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Thomas E Hughes

Yale University

$6,086,398
Attributed
$11,966,276
Total exposure
17
Grants
3
Lead (contact PI)

Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.

Funding over time

peak $1.8M · FY200625
$2M$1.5M$1M$500K$0
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25

Funding mix

By agency

NIH$11,966,276 · 17

By mechanism

R44$4,458,769 · 4
R01$2,898,109 · 2
U01$2,040,288 · 1
R43$1,156,382 · 4
R21$695,980 · 2
T32$306,488 · 1

Most similar at Yale University

Same institution · by research overlap

Others in their field

Top investigators on “Cells

Research focus

CellsSignal TransductionProteinsBaseFluorescenceMolecularScreeningNeuronsSensorMeasurementSiteBiosensorGreen Fluorescent ProteinsPrototypeResponseCell TypeDrug DiscoveryMontanaImageReaderComplexBrainLifePharmaceutical Preparations

Grant awards (36)

Fluorescent Biosensors for measuring the signaling kinetics of GPCR ligands that activate G12/13 pathways.$364,367
R43 · FY2025 · CA · contact PI
Live Cell Fluorescent Assays for SARS-CoV-2 protease activity and COVID-19 Drug Discovery$300,000
R44 · FY2023 · AI
An optimized screening platform for identifying and quantifying biased agonists as drugs for the treatment of Opioid Use Disorder$315,386
R44 · FY2022 · DA
Live Cell Fluorescent Assays for SARS-CoV-2 protease activity and COVID-19 Drug Discovery$300,000
R44 · FY2022 · AI
An optimized screening platform for identifying and quantifying biased agonists as drugs for the treatment of Opioid Use Disorder$482,109
R44 · FY2021 · DA
A robust assay for detecting agonist bias in living cells.$600,181
R44 · FY2020 · GM
A robust assay for detecting agonist bias in living cells.$634,836
R44 · FY2019 · GM
An optimized screening platform for identifying and quantifying biased agonists as drugs for the treatment of Opioid Use Disorder$221,097
R44 · FY2019 · DA
I-Corps Proposal for Commercialization of Live Cell Assays to Identify and Interrogate Stressed Neurons in Models of Neurodegenerative Disease$55,000
R43 · FY2019 · NS
Development of technologies to advance fast and accurate tools for measuring fluorescence in living cells, with emphasis on developing assays optimized for screening in neuronal cells and brain tissue$210,309
R44 · FY2018 · NS
Live Cell Assays to Identify and Interrogate Stressed Neurons in Models of Neurodegenerative Disease.$195,833
R43 · FY2018 · NS
Northern Lights collaboration for better 2-photon probes$644,649
U01 · FY2017 · NS
Development of technologies to advance fast and accurate tools for measuring fluorescence in living cells, with emphasis on developing assays optimized for screening in neuronal cells and brain tissue$227,000
R44 · FY2017 · NS
A robust assay for detecting agonist bias in living cells.$193,000
R43 · FY2017 · GM
Northern Lights collaboration for better 2-photon probes$718,812
U01 · FY2016 · NS
Genetically-Encoded Voltage Probe Development$551,553
R01 · FY2016 · NS
Northern Lights collaboration for better 2-photon probes$676,827
U01 · FY2015 · NS
Fast and Accurate Tools for Measuring Fluorescence in Living Cells$582,394
R44 · FY2015 · NS
Genetically-Encoded Voltage Probe Development$551,555
R01 · FY2015 · NS
Genetically-Encoded Voltage Probe Development$598,640
R01 · FY2014 · NS
Fast and Accurate Tools for Measuring Fluorescence in Living Cells$585,457
R44 · FY2014 · NS
Genetically-Encoded Voltage Probe Development$604,918
R01 · FY2013 · NS
Fast and Accurate Tools for Measuring Fluorescence in Living Cells$348,182
R43 · FY2011 · MH
A New Modular Tool Set for Live Imaging and Manipulating the Nervous System$105,046
R41 · FY2009 · NS · contact PI
A New Modular Tool Set for Live Imaging and Manipulating the Nervous System$36,668
R41 · FY2009 · NS · contact PI
A New Modular Tool Set for Live Imaging and Manipulating the Nervous System$105,046
R41 · FY2008 · NS · contact PI
Splitting GFP to look at signaling proteins$174,605
R21 · FY2007 · NS · contact PI
Splitting GFP to look at signaling proteins$159,188
R21 · FY2006 · NS · contact PI
Building libraries of GFP-tagged neuronal proteins$168,031
R21 · FY2004 · NS
Building libraries of GFP-tagged neuronal proteins$194,156
R21 · FY2003 · NS
Red/Green Cre recombinase reporter for retina studies$163,500
R03 · FY2002 · EY
VISUAL SCIENCES TRAINING GRANT$155,376
T32 · FY2002 · EY
CORE--IMAGING$0
P30 · FY2002 · EY
TRANSMITTER/RECEPTOR SPECIFIC CIRCUITRY IN THE RETINA$300,092
R01 · FY2001 · EY
VISUAL SCIENCES TRAINING GRANT$151,112
T32 · FY2001 · EY
TRANSMITTER/RECEPTOR SPECIFIC CIRCUITRY IN THE RETINA$291,351
R01 · FY2000 · EY