← Leaderboards
Michael J Eck
Dana-Farber Cancer Inst
$25,871,961
Attributed
$29,904,620
Total exposure
23
Grants
21
Lead (contact PI)
Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.
Funding over time
peak $2.1M · FY2005–25$2.5M$1.9M$1.3M$625K$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25
Funding mix
By agency
NIH$29,904,620 · 23
By mechanism
R01$15,200,442 · 5
R35$7,379,880 · 1
P01$4,900,170 · 3
U19$938,455 · 2
P41$685,522 · 10
R56$482,533 · 1
Top collaborators
- Matthew L Meyerson11 shared
- Nathanael Schiander Gray10 shared
Most similar at Dana-Farber Cancer Inst
Same institution · by research overlap
- Rani E George$9,003,170
- Nathanael Schiander Gray$36,761,550
- Kornelia Polyak$28,582,691
- Timothy R Rebbeck$50,819,475
- Daphne A. Haas-Kogan$5,585,485
Others in their field
Top investigators on “Structure”
- David Heimbrook · Leidos Biomedical Research, Inc.$475,333,582
- Barton F Haynes · Duke University$444,977,767
- Lawrence Corey · Fred Hutchinson Cancer Center$334,646,086
- Gary D Acton · University Of California-Davis$320,373,312
- Mitchell J Malone · Texas A&M Research Foundation$320,373,312
- Michael David Hughes · Harvard University D/B/A Harvard School Of Public Health$315,257,203
Research focus
StructureMutationMutantPhosphotransferasesProteinsEpidermal Growth Factor ReceptorComplexBaseBiochemicalMalignant NeoplasmsInhibitor/AntagonistStructural BiologyReceptorSignal TransductionLaboratoriesResistanceLeadIn VitroProtein Tyrosine KinaseNon-Small-Cell Lung CarcinomaRegulationTargeted TreatmentBindingProtein Kinase
Grant awards (87)
Structure, mechanism, and pharmacology of BRAF and its partners in the RAS/RAF/MAP kinase pathway$1,068,000
R35 · FY2025 · CA · contact PI
Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M$490,549
R01 · FY2025 · CA · contact PI
Small molecule inhibitors with a therapeutic window for EGFR signaling variants in glioblastoma$200,578
U19 · FY2025 · CA · contact PI
Structure, mechanism, and pharmacology of BRAF and its partners in the RAS/RAF/MAP kinase pathway$1,014,601
R35 · FY2024 · CA · contact PI
Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M$466,022
R01 · FY2024 · CA · contact PI
Small molecule inhibitors with a therapeutic window for EGFR signaling variants in glioblastoma$177,362
U19 · FY2024 · CA · contact PI
Structure, mechanism, and pharmacology of BRAF and its partners in the RAS/RAF/MAP kinase pathway$1,046,639
R35 · FY2023 · CA · contact PI
Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M$480,738
R01 · FY2023 · CA · contact PI
Project 1--Targeted therapies for pediatric low-grade astrocytoma (Eck/Wright/Haas)$317,618
P50 · FY2023 · CA · contact PI
Small molecule inhibitors with a therapeutic window for EGFR signaling variants in glioblastoma$186,507
U19 · FY2023 · CA · contact PI
Structure, mechanism, and pharmacology of BRAF and its partners in the RAS/RAF/MAP kinase pathway$1,046,640
R35 · FY2022 · CA · contact PI
Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M$480,738
R01 · FY2022 · CA · contact PI
Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma$260,727
R01 · FY2022 · CA · contact PI
Small molecule inhibitors with a therapeutic window for EGFR signaling variants in glioblastoma$177,839
U19 · FY2022 · CA · contact PI
Structure, mechanism, and pharmacology of BRAF and its partners in the RAS/RAF/MAP kinase pathway$1,068,000
R35 · FY2021 · CA · contact PI
Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M$490,549
R01 · FY2021 · CA · contact PI
Core B: Structure and Biochemistry$240,508
P01 · FY2021 · CA · contact PI
Small molecule inhibitors with a therapeutic window for EGFR signaling variants in glioblastoma$196,169
U19 · FY2021 · CA · contact PI
Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma$108,012
R01 · FY2021 · CA · contact PI
Structure, mechanism, and pharmacology of BRAF and its partners in the RAS/RAF/MAP kinase pathway$1,068,000
R35 · FY2020 · CA · contact PI
Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M$467,339
R01 · FY2020 · CA · contact PI
Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma$374,063
R01 · FY2020 · CA · contact PI
Core B: Structure and Biochemistry$240,508
P01 · FY2020 · CA · contact PI
Structure, mechanism, and pharmacology of BRAF and its partners in the RAS/RAF/MAP kinase pathway$1,068,000
R35 · FY2019 · CA · contact PI
Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M$453,318
R01 · FY2019 · CA · contact PI
Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma$362,840
R01 · FY2019 · CA · contact PI
Core B: Structure and Biochemistry$240,508
P01 · FY2019 · CA · contact PI
Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M$425,882
R01 · FY2018 · CA · contact PI
Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma$374,063
R01 · FY2018 · CA · contact PI
Core B: Structure and Biochemistry$240,508
P01 · FY2018 · CA · contact PI
Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M$425,882
R01 · FY2017 · CA · contact PI
Structure and regulation of non-receptor tyrosine kinases$415,200
R01 · FY2017 · GM · contact PI
Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma$374,063
R01 · FY2017 · CA · contact PI
Core B: Structure and Biochemistry$240,508
P01 · FY2017 · CA · contact PI
Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M$425,882
R01 · FY2016 · CA · contact PI
Structure and regulation of non-receptor tyrosine kinases$415,200
R01 · FY2016 · GM · contact PI
Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma$326,813
R01 · FY2016 · CA · contact PI
Structure$277,251
P01 · FY2016 · CA · contact PI
Structure and regulation of non-receptor tyrosine kinases$415,200
R01 · FY2015 · GM · contact PI
Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma$326,813
R01 · FY2015 · CA · contact PI
Structure$277,251
P01 · FY2015 · CA · contact PI
Structure and regulation of non-receptor tyrosine kinases$415,200
R01 · FY2014 · GM · contact PI
Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma$317,009
R01 · FY2014 · CA · contact PI
Structure$268,933
P01 · FY2014 · CA · contact PI
Structural Biology of Formin Proteins$396,083
R01 · FY2013 · GM · contact PI
Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma$307,204
R01 · FY2013 · CA · contact PI
Structure$219,166
P01 · FY2013 · CA · contact PI
Structural Biology of Formin Proteins$410,448
R01 · FY2012 · GM · contact PI
Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma$326,813
R01 · FY2012 · CA · contact PI
Structure$298,924
P01 · FY2012 · CA · contact PI
Structural Biology of Formin Proteins$410,449
R01 · FY2011 · GM · contact PI
MOLECULAR INTERACTIONS REGULATING INTRACELLULAR SIGNALING$18,283
P41 · FY2011 · RR · contact PI
Structural Biology of Formin Proteins$415,990
R01 · FY2010 · GM · contact PI
Structural biology of kinase signaling in T-cells$256,000
R01 · FY2010 · CA · contact PI
CRYSTAL STRUCTURE OF A COILED COIL DOMAIN OF HUMAN P160ROCK$46,851
P41 · FY2010 · RR · contact PI
CRYSTAL STRUCTURE OF DRUG-RESISTANT EGFR MUTANT IN COMPLEX WITH NEW INHIBITORS$43,242
P41 · FY2010 · RR · contact PI
STRUCTURAL STUDIES OF THE ACTIN ORGANIZERS SPIRE AND FMN2$18,023
P41 · FY2010 · RR · contact PI
Focal Adhesion Kinase$597,509
P01 · FY2009 · HL · contact PI
Structural Biology of Formin Proteins$482,533
R56 · FY2009 · GM · contact PI
Structural biology of kinase signaling in T-cells$256,000
R01 · FY2009 · CA · contact PI
STRUCTURAL BIOLOGY OF SIGNALING AND THE ACTIN CYTOSKELETON$79,273
P41 · FY2009 · RR · contact PI
MACCHESS PROGRAM FOR MICROCRYSTALLOGRAPHY/MEMBRANE PROTEIN CRYSTALS$6,718
P41 · FY2009 · RR · contact PI
Focal Adhesion Kinase$569,044
P01 · FY2008 · HL · contact PI
Structural biology of kinase signaling in T-cells$256,000
R01 · FY2008 · CA · contact PI
STRUCTURAL BIOLOGY OF FORMIN PROTEINS$50,599
P41 · FY2008 · RR · contact PI
Focal Adhesion Kinase$400,279
P01 · FY2007 · HL · contact PI
Structural Biology of Formin Proteins$364,813
R01 · FY2007 · GM · contact PI
Structural biology of kinase signaling in T-cells$256,000
R01 · FY2007 · CA · contact PI
Focal Adhesion Kinase$400,983
P01 · FY2006 · HL · contact PI
Structural Biology of Formin Proteins$375,709
R01 · FY2006 · GM · contact PI
Structural biology of kinase signaling in T-cells$262,361
R01 · FY2006 · CA · contact PI
STRUCTURAL BIOLOGY OF FORMIN PROTEINS$9,548
P41 · FY2006 · RR · contact PI
Focal Adhesion Kinase$388,290
P01 · FY2005 · HL
Structural Biology of Formin Proteins$384,750
R01 · FY2005 · GM
MACCHESS FOR IMPLEMENTATION OF XRAY DETECTORS IN MACROMOLECULAR CRYSTALLOGRAPHY$45,216
P41 · FY2005 · RR
STRUCTURAL BIOLOGY OF FORMIN PROTEINS$12,248
P41 · FY2005 · RR
Structural Biology of Formin Proteins$379,319
R01 · FY2004 · GM
CRYSTALLOGRAPHIC ANALYSIS OF CBL AND CBL/ZAP-70 COMPLEX$38,475
R01 · FY2004 · CA
CRYSTAL STRUCTURE OF BNIL1 FORMING MUTANT$23,969
P41 · FY2004 · RR
MACCHESS: XRAY DETECTORS/MACROMOLECULE CRYSTALLOGRAPHY$11,160
P41 · FY2004 · RR
CRYSTALLOGRAPHIC ANALYSIS OF CBL AND CBL/ZAP-70 COMPLEX$264,306
R01 · FY2003 · CA
CRYSTALLOGRAPHIC ANALYSIS OF CBL AND CBL/ZAP-70 COMPLEX$256,608
R01 · FY2002 · CA
MACCHESS CONSORTIUM FOR XRAY DETECTORS IN MACROMOLECULAR CRYSTALLOGRAPHY$142,703
P41 · FY2002 · RR
CRYSTALLOGRAPHIC ANALYSIS OF CBL AND CBL/ZAP-70 COMPLEX$249,136
R01 · FY2001 · CA
MACCHESS CONSORTIUM FOR XRAY DETECTORS IN MACROMOLECULAR CRYSTALLOGRAPHY$142,703
P41 · FY2001 · RR
CRYSTALLOGRAPHIC ANALYSIS OF CBL AND CBL/ZAP-70 COMPLEX$241,876
R01 · FY2000 · CA
MACCHESS CONSORTIUM FOR XRAY DETECTORS IN MACROMOLECULAR CRYSTALLOGRAPHY$34,986
P41 · FY2000 · RR