon metabolism$534,622
R01 · FY2024 · CA · contact PI
Project 1 - Modulation of Tolerance and Autoimmunity by Inhibitory Receptors$456,302
P01 · FY2024 · AI · contact PI
Core B Gene Perturbation Core$273,970
P01 · FY2024 · AI · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,495,776
P01 · FY2023 · AI · contact PI
Project 2: T Cell Costimulation: Induction and Regulation of Autoimmunity$679,641
P01 · FY2023 · AI · contact PI
Project 1: Co-stimulation and Regulation of Anti-viral Immunity$637,015
P01 · FY2023 · AI · contact PI
Project 2: Elucidating how TIGIT agonists regulate CNS autoimmunity exacerbated by PD-1 blockade$631,388
P01 · FY2023 · AI · contact PI
Defining mechanisms to promote antitumor immunity by modulating one-carbon metabolism$580,136
R01 · FY2023 · CA · contact PI
Project 1 - Modulation of Tolerance and Autoimmunity by Inhibitory Receptors$456,302
P01 · FY2023 · AI · contact PI
Core C: Transgenic/Knockout Core$337,609
P01 · FY2023 · AI · contact PI
Core B Gene Perturbation Core$307,720
P01 · FY2023 · AI · contact PI
Admin Core$65,358
P01 · FY2023 · AI · contact PI
Program 11 Cancer Immunology$28,431
P30 · FY2023 · CA · contact PI
Mouse Engineering Core$1
P30 · FY2023 · CA · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,495,776
P01 · FY2022 · AI · contact PI
Project 2: T Cell Costimulation: Induction and Regulation of Autoimmunity$671,290
P01 · FY2022 · AI · contact PI
Project 1: Co-stimulation and Regulation of Anti-viral Immunity$660,826
P01 · FY2022 · AI · contact PI
Project 1 - Modulation of Tolerance and Autoimmunity by Inhibitory Receptors$456,302
P01 · FY2022 · AI · contact PI
Core C: Transgenic/Knockout Core$321,558
P01 · FY2022 · AI · contact PI
Project 2: Measuring and modeling the tumor and immune microenvironment before and during therapy and at the time of drug resistance$301,411
U54 · FY2022 · CA · contact PI
Admin Core$65,953
P01 · FY2022 · AI · contact PI
Program 11 Cancer Immunology$28,410
P30 · FY2022 · CA · contact PI
Mouse Engineering Core$1
P30 · FY2022 · CA · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,495,776
P01 · FY2021 · AI · contact PI
Defining regulators of immunity to acute infection using CRISPR screens$2,292,456
U19 · FY2021 · AI · contact PI
Project 1: CRISPR screens to discover regulators of CD8 and CD4 cell fates and function$865,355
U19 · FY2021 · AI · contact PI
Core D: Mouse Perturbation Core$812,789
U19 · FY2021 · AI · contact PI
Project 3: Integrative approach tounderstanding the mechanism ofcostimulation$662,499
P01 · FY2021 · AI · contact PI
Project 2: T Cell Costimulation: Induction and Regulation of Autoimmunity$624,460
P01 · FY2021 · AI · contact PI
Project 1: Co-stimulation and Regulation of Anti-viral Immunity$580,442
P01 · FY2021 · AI · contact PI
Project 1 - Modulation of Tolerance and Autoimmunity by Inhibitory Receptors$456,302
P01 · FY2021 · AI · contact PI
Abbreviated targeted therapy to improve anti-PD-1 inhibitor efficacy in melanoma$380,627
R01 · FY2021 · CA
Administrative Core$377,454
U19 · FY2021 · AI · contact PI
Project 2: Measuring and modeling the tumor and immune microenvironment before and during therapy and at the time of drug resistance$307,307
U54 · FY2021 · CA · contact PI
Core C: Transgenic/Knockout Core$270,082
P01 · FY2021 · AI · contact PI
Defining regulators of immunity to acute infection using CRISPR screens$109,850
U19 · FY2021 · AI · contact PI
Program 11: Cancer Immunology$71,143
P30 · FY2021 · CA · contact PI
Admin Core$65,356
P01 · FY2021 · AI · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,495,776
P01 · FY2020 · AI · contact PI
Defining regulators of immunity to acute infection using CRISPR screens$2,300,958
U19 · FY2020 · AI · contact PI
Project 3: Integrative approach tounderstanding the mechanism ofcostimulation$669,787
P01 · FY2020 · AI · contact PI
Project 2: T Cell Costimulation: Induction and Regulation of Autoimmunity$617,605
P01 · FY2020 · AI · contact PI
Project 1: Co-stimulation and Regulation of Anti-viral Immunity$581,348
P01 · FY2020 · AI · contact PI
Project 1: CRISPR screens to discover regulators of CD8 and CD4 cell fates and function$492,211
U19 · FY2020 · AI · contact PI
Project 1 - Modulation of Tolerance and Autoimmunity by Inhibitory Receptors$470,427
P01 · FY2020 · AI · contact PI
Administrative Core$391,659
U19 · FY2020 · AI · contact PI
Abbreviated targeted therapy to improve anti-PD-1 inhibitor efficacy in melanoma$380,517
R01 · FY2020 · CA
Core D: Mouse Perturbation Core$371,786
U19 · FY2020 · AI · contact PI
Project 2: Measuring and modeling the tumor and immune microenvironment before and during therapy and at the time of drug resistance$338,537
U54 · FY2020 · CA · contact PI
Core C: Transgenic/Knockout Core$296,196
P01 · FY2020 · AI · contact PI
Defining regulators of immunity to acute infection using CRISPR screens$109,850
U19 · FY2020 · AI · contact PI
Program 11: Cancer Immunology$71,030
P30 · FY2020 · CA · contact PI
Admin Core$47,043
P01 · FY2020 · AI · contact PI
Program 11: Cancer Immunology$2,948
P30 · FY2020 · CA · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,582,651
P01 · FY2019 · AI · contact PI
Defining regulators of immunity to acute infection using CRISPR screens$2,309,197
U19 · FY2019 · AI · contact PI
Project 3: Integrative approach tounderstanding the mechanism ofcostimulation$670,406
P01 · FY2019 · AI · contact PI
Project 2: T Cell Costimulation: Induction and Regulation of Autoimmunity$628,325
P01 · FY2019 · AI · contact PI
Project 1: Co-stimulation and Regulation of Anti-viral Immunity$596,255
P01 · FY2019 · AI · contact PI
Project 1: CRISPR screens to discover regulators of CD8 and CD4 cell fates and function$492,211
U19 · FY2019 · AI · contact PI
Modulation of Tolerance and Autoimmunity by Inhibitory Receptors$453,289
P01 · FY2019 · AI · contact PI
Administrative Core$422,956
U19 · FY2019 · AI · contact PI
Core D: Mouse Perturbation Core$371,786
U19 · FY2019 · AI · contact PI
Abbreviated targeted therapy to improve anti-PD-1 inhibitor efficacy in melanoma$370,800
R01 · FY2019 · CA
Project 1 - Integrating targeted and immune therapies for BRAF mutant colorectal cancer$352,875
P50 · FY2019 · CA · contact PI
Project 2: Measuring and modeling the tumor and immune microenvironment before and during therapy and at the time of drug resistance$324,561
U54 · FY2019 · CA · contact PI
Core C: Transgenic/Knockout Core$298,320
P01 · FY2019 · AI · contact PI
Program 11: Cancer Immunology$73,448
P30 · FY2019 · CA · contact PI
Admin Core$66,105
P01 · FY2019 · AI · contact PI
Program 11: Cancer Immunology$6,168
P30 · FY2019 · CA · contact PI
Defining regulators of immunity to acute infection using CRISPR screens$2,754,337
U19 · FY2018 · AI · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,282,140
P01 · FY2018 · AI · contact PI
Project 3: Integrative approach tounderstanding the mechanism ofcostimulation$626,414
P01 · FY2018 · AI · contact PI
Project 1: Costimulation and Regulation of Anti-viral Immunity$543,308
P01 · FY2018 · AI · contact PI
Project 1: CRISPR screens to discover regulators of CD8 and CD4 cell fates and function$506,646
U19 · FY2018 · AI · contact PI
Modulation of Tolerance and Autoimmunity by Inhibitory Receptors$460,382
P01 · FY2018 · AI · contact PI
P2: Defining and Visualizing Effects of Costimulation on Antiviral Immunity$445,032
P01 · FY2018 · AI · contact PI
In vivo role of CTLA-4 in Costimulation and Autoimmunity$423,750
R01 · FY2018 · AI · contact PI
Core D: Mouse Perturbation Core$406,914
U19 · FY2018 · AI · contact PI
Abbreviated targeted therapy to improve anti-PD-1 inhibitor efficacy in melanoma$398,271
R01 · FY2018 · CA
Project 2: Measuring and modeling the tumor and immune microenvironment before and during therapy and at the time of drug resistance$366,245
U54 · FY2018 · CA · contact PI
Administrative Core$346,450
U19 · FY2018 · AI · contact PI
Core C: Transgenic/Knockout Core$299,640
P01 · FY2018 · AI · contact PI
Program 11: Cancer Immunology$77,721
P30 · FY2018 · CA · contact PI
T Cell Costimulatory Pathways: Function and Interactions$56,669
P01 · FY2018 · AI · contact PI
Program 11: Cancer Immunology$11,430
P30 · FY2018 · CA · contact PI
Program 11: Cancer Immunology$5,849
P30 · FY2018 · CA · contact PI
Program 11: Cancer Immunology$5,123
P30 · FY2018 · CA · contact PI
Program 11: Cancer Immunology$3,833
P30 · FY2018 · CA · contact PI
Program 11: Cancer Immunology$1,602
P30 · FY2018 · CA · contact PI
Defining regulators of immunity to acute infection using CRISPR screens$2,462,939
U19 · FY2017 · AI · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,287,759
P01 · FY2017 · AI · contact PI
Project 3: Integrative approach tounderstanding the mechanism ofcostimulation$813,158
P01 · FY2017 · AI · contact PI
Project 1: CRISPR screens to discover regulators of CD8 and CD4 cell fates and function$622,869
U19 · FY2017 · AI · contact PI
Project 1: Costimulation and Regulation of Anti-viral Immunity$544,557
P01 · FY2017 · AI · contact PI
Core D: Mouse Perturbation Core$532,204
U19 · FY2017 · AI · contact PI
Modulation of Tolerance and Autoimmunity by Inhibitory Receptors$467,689
P01 · FY2017 · AI · contact PI
P2: Defining and Visualizing Effects of Costimulation on Antiviral Immunity$447,374
P01 · FY2017 · AI · contact PI
Protection of the Heart by PD-1 and PD-L1$424,839
R01 · FY2017 · HL
In vivo role of CTLA-4 in Costimulation and Autoimmunity$423,750
R01 · FY2017 · AI · contact PI
Core C: Transgenic/Knockout Core$300,264
P01 · FY2017 · AI · contact PI
Administrative Core$216,121
U19 · FY2017 · AI · contact PI
T Cell Costimulatory Pathways: Function and Interactions$57,293
P01 · FY2017 · AI · contact PI
Program 11: Cancer Immunology$47,297
P30 · FY2017 · CA · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,292,094
P01 · FY2016 · AI · contact PI
Role of Costimulation in Control of the Effector and Regulatory T Cell Balance$601,697
P01 · FY2016 · AI · contact PI
Project 1: Costimulation and Regulation of Anti-viral Immunity$533,498
P01 · FY2016 · AI · contact PI
Functional analyses of human and mouse SLAMF - SLAMF2 receptor/ligand interactio$531,800
P01 · FY2016 · AI · contact PI
P2: Defining and Visualizing Effects of Costimulation on Antiviral Immunity$489,644
P01 · FY2016 · AI · contact PI
Protection of the Heart by PD-1 and PD-L1$424,839
R01 · FY2016 · HL
In vivo role of CTLA-4 in Costimulation and Autoimmunity$423,750
R01 · FY2016 · AI · contact PI
Modulation of Tolerance and Autoimmunity by Inhibitory Receptors$398,698
P01 · FY2016 · AI · contact PI
Core C: Transgenic/Knockout Core$206,225
P01 · FY2016 · AI · contact PI
T Cell Costimulatory Pathways: Function and Interactions$39,614
P01 · FY2016 · AI · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,299,983
P01 · FY2015 · AI · contact PI
Modulation of Tolerance and Autoimmunity by Inhibitory Receptors$587,031
P01 · FY2015 · AI · contact PI
P2: Defining and Visualizing Effects of Costimulation on Antiviral Immunity$557,357
P01 · FY2015 · AI · contact PI
Functional analyses of human and mouse SLAMF - SLAMF2 receptor/ligand interactio$533,275
P01 · FY2015 · AI · contact PI
Project 1: Costimulation and Regulation of Anti-viral Immunity$529,207
P01 · FY2015 · AI · contact PI
In vivo role of CTLA-4 in Costimulation and Autoimmunity$423,750
R01 · FY2015 · AI · contact PI
In Vivo Function of the B7 Family of Costimulators$421,665
R37 · FY2015 · AI · contact PI
Protection of the Heart by PD-1 and PD-L1$417,886
R01 · FY2015 · HL
Role of Immune Regulatory Pathways in BRAF targeted therapy In melanoma$291,084
U54 · FY2015 · CA · contact PI
Core C: Transgenic/Knockout Core$201,146
P01 · FY2015 · AI · contact PI
T Cell Costimulatory Pathways: Function and Interactions$40,358
P01 · FY2015 · AI · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,194,909
P01 · FY2014 · AI · contact PI
Role of Costimulation in Control of the Effector and Regulatory T Cell Balance$658,362
P01 · FY2014 · AI · contact PI
Functional analyses of human and mouse SLAMF - SLAMF2 receptor/ligand interactio$533,275
P01 · FY2014 · AI · contact PI
Project 1: Costimulation and Regulation of Anti-viral Immunity$509,755
P01 · FY2014 · AI · contact PI
P2: Defining and Visualizing Effects of Costimulation on Antiviral Immunity$506,282
P01 · FY2014 · AI · contact PI
Protection of the Heart by PD-1 and PD-L1$442,623
R01 · FY2014 · HL
In vivo role of CTLA-4 in Costimulation and Autoimmunity$423,750
R01 · FY2014 · AI · contact PI
In Vivo Function of the B7 Family of Costimulators$421,665
R37 · FY2014 · AI · contact PI
Role of Immune Regulatory Pathways in BRAF targeted therapy In melanoma$288,077
U54 · FY2014 · CA · contact PI
Core C: Transgenic/Knockout Core$191,758
P01 · FY2014 · AI · contact PI
Regulation of chronic viral infection by co-inhibitory pathways$134,927
R01 · FY2014 · AI · contact PI
Consortia for High-Throughput-Enabled Structural Biology Partnerships (U01)$52,705
U01 · FY2014 · GM · contact PI
T Cell Costimulatory Pathways: Function and Interactions$38,475
P01 · FY2014 · AI · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,087,312
P01 · FY2013 · AI · contact PI
Role of Costimulation in Control of the Effector and Regulatory T Cell Balance$613,015
P01 · FY2013 · AI · contact PI
Costimulation and Regulation of Anti-Microbial Immunity$467,047
P01 · FY2013 · AI · contact PI
In Vivo Function of the B7 Family of Costimulators$396,365
R37 · FY2013 · AI · contact PI
Regulatory T Cell Compartment$304,487
U54 · FY2013 · CA · contact PI
Transgenic/Knockout$217,574
P01 · FY2013 · AI · contact PI
Regulation of chronic viral infection by co-inhibitory pathways$126,831
R01 · FY2013 · AI · contact PI
Administrative$71,689
P01 · FY2013 · AI · contact PI
Consortia for High-Throughput-Enabled Structural Biology Partnerships (U01)$50,860
U01 · FY2013 · GM · contact PI
Functional analyses of human and mouse SLAMF - SLAMF2 receptor/ligand interactio$48,066
P01 · FY2013 · AI · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,184,474
P01 · FY2012 · AI · contact PI
Role of Costimulation in Control of the Effector and Regulatory T Cell Balance$654,695
P01 · FY2012 · AI · contact PI
Functional analyses of human and mouse SLAMF - SLAMF2 receptor/ligand interactio$541,066
P01 · FY2012 · AI · contact PI
Costimulation and Regulation of Anti-Microbial Immunity$491,178
P01 · FY2012 · AI · contact PI
In Vivo Function of the B7 Family of Costimulators$421,665
R37 · FY2012 · AI · contact PI
In vivo role of CTLA-4 in Costimulation and Autoimmunity$415,317
R01 · FY2012 · AI · contact PI
Visualizing Effects of Costimulation on Antiviral Immunity$411,538
P01 · FY2012 · AI · contact PI
Role of Immune Regulatory Pathways in BRAF Targeted Therapy In Melanoma$248,370
U54 · FY2012 · CA · contact PI
Transgenic/Knockout$231,777
P01 · FY2012 · AI · contact PI
Regulation of chronic viral infection by co-inhibitory pathways$134,927
R01 · FY2012 · AI · contact PI
Administrative$93,095
P01 · FY2012 · AI · contact PI
Consortia for High-Throughput-Enabled Structural Biology Partnerships (U01)$52,705
U01 · FY2012 · GM · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,171,092
P01 · FY2011 · AI · contact PI
Role of Costimulation in Control of the Effector and Regulatory T Cell Balance$628,958
P01 · FY2011 · AI · contact PI
Costimulation and Regulation of Anti-Microbial Immunity$472,899
P01 · FY2011 · AI · contact PI
In Vivo Function of the B7 Family of Costimulators$421,665
R37 · FY2011 · AI · contact PI
In vivo role of CTLA-4 in Costimulation and Autoimmunity$415,317
R01 · FY2011 · AI · contact PI
Visualizing Effects of Costimulation on Antiviral Immunity$408,965
P01 · FY2011 · AI · contact PI
Transgenic/Knockout$235,335
P01 · FY2011 · AI · contact PI
Administrative$147,996
P01 · FY2011 · AI · contact PI
Regulation of chronic viral infection by co-inhibitory pathways$134,927
R01 · FY2011 · AI · contact PI
Consortia for High-Throughput-Enabled Structural Biology Partnerships (U01)$53,160
U01 · FY2011 · GM · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$2,160,908
P01 · FY2010 · AI · contact PI
Role of Costimulation in Control of the Effector and Regulatory T Cell Balance$631,032
P01 · FY2010 · AI · contact PI
Costimulation and Regulation of Anti-Microbial Immunity$448,152
P01 · FY2010 · AI · contact PI
In vivo role of CTLA-4 in Costimulation and Autoimmunity$419,513
R01 · FY2010 · AI · contact PI
Visualizing Effects of Costimulation on Antiviral Immunity$407,712
P01 · FY2010 · AI · contact PI
In Vivo Function of the B7 Family of Costimulators$399,608
R37 · FY2010 · AI · contact PI
Functional anaylses of the CDS48 and SLAMF8 receptors ........$367,672
P01 · FY2010 · AI · contact PI
Transgenic/Knockout$237,486
P01 · FY2010 · AI · contact PI
Regulation of chronic viral infection by co-inhibitory pathways$153,665
R01 · FY2010 · AI · contact PI
Administrative$149,393
P01 · FY2010 · AI · contact PI
Consortia for High-Throughput-Enabled Structural Biology Partnerships (U01)$53,907
U01 · FY2010 · GM · contact PI
T Cell Costimulatory Pathways: Functions and Interactions$1,705,049
P01 · FY2009 · AI · contact PI
Role of B7H4 and CD48 in EAE$457,187
P01 · FY2009 · AI · contact PI
In vivo role of CTLA-4 in Costimulation and Autoimmunity$423,438
R01 · FY2009 · AI · contact PI
Regulation of chronic viral infection by co-inhibitory pathways$422,938
R56 · FY2009 · AI · contact PI
In Vivo Function of the B7 Family of Costimulators$403,644
R37 · FY2009 · AI · contact PI
Visualizing Effects of Costimulation on Antiviral Immunity$399,833
P01 · FY2009 · AI · contact PI
Functional anaylses of the CDS48 and SLAMF8 receptors ........$362,425
P01 · FY2009 · AI · contact PI
Transgenic/Knockout$236,816
P01 · FY2009 · AI · contact PI
Administrative$148,363
P01 · FY2009 · AI · contact PI
In Vivo Function of the B7 Family of Costimulators$22,535
R37 · FY2009 · AI · contact PI
Costimulation and Regulation of Anti-Microbial Immunity$2
P01 · FY2009 · AI · contact PI
Role of B7H4 and CD48 in EAE$455,401
P01 · FY2008 · AI · contact PI
Visualizing Effects of Costimulation on Antiviral Immunity$431,142
P01 · FY2008 · AI · contact PI
In vivo role of CTLA-4 in Costimulation and Autoimmunity$422,500
R01 · FY2008 · AI · contact PI