← Leaderboards
William F Degrado
University Of Pennsylvania
$44,950,833
Attributed
$51,331,229
Total exposure
50
Grants
36
Lead (contact PI)
Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.
Funding over time
peak $4.9M · FY2005–25$5M$3.8M$2.5M$1.3M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25
Funding mix
By agency
NIH$51,331,229 · 50
By mechanism
R01$16,176,970 · 7
U01$7,473,439 · 1
R35$6,480,313 · 1
UH3$4,519,111 · 1
P01$4,084,466 · 5
U19$3,846,686 · 1
Top collaborators
- Dean Sheppard5 shared
- Shan Lu4 shared
- Jose Nieva4 shared
- Jamie K Scott4 shared
- Carlo L Condello1 shared
Most similar at University Of Pennsylvania
Same institution · by research overlap
- Mortimer Poncz$48,626,684
- Peter S Klein$17,059,335
- A. Joshua Wand$18,137,286
- Michael S Marks$18,307,737
- Nirinjini N Naidoo$10,036,000
Others in their field
Top investigators on “Structure”
- David Heimbrook · Leidos Biomedical Research, Inc.$475,333,582
- Barton F Haynes · Duke University$444,977,767
- Lawrence Corey · Fred Hutchinson Cancer Center$334,646,086
- Gary D Acton · University Of California-Davis$320,373,312
- Mitchell J Malone · Texas A&M Research Foundation$320,373,312
- Michael David Hughes · Harvard University D/B/A Harvard School Of Public Health$315,257,203
Research focus
StructureProteinsDesignMembrane ProteinsPeptidesPharmaceutical PreparationsFundingProtein StructureMembraneMutantProtein FoldingIn VivoEnvironmentBinding (Molecular Function)AmantadineSmall MoleculeComplexTransmembrane DomainMolecular ConformationProtonsBaseCellsIn VitroDrug Design
Grant awards (123)
Deciphering the relationship between structure, dynamics and function in helical bundle proteins$666,046
R35 · FY2025 · GM · contact PI
Deciphering the relationship between structure, dynamics and function in helical bundle proteins$666,047
R35 · FY2024 · GM · contact PI
Project 2: Conformation and propagation of misfolded forms of tau and Abeta$403,750
P01 · FY2024 · AG · contact PI
Deciphering the relationship between structure, dynamics and function in helical bundle proteins$718,047
R35 · FY2023 · GM · contact PI
Project 2: Conformation and propagation of misfolded forms of tau and Abeta$403,750
P01 · FY2023 · AG · contact PI
Targeting Viroporins and Coronavirus M Protein$3,846,686
U19 · FY2022 · AI · contact PI
Deciphering the relationship between structure, dynamics and function in helical bundle proteins$666,047
R35 · FY2022 · GM · contact PI
Project 2: Conformation and propagation of misfolded forms of tau and Abeta$403,750
P01 · FY2022 · AG · contact PI
Deciphering the relationship between structure, dynamics and function in helical bundle proteins$711,887
R35 · FY2021 · GM · contact PI
Project 2: Conformation and propagation of misfolded forms of tau and Abeta$403,750
P01 · FY2021 · AG · contact PI
Deciphering the relationship between structure, dynamics and function in helical bundle proteins$711,887
R35 · FY2020 · GM · contact PI
Project 2: Conformation and propagation of misfolded forms of tau and Abeta$403,543
P01 · FY2020 · AG · contact PI
Deciphering the relationship between structure, dynamics and function in helical bundle proteins$711,887
R35 · FY2019 · GM · contact PI
Project 3: Assembly and structures of Abeta peptides.$332,751
P01 · FY2019 · AG · contact PI
Relationships between conformational strains of tau and amyloid-beta, TREM2 and APOE variants, and phenotypic variations of Alzheimer's Disease$1,996,800
RF1 · FY2018 · AG
Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.$1,517,775
UH3 · FY2018 · HL
Deciphering the relationship between structure, dynamics and function in helical bundle proteins$880,940
R35 · FY2018 · GM · contact PI
Project 3: Assembly and structures of Abeta peptides.$332,713
P01 · FY2018 · AG · contact PI
Deciphering the relationship between structure, dynamics and function in helical bundle proteins$96,117
R35 · FY2018 · GM · contact PI
Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.$1,555,009
UH3 · FY2017 · HL
Deciphering the relationship between structure, dynamics and function in helical bundle proteins$651,408
R35 · FY2017 · GM · contact PI
Project 3: Assembly and structures of Abeta peptides.$327,752
P01 · FY2017 · AG · contact PI
Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.$1,446,327
UH3 · FY2016 · HL
De Novo Design of Alpha-Helical Bundles$388,325
R01 · FY2016 · GM · contact PI
Structure of M2 Proton Channel from Influenza A Virus$362,835
R01 · FY2016 · GM · contact PI
Project 3: Assembly and structures of Abeta peptides.$297,997
P01 · FY2016 · AG · contact PI
Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.$1,025,193
UH2 · FY2015 · HL
Vaccines that Replicate the Neutralization-Competent Structure of the gp41 MPER$693,593
R01 · FY2015 · AI
De Novo Design of Alpha-Helical Bundles$388,325
R01 · FY2015 · GM · contact PI
Structure of M2 Proton Channel from Influenza A Virus$362,648
R01 · FY2015 · GM · contact PI
Project 3: Assembly and structures of Abeta peptides.$298,852
P01 · FY2015 · AG · contact PI
Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.$1,137,523
UH2 · FY2014 · HL
Vaccines that Replicate the Neutralization-Competent Structure of the gp41 MPER$678,372
R01 · FY2014 · AI
De Novo Design of Alpha-Helical Bundles$387,100
R01 · FY2014 · GM · contact PI
Structure of M2 Proton Channel from Influenza A Virus$361,344
R01 · FY2014 · GM · contact PI
Vaccines that Replicate the Neutralization-Competent Structure of the gp41 MPER$648,324
R01 · FY2013 · AI
Design and mechanistic studies of mimics of antimicrobial peptides$572,959
R56 · FY2013 · AI · contact PI
De novo design of alpha-helical bundles$365,314
R37 · FY2013 · GM · contact PI
Structure of M2 Proton Channel from Influenza A Virus$359,480
R01 · FY2013 · GM · contact PI
Development of drugs that target the M2 proton channel from the influenza A Virus$1,408,915
U01 · FY2012 · AI · contact PI
Vaccines that Replicate the Neutralization-Competent Structure of the gp41 MPER$701,154
R01 · FY2012 · AI
Design and mechanistic studies of mimics of antimicrobial peptides$602,678
R01 · FY2012 · AI · contact PI
De novo design of alpha-helical bundles$378,564
R37 · FY2012 · GM · contact PI
Development of drugs that target the M2 proton channel from the influenza A Virus$1,396,058
U01 · FY2011 · AI · contact PI
Design and mechanistic studies of mimics of antimicrobial peptides$463,490
R01 · FY2011 · AI · contact PI
De novo design of alpha-helical bundles$288,519
R37 · FY2011 · GM · contact PI
Design and mechanistic studies of mimics of antimicrobial peptides$140,113
R01 · FY2011 · AI · contact PI
De novo design of alpha-helical bundles$86,373
R37 · FY2011 · GM · contact PI
2D IR OF TRANS-MEMBRANE HELIX STRUCTURES$71,546
P41 · FY2011 · RR · contact PI
2D IR SPECTROSCOPY OF COLLAGEN DOMAIN STRUCTURES$14,958
P41 · FY2011 · RR · contact PI
TRANSMEMBRANE DOMAIN OF INFLUENZA A M2 PROTON CHANNEL$5,487
P41 · FY2011 · RR · contact PI
DEVELPMENT OF DRUGS THAT TARGET THE M2 PROTON CHANNEL$4,039
P41 · FY2011 · RR · contact PI
Development of drugs that target the M2 proton channel from the influenza A Virus$1,623,145
U01 · FY2010 · AI · contact PI
Design and mechanistic studies of mimics of antimicrobial peptides$612,144
R01 · FY2010 · AI · contact PI
De novo design of alpha-helical bundles$389,257
R37 · FY2010 · GM · contact PI
2D IR OF TRANS-MEMBRANE HELIX STRUCTURES$41,547
P41 · FY2010 · RR · contact PI
2D IR SPECTROSCOPY OF COLLAGEN DOMAIN STRUCTURES$19,114
P41 · FY2010 · RR · contact PI
Development of drugs that target the M2 proton channel from the influenza A Virus$1,535,177
U01 · FY2009 · AI · contact PI
Design and mechanistic studies of mimics of antimicrobial peptides$603,362
R01 · FY2009 · AI · contact PI
De novo design of alpha-helical bundles$391,197
R37 · FY2009 · GM · contact PI
Bioorganic models for transmembrane proteins$278,210
R01 · FY2009 · GM · contact PI
Development of drugs that target the M2 proton channel from the influenza A Virus$80,144
U01 · FY2009 · AI · contact PI
2D IR OF TRANS-MEMBRANE HELIX STRUCTURES$47,931
P41 · FY2009 · RR · contact PI
TIME RESOLVED STUDIES OF HELIX COIL TRANSITION IN SMALL PEPTIDES$9,586
P41 · FY2009 · RR · contact PI
PROBING THE PROTON GATING DYNAMICS OF THE INFLUENZA VIRUS M2 CHANNEL USING FCS$9,586
P41 · FY2009 · RR · contact PI
Development of drugs that target the M2 proton channel from the influenza A Virus$1,430,000
U01 · FY2008 · AI · contact PI
Design and mechanistic studies of mimics of antimicrobial peptides$601,549
R01 · FY2008 · AI · contact PI
Structure of M2 proton channel from influenza A Virus$353,082
R01 · FY2008 · GM · contact PI
De novo design of alpha-helical bundles$320,392
R37 · FY2008 · GM · contact PI
Bioorganic models for transmembrane proteins$278,526
R01 · FY2008 · GM · contact PI
2D IR OF TRANS-MEMBRANE HELIX STRUCTURES$30,990
P41 · FY2008 · RR · contact PI
TIME RESOLVED STUDIES OF HELIX COIL TRANSITION IN SMALL PEPTIDES$10,328
P41 · FY2008 · RR · contact PI
DESIGN OF BIOLOGICALLY ACTIVE NOVEL PROTEINS$473
P41 · FY2008 · RR · contact PI
Structure of M2 proton channel from influenza A Virus$353,259
R01 · FY2007 · GM · contact PI
De novo design of alpha-helical bundles$320,691
R37 · FY2007 · GM · contact PI
Bioorganic models for transmembrane proteins$278,694
R01 · FY2007 · GM · contact PI
Fast Conformational Relaxation in Model Peptides$115,865
P01 · FY2007 · GM · contact PI
2D IR OF TRANS-MEMBRANE STRUCTURES$35,726
P41 · FY2007 · RR · contact PI
TIME RESOLVED IR STUDIES OF HELIX COIL TRANSITION IN SMALL PEPTIDES$17,465
P41 · FY2007 · RR · contact PI
USING NITRILE-DERIVATIZED AMINO ACIDS AS INFRARED PROBES OF LOCAL ENVIRONMENT$1,588
P41 · FY2007 · RR · contact PI
DESIGN OF BIOLOGICALLY ACTIVE NOVEL PROTEINS$314
P41 · FY2007 · RR · contact PI
Structure of M2 proton channel from influenza A Virus$363,987
R01 · FY2006 · GM · contact PI
De novo design of alpha-helical bundles$330,567
R37 · FY2006 · GM · contact PI
Bioorganic models for transmembrane proteins$286,610
R01 · FY2006 · GM · contact PI
Fast Conformational Relaxation in Model Peptides$72,902
P01 · FY2006 · GM · contact PI
2D IR OF MEMBRANE PROTEINS$16,934
P41 · FY2006 · RR · contact PI
DYNAMICS & STRUCTURE OF INDIVIDUAL CALMODULIN PEPTIDE COMPLEX$13,547
P41 · FY2006 · RR · contact PI
ASSOCIATION AND DISSOCIATION DYNAMICS OF TRANSMEMBRANE HELICES$13,547
P41 · FY2006 · RR · contact PI
2D IR OF ISOTOPE HEPTAPROLINE PEPTIDE$10,160
P41 · FY2006 · RR · contact PI
TIME RESOLVED IR STUDIES OF HELIX COIL TRANSITION IN SMALL PEPTIDES$3,387
P41 · FY2006 · RR · contact PI
USING NITRILE-DERIVATIZED AMINO ACIDS AS INFRARED PROBES OF LOCAL ENVIRONMENT$2,709
P41 · FY2006 · RR · contact PI
STRUCTURE PREDICTION OF MEMBRANE PROTEINS$1,012
P41 · FY2006 · RR · contact PI
Proteomics to Biomimetic Polymers: Engineering Principle$593,731
R01 · FY2005 · EB
Structure of M2 proton channel from influenza A Virus$378,815
R01 · FY2005 · GM
De novo design of alpha-helical bundles$342,124
R37 · FY2005 · GM
Fast Conformational Relaxation in Model Peptides$70,778
P01 · FY2005 · GM
2D IR OF MEMBRANE PROTEINS$13,469
P41 · FY2005 · RR
ASSOCIATION AND DISSOCIATION DYNAMICS OF TRANSMEMBRANE HELICES$13,469
P41 · FY2005 · RR
DYNAMICS &STRUCTURE OF INDIVIDUAL CALMODULIN PEPTIDE COMPLEX$13,469
P41 · FY2005 · RR
2D IR OF ISOTOPE HEPTAPROLINE PEPTIDE$10,102
P41 · FY2005 · RR
TIME RESOLVED IR STUDIES OF HELIX COIL TRANSITION IN SMALL PEPTIDES$3,367
P41 · FY2005 · RR
USING NITRILE-DERIVATIZED AMINO ACIDS AS INFRARED PROBES OF LOCAL ENVIRONMENT$2,694
P41 · FY2005 · RR
STRUCTURE PREDICTION OF MEMBRANE PROTEINS$1,028
P41 · FY2005 · RR
Proteomics to Biomimetic Polymers: Engineering Principle$613,221
R01 · FY2004 · EB
De novo design of alpha-helical bundles$342,315
R37 · FY2004 · GM
Structure of M2 proton channel from influenza A Virus$332,850
R01 · FY2004 · GM
Fast Conformational Relaxation in Model Peptides$68,716
P01 · FY2004 · GM
DYNAMICS &STRUCTURE OF INDIVIDUAL CALMODULIN PEPTIDE COMPLEX$13,077
P41 · FY2004 · RR
2D IR OF ISOTOPE HEPTAPROLINE PEPTIDE$6,538
P41 · FY2004 · RR
TIME RESOLVED IR STUDIES OF HELIX COIL TRANSITION IN SMALL PEPTIDES$3,269
P41 · FY2004 · RR
Proteomics to Biomimetic Polymers: Engineering Principle$602,440
R01 · FY2003 · EB
Structure of M2 proton channel from influenza A Virus$332,850
R01 · FY2003 · GM
DE NOVO DESIGN OF ALPHA HELICAL BUNDLES$314,960
R01 · FY2003 · GM
Proteomics to Biomimetic Polymers: Engineering Principle$635,306
R01 · FY2002 · GM
Structure of M2 proton channel from influenza A Virus$332,850
R01 · FY2002 · GM
DE NOVO DESIGN OF ALPHA HELICAL BUNDLES$315,019
R01 · FY2002 · GM
FAST CONFORMATIONAL RELAXATION IN MODEL PEPTIDES$0
P01 · FY2002 · GM
Structure of M2 proton channel from influenza A Virus$320,565
R01 · FY2001 · GM
DE NOVO DESIGN OF ALPHA HELICAL BUNDLES$303,611
R01 · FY2001 · GM
FAST CONFORMATIONAL RELAXATION IN MODEL PEPTIDES$0
P01 · FY2001 · GM
DE NOVO DESIGN OF ALPHA HELICAL BUNDLES$298,083
R01 · FY2000 · GM
BIO-ORGANIC MODELS FOR ION CHANNEL PROTEINS$255,465
R01 · FY2000 · GM
FAST CONFORMATIONAL RELAXATION IN MODEL PEPTIDES$147,597
P01 · FY2000 · GM