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Kevan M. Shokat
University Of California San Francisco
$21,480,540
Attributed
$26,978,579
Total exposure
28
Grants
21
Lead (contact PI)
Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.
Funding over time
peak $6.4M · FY2005–25$10M$7.5M$5M$2.5M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25
Funding mix
By agency
NIH$26,978,579 · 28
By mechanism
R01$14,377,047 · 8
U19$5,450,416 · 1
U01$4,319,252 · 1
U54$2,394,581 · 1
R56$331,075 · 1
P41$106,208 · 16
Top collaborators
- Qi Wen Fan7 shared
- William A Weiss7 shared
- Calvin J Kuo5 shared
- Melanie Maria Ott1 shared
- Bjoern Schwer1 shared
Others in their field
Top investigators on “Phosphotransferases”
- David Heimbrook · Leidos Biomedical Research, Inc.$26,594,235
- Gary L. Johnson · National Jewish Health$21,727,284
- Peter Karl Sorger · Massachusetts Institute Of Technology$20,231,592
- Lewis C Cantley · Beth Israel Deaconess Medical Center$19,866,259
- Richard L Huganir · Johns Hopkins University$18,390,405
- Fulton T Crews · University Of North Carolina Chapel Hill$17,915,277
Research focus
PhosphotransferasesCellsProteinsSignal TransductionProtein KinasePathway InteractionsAffinityMutantLigandsMalignant NeoplasmsEngineeringInhibitor/AntagonistSignal PathwayBindingBaseMass Spectrum AnalysisCell LineLeadMediatingUnited States National Institutes Of HealthPhosphorylationIn VivoSmall MoleculeComplex
Grant awards (63)
Targeted small molecule recruitment to suppress the HIV transcriptionally active reservoir$687,416
R01 · FY2025 · DA
Brain-Restricted Kinase Inhibition with Binary Pharmacology$663,348
R01 · FY2025 · CA
Brain-Restricted Kinase Inhibition with Binary Pharmacology$671,177
R01 · FY2024 · CA
Inhibitors of the G protein GNAS which drives pancreatic tumorigenesis$383,528
R01 · FY2024 · CA · contact PI
Inhibitors of the G protein GNAS which drives pancreatic tumorigenesis$395,637
R01 · FY2023 · CA · contact PI
Targeting Viral RNA Using a Sequence Programmable Small Molecule-Oligonucleotide Conjugate$5,450,416
U19 · FY2022 · AI · contact PI
Improving the efficacy of mTOR inhibition$578,475
R01 · FY2022 · CA
Inhibitors of the G protein GNAS which drives pancreatic tumorigenesis$395,637
R01 · FY2022 · CA · contact PI
Improving the efficacy of mTOR inhibition$590,279
R01 · FY2021 · CA
Inhibitors of the G protein GNAS which drives pancreatic tumorigenesis$403,712
R01 · FY2021 · CA · contact PI
Tissue-specific pharmacology to enhance healthspan$331,075
R56 · FY2021 · AG
Improving the efficacy of mTOR inhibition$588,452
R01 · FY2020 · CA
Inhibitors of the G protein GNAS which drives pancreatic tumorigenesis$418,325
R01 · FY2020 · CA · contact PI
Identifying small molecules with therapeutic effects in RELAFus -driven EPN, mand testing them in preclinical genetically engineered models of EPN$2,394,581
U54 · FY2019 · CA · contact PI
Modeling KRAS-Dependent Synthetic Lethality in Human Colon Organoids$900,713
U01 · FY2019 · CA
Improving the efficacy of mTOR inhibition$568,138
R01 · FY2019 · CA
Modeling KRAS-Dependent Synthetic Lethality in Human Colon Organoids$499,437
U01 · FY2019 · CA
Modeling KRAS-Dependent Synthetic Lethality in Human Colon Organoids$876,328
U01 · FY2018 · CA
Improving the efficacy of mTOR inhibition$583,883
R01 · FY2018 · CA
Drugging the Switch-II Pocket of K-Ras$295,409
R01 · FY2018 · CA · contact PI
Modeling KRAS-Dependent Synthetic Lethality in Human Colon Organoids$1,026,181
U01 · FY2017 · CA
Drugging the Switch-II Pocket of K-Ras$298,452
R01 · FY2017 · CA · contact PI
Modeling KRAS-Dependent Synthetic Lethality in Human Colon Organoids$1,016,593
U01 · FY2016 · CA
Drugging the Switch-II Pocket of K-Ras$301,219
R01 · FY2016 · CA · contact PI
Drugging the Switch-II Pocket of K-Ras$303,735
R01 · FY2015 · CA · contact PI
Drugging the Switch-II Pocket of K-Ras$305,319
R01 · FY2014 · CA · contact PI
A Kinase-Substrate Crosslinker For Mapping Signaling Pathways in Reverse$264,637
R01 · FY2012 · EB · contact PI
A Kinase-Substrate Crosslinker For Mapping Signaling Pathways in Reverse$264,637
R01 · FY2011 · EB · contact PI
IDENTIFICATION OF KINASE SUBSTRATES BY COVALENT CAPTURE OF PHOSPHOPEPTIDES$16,865
P41 · FY2011 · RR · contact PI
DEVELOPMENT OF HIGHLY SELECTIVE PROTEIN AND LIPID KINASE INHIBITORS$2,236
P41 · FY2011 · RR · contact PI
CHEMICAL GENETIC IDENTIFICATION OF DIRECT KINASE SUBSTRATES$33
P41 · FY2011 · RR · contact PI
IDENTIFICATION OF PROTEIN KINASE SUBSTRATES$17
P41 · FY2011 · RR · contact PI
A Kinase-Substrate Crosslinker For Mapping Signaling Pathways in Reverse$275,319
R01 · FY2010 · EB · contact PI
CHEMICAL GENETIC IDENTIFICATION OF DIRECT KINASE SUBSTRATES$5,299
P41 · FY2010 · RR · contact PI
IDENTIFICATION OF KINASE SUBSTRATES BY COVALENT CAPTURE OF PHOSPHOPEPTIDES$3,533
P41 · FY2010 · RR · contact PI
IDENTIFICATION OF PROTEIN KINASE SUBSTRATES$3,533
P41 · FY2010 · RR · contact PI
DEVELOPMENT OF HIGHLY SELECTIVE PROTEIN AND LIPID KINASE INHIBITORS$1,766
P41 · FY2010 · RR · contact PI
A Kinase-Substrate Crosslinker For Mapping Signaling Pathways in Reverse$278,100
R01 · FY2009 · EB · contact PI
IDENTIFICATION OF KINASE SUBSTRATES BY COVALENT CAPTURE OF PHOSPHOPEPTIDES$15,618
P41 · FY2009 · RR · contact PI
CHEMICAL GENETIC IDENTIFICATION OF DIRECT KINASE SUBSTRATES$8,685
P41 · FY2009 · RR · contact PI
DEVELOPMENT OF HIGHLY SELECTIVE PROTEIN AND LIPID KINASE INHIBITORS$2,828
P41 · FY2009 · RR · contact PI
CHEMICAL GENETIC IDENTIFICATION OF DIRECT KINASE SUBSTRATES$13,329
P41 · FY2008 · RR · contact PI
Affinity Isolation of Direct Kinase Substrates$302,885
R01 · FY2007 · EB · contact PI
CHEMICAL GENETIC IDENTIFICATION OF DIRECT KINASE SUBSTRATES$18,125
P41 · FY2007 · RR · contact PI
A Chemical Map of T Cell Signaling$317,795
R01 · FY2006 · AI · contact PI
Affinity Isolation of Direct Kinase Substrates$311,931
R01 · FY2006 · EB · contact PI
Using chemical genetics to investigate mechanisms of anesthetic action$153,583
R01 · FY2006 · EB · contact PI
CHEMICAL GENETIC IDENTIFICATION OF DIRECT KINASE SUBSTRATES$9,994
P41 · FY2006 · RR · contact PI
TYROSINE KINASE PHOSPHORYLATION W/CHEMICAL TAG TO DETERMINE IN VIVO SUBSTRATES$144
P41 · FY2006 · RR · contact PI
Affinity Isolation of Direct Kinase Substrates$378,750
R01 · FY2005 · EB
A Chemical Map of T Cell Signaling$376,200
R01 · FY2005 · AI
TYROSINE KINASE PHOSPHORYLATION W/CHEMICAL TAG TO DETERMINE IN VIVO SUBSTRATES$119
P41 · FY2005 · RR
A Chemical Map of T Cell Signaling$376,200
R01 · FY2004 · AI
Affinity Isolation of Direct Kinase Substrates$353,000
R01 · FY2004 · EB
TYROSINE KINASE PHOSPHORYLATION WITH A CHEMICAL TAG$4,084
P41 · FY2004 · RR
A Chemical Map of T Cell Signaling$354,570
R01 · FY2003 · AI
Affinity Isolation of Direct Kinase Substrates$352,667
R01 · FY2003 · EB
A Chemical Map of T Cell Signaling$343,758
R01 · FY2002 · AI
ENGINEERING ORTHOGONAL PROTEIN KINASE AND NUCLEOTIDES$318,680
R01 · FY2002 · CA
ENGINEERING ORTHOGONAL PROTEIN KINASE AND NUCLEOTIDES$309,783
R01 · FY2001 · CA
SPECIFIC INHIBITOR OF LCK TO PROBE T CELL SIGNALING$157,934
R01 · FY2001 · AI
ENGINEERING ORTHOGONAL PROTEIN KINASE AND NUCLEOTIDES$301,143
R01 · FY2000 · CA
SPECIFIC INHIBITOR OF LCK TO PROBE T CELL SIGNALING$153,334
R01 · FY2000 · AI