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Geoffrey A Chang

Scripps Research Institute

$27,252,519
Attributed
$38,203,596
Total exposure
44
Grants
25
Lead (contact PI)

Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.

Funding over time

peak $5.4M · FY200525
$10M$7.5M$5M$2.5M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25

Funding mix

By agency

NIH$50,435,138 · 45

By mechanism

R01$27,194,741 · 14
U54$15,498,581 · 2
P50$2,495,108 · 1
R21$2,485,115 · 5
P42$1,041,440 · 1
R56$1,023,775 · 1

Most similar at Scripps Research Institute

Same institution · by research overlap

Others in their field

Top investigators on “Structure

Research focus

StructurePharmaceutical PreparationsProteinsBaseMolecularCrystallizationFamilyResolutionInhibitor/AntagonistMembrane ProteinsCellsProtein StructureLigandsMapsNanobodiesBindingStructural BiologyLaboratoriesMulti-Drug ResistanceResearch PersonnelComplexBinding (Molecular Function)AnimalsUnited States National Institutes Of Health

Grant awards (122)

MiMA: Mother-infant Metabolite-transporter Atlas$672,127
R01 · FY2025 · HD · contact PI
Development of functionalized SARM1 nanobodies for glaucoma$643,952
R01 · FY2025 · EY
Biosynthesis of marine terpenoid natural products$480,689
R01 · FY2025 · GM
MiMA: Mother-infant Metabolite-transporter Atlas$46,371
R01 · FY2025 · HD · contact PI
MiMA: Mother-infant Metabolite-transporter Atlas$697,803
R01 · FY2024 · HD · contact PI
Biosynthesis of marine terpenoid natural products$489,950
R01 · FY2024 · GM
Optimization of CAR-Bacteria for Oral Cancer$175,429
R21 · FY2024 · CA · contact PI
Equipment Supplement - Biosynthesis of marine terpenoid natural products$86,786
R01 · FY2024 · GM
TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation$759,909
R01 · FY2023 · NS
Biosynthesis of marine terpenoid natural products$503,990
R01 · FY2023 · GM
Optimization of CAR-Bacteria for Oral Cancer$221,595
R21 · FY2023 · CA · contact PI
TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation$782,427
R01 · FY2022 · NS
Identity, mechanisms and early life impacts of transporter interfering compounds$539,421
R01 · FY2022 · ES
Synthetically-evolved and engineered Nanobodies selective for Cb isoforms of PKA$434,500
R21 · FY2022 · AG
TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation$759,191
R01 · FY2021 · NS
Identity, mechanisms and early life impacts of transporter interfering compounds$558,621
R01 · FY2021 · ES
Development of low-cost, field-ready nanobodies against snake venom$255,869
R41 · FY2021 · GM
Project 5: Discovery of Protein Sensors and Switches for Detection of Environmental Toxicants$219,870
P42 · FY2021 · ES · contact PI
Nanobody inhibitors of proton-sensing G protein-coupled receptors$157,792
R03 · FY2021 · TR · contact PI
Identity, mechanisms and early life impacts of transporter interfering compounds$642,605
R01 · FY2020 · ES
Down syndrome, early cataracts, eye diseases, and beta-amyloid conformers$196,979
R21 · FY2020 · EY · contact PI
Project 5: Discovery of Protein Sensors and Switches for Detection of Environmental Toxicants$196,825
P42 · FY2020 · ES · contact PI
Down syndrome, early cataracts, eye diseases, and beta-amyloid conformers$116,612
R21 · FY2020 · EY · contact PI
Identity, mechanisms and early life impacts of transporter interfering compounds$605,476
R01 · FY2019 · ES
Down syndrome, early cataracts, eye diseases, and beta-amyloid conformers$236,250
R21 · FY2019 · EY · contact PI
Project 5: Discovery of Protein Sensors and Switches for Detection of Environmental Toxicants$227,397
P42 · FY2019 · ES · contact PI
Identity, mechanisms and early life impacts of transporter interfering compounds$74,291
R01 · FY2019 · ES
Identity, mechanisms and early life impacts of transporter interfering compounds$621,161
R01 · FY2018 · ES
Targeting the mitochondrial pyruvate carrier to treat neurodegenerative disease$584,104
R01 · FY2018 · NS
A novel platform for genetically-encoded optical neuropeptide sensors (NEONS)$232,500
R21 · FY2018 · EY
Project 5: Discovery of Protein Sensors and Switches for Detection of Environmental Toxicants$197,574
P42 · FY2018 · ES · contact PI
A novel platform for genetically-encoded optical neuropeptide sensors (NEONS)$196,250
R21 · FY2018 · EY
A novel platform for genetically-encoded optical neuropeptide sensors (NEONS)$80,000
R21 · FY2018 · EY
Targeting the mitochondrial pyruvate carrier to treat neurodegenerative disease$584,104
R01 · FY2017 · NS
A novel platform for genetically-encoded optical neuropeptide sensors (NEONS)$232,500
R21 · FY2017 · EY
Structure-based optimization of a novel pharmacological chaperone therapy for MPSIIIC$224,873
R41 · FY2017 · HD
Project 5: Discovery of Protein Sensors and Switches for Detection of Environmental Toxicants$199,774
P42 · FY2017 · ES · contact PI
Molecular Organization of Renal and Hepatic Organic Cation Transporters$595,701
R01 · FY2016 · DK
Targeting the mitochondrial pyruvate carrier to treat neurodegenerative disease$584,104
R01 · FY2016 · NS
Structure and function of ABC transporters to understand persistence of global ma$167,947
R01 · FY2016 · ES
Targeting the mitochondrial pyruvate carrier to treat neurodegenerative disease$584,104
R01 · FY2015 · NS
Molecular Organization of Renal and Hepatic Organic Cation Transporters$532,109
R01 · FY2015 · DK
Structure and function of ABC transporters to understand persistence of global ma$170,260
R01 · FY2015 · ES
Molecular Organization of Renal and Hepatic Organic Cation Transporters$63,402
R01 · FY2015 · DK
TransportPDB: Center for the X-ray Structure Determination of Human Transporters$2,303,278
U54 · FY2014 · GM
Targeting the mitochondrial pyruvate carrier to treat neurodegenerative disease$588,919
R01 · FY2014 · NS
Molecular Organization of Renal and Hepatic Organic Cation Transporters$532,109
R01 · FY2014 · DK
TransportPDB: Center for the X-ray Structure Determination of Human Transporters$510,468
U54 · FY2014 · GM · contact PI
Molecular Organization of the Organic Cation-Proton Exchanger, MATE1$475,969
R01 · FY2014 · DK
Structure and function of ABC transporters to understand persistence of global ma$172,382
R01 · FY2014 · ES
TransportPDB: Center for the X-ray Structure Determination of Human Transporters$2,469,542
U54 · FY2013 · GM
Molecular Organization of Renal and Hepatic Organic Cation Transporters$557,859
R01 · FY2013 · DK
TransportPDB: Center for the X-ray Structure Determination of Human Transporters$545,327
U54 · FY2013 · GM · contact PI
Molecular Organization of the Organic Cation-Proton Exchanger, MATE1$459,309
R01 · FY2013 · DK
Affinity maturation via in vitro evolution at the lab bench-top$296,159
R01 · FY2013 · GM · contact PI
Structural biology and high resolution studies of P-glycoprotein$284,667
R01 · FY2013 · GM · contact PI
Structure and function of ABC transporters to understand persistence of global ma$174,257
R01 · FY2013 · ES
TransportPDB: Center for the X-ray Structure Determination of Human Transporters$2,530,133
U54 · FY2012 · GM
TransportPDB: Center for the X-ray Structure Determination of Human Transporters$650,436
U54 · FY2012 · GM · contact PI
Molecular Organization of the Organic Cation-Proton Exchanger, MATE1$475,969
R01 · FY2012 · DK
Affinity maturation via in vitro evolution at the lab bench-top$233,599
R01 · FY2012 · GM · contact PI
Structural biology and high resolution studies of P-glycoprotein$189,428
R01 · FY2012 · GM · contact PI
Structure and function of ABC transporters to understand persistence of global ma$174,731
R01 · FY2012 · ES
Structural biology and high resolution studies of P-glycoprotein$104,135
R01 · FY2012 · GM · contact PI
Affinity maturation via in vitro evolution at the lab bench-top$90,408
R01 · FY2012 · GM · contact PI
TransportPDB: Center for the X-ray Structure Determination of Human Transporters$2,655,017
U54 · FY2011 · GM
TransportPDB: Center for the X-ray Structure Determination of Human Transporters$810,797
U54 · FY2011 · GM · contact PI
Molecular Organization of the Organic Cation-Proton Exchanger, MATE1$475,969
R01 · FY2011 · DK
Affinity maturation via in vitro evolution at the lab bench-top$376,002
R01 · FY2011 · GM · contact PI
Structural biology and high resolution studies of P-glycoprotein$358,201
R01 · FY2011 · GM · contact PI
GEOFF CHANG PRT-CRYSTALLOGRAPHY OF INTEGRAL MEMBRANE PROTEINS$3,574
P41 · FY2011 · RR · contact PI
TransportPDB: Center for the X-ray Structure Determination of Human Transporters$2,273,572
U54 · FY2010 · GM
Inhibition of Malaria Chloroquine Resistance Transporters$1,023,775
R56 · FY2010 · AI
TransportPDB: Center for the X-ray Structure Determination of Human Transporters$750,011
U54 · FY2010 · GM · contact PI
Molecular Organization of the Organic Cation-Proton Exchanger, MATE1$590,428
R01 · FY2010 · DK
Structural biology and high resolution studies of P-glycoprotein$384,294
R01 · FY2010 · GM · contact PI
Affinity maturation via in vitro evolution at the lab bench-top$379,800
R01 · FY2010 · GM · contact PI
GEOFF CHANG PRT-CRYSTALLOGRAPHY OF INTEGRAL MEMBRANE PROTEINS$3,735
P41 · FY2010 · RR · contact PI
STRUCTURE OF MULTIDRUG TRANSPORTERS$692
P41 · FY2010 · RR · contact PI
Structural Biology and Inhibition of MDR ABC Transporters$451,490
R01 · FY2009 · GM · contact PI
Structural Biology and Inhibition of MDR ABC Transporters$275,846
R01 · FY2009 · GM · contact PI
GEOFF CHANG PRT-CRYSTALLOGRAPHY OF INTEGRAL MEMBRANE PROTEINS$3,302
P41 · FY2009 · RR · contact PI
STRUCTURE OF MULTIDRUG TRANSPORTERS$1,044
P41 · FY2009 · RR · contact PI
Innovative Membrane Protein Tech: Sample Preparation (IMPSP)$678,420
P50 · FY2008 · GM · contact PI
Structural Biology and Inhibition of MDR ABC Transporters$438,795
R01 · FY2008 · GM · contact PI
Crystallography of MATE Transporters$341,393
R01 · FY2008 · GM · contact PI
GEOFF CHANG PRT-CRYSTALLOGRAPHY OF INTEGRAL MEMBRANE PROTEINS$1,534
P41 · FY2008 · RR · contact PI
CRYSTALLIZATION OF INTEGRAL MEMBRANE PROTEINS$573
P41 · FY2008 · RR · contact PI
STRUCTURE OF MULTIDRUG TRANSPORTERS$184
P41 · FY2008 · RR · contact PI
Innovative Membrane Protein Tech: Sample Preparation (IMPSP)$691,566
P50 · FY2007 · GM · contact PI
Structural Biology and Inhibition of MDR ABC Transporters$430,866
R01 · FY2007 · GM · contact PI
Crystallography of MATE Transporters$334,907
R01 · FY2007 · GM · contact PI
GEOFF CHANG PRT-CRYSTALLOGRAPHY OF INTEGRAL MEMBRANE PROTEINS$5,752
P41 · FY2007 · RR · contact PI
CRYSTALLIZATION OF INTEGRAL MEMBRANE PROTEINS$1,786
P41 · FY2007 · RR · contact PI
STRUCTURE OF MULTIDRUG TRANSPORTERS$199
P41 · FY2007 · RR · contact PI
Structural Biology and Inhibition of MDR ABC Transporters$431,288
R01 · FY2006 · GM · contact PI
Innovative Membrane Protein Tech: Sample Preparation IMP$391,226
P50 · FY2006 · GM · contact PI
X-ray Structures of Small MDR Efflux Pumps$366,578
R01 · FY2006 · GM · contact PI
Crystallography of MATE Transporters$344,910
R01 · FY2006 · GM · contact PI
GEOFF CHANG PRT-CRYSTALLOGRAPHY OF INTEGRAL MEMBRANE PROTEINS$5,349
P41 · FY2006 · RR · contact PI
CRYSTALLIZATION OF INTEGRAL MEMBRANE PROTEINS$3,639
P41 · FY2006 · RR · contact PI
Innovative Membrane Protein Tech: Sample Preparation IMP$379,890
P50 · FY2005 · GM
X-ray Structures of Small MDR Efflux Pumps$375,400
R01 · FY2005 · GM
Crystallography of MATE Transporters$353,210
R01 · FY2005 · GM
CRYSTALLOGRAPHY OF MULTI-DRUG RESISTANT-ABC TRANSPORTERS$101,325
R01 · FY2005 · GM
CRYSTALLIZATION OF INTEGRAL MEMBRANE PROTEINS$7,144
P41 · FY2005 · RR
PRT-CRYSTALLOGRAPHY OF INTEGRAL MEMBRANE PROTEINS$6,668
P41 · FY2005 · RR
CRYSTALLOGRAPHY OF MULTI-DRUG RESISTANT-ABC TRANSPORTERS$394,409
R01 · FY2004 · GM
X-ray Structures of Small MDR Efflux Pumps$375,400
R01 · FY2004 · GM
Innovative Membrane Protein Tech: Sample Preparation IMP$354,006
P50 · FY2004 · GM
CRYSTALLOGRAPHY OF MDR TRANSPORTERS$6,226
P41 · FY2004 · RR
GEOFF CHANG PRT-CRYSTALLOGRAPHY OF INTEGRAL MEMBRANE PROTEINS$3,728
P41 · FY2004 · RR
CRYSTALLOGRAPHY OF DRUG TRANSPORTER$1,390
P41 · FY2004 · RR
STRUCTURE OF SMALL EFFLUX MULTIDRUG TRANSPORTER$1,325
P41 · FY2004 · RR
CRYSTALLOGRAPHY OF MULTI-DRUG RESISTANT-ABC TRANSPORTERS$383,834
R01 · FY2003 · GM
X-ray Structures of Small MDR Efflux Pumps$375,400
R01 · FY2003 · GM
CRYSTALLOGRAPHY OF MULTI-DRUG RESISTANT-ABC TRANSPORTERS$373,569
R01 · FY2002 · GM
Crystallography of Multi-Drug Resistant MFS Transporters$185,200
R21 · FY2002 · GM
CRYSTALLOGRAPHY OF MULTI-DRUG RESISTANT-ABC TRANSPORTERS$154,000
R01 · FY2002 · GM
CRYSTALLOGRAPHY OF MULTI-DRUG RESISTANT-ABC TRANSPORTERS$348,093
R01 · FY2001 · GM
Crystallography of Multi-Drug Resistant MFS Transporters$177,300
R21 · FY2001 · GM
CRYSTALLOGRAPHY OF MULTI-DRUG RESISTANT-ABC TRANSPORTERS$338,829
R01 · FY2000 · GM