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Hidde L Ploegh

Boston Children'S Hospital

Google Scholar ↗PubMed ↗ORCID ↗
$43,368,874
Attributed
$43,368,874
Total exposure
21
Grants
15
Lead (contact PI)

Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants. They are the sole PI on all grants (the two match).

Funding over time

peak $2.9M · FY2005–24
$5M$3.8M$2.5M$1.3M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24

Funding mix

By agency

NIH$43,368,874 · 21

By mechanism

R01$22,558,338 · 9
DP1$11,865,450 · 2
R37$4,566,977 · 1
R21$2,060,663 · 4
T32$1,862,900 · 2
P01$451,211 · 2

Top collaborators

No co-investigators on record.

Others in their field

Top investigators on “Cells”

Research focus

CellsProteinsBaseAntibodiesAntigen PresentationAntigensReactionInterestIn VivoSpecificityEnzymesPeptidesImmune ResponseIn VitroLaboratory MouseSortaseModificationSiteGeneticUbiquitinPathway InteractionsPropertyReceptorResponse

Grant awards (101)

Non-invasive imaging of the anti-tumor immune response$558,258
R01 · FY2024 · CA · contact PI
Imposing order on the family of ubiquitin-conjugating (E2) enzymes through intracellular perturbation with nanobodies$1,239,000
DP1 · FY2023 · AI · contact PI
Non-invasive imaging of the anti-tumor immune response$575,887
R01 · FY2023 · CA · contact PI
Imposing order on the family of ubiquitin-conjugating (E2) enzymes through intracellular perturbation with nanobodies$1,239,000
DP1 · FY2022 · AI · contact PI
Non-invasive imaging of the anti-tumor immune response$575,887
R01 · FY2022 · CA · contact PI
Imposing order on the family of ubiquitin-conjugating (E2) enzymes through intracellular perturbation with nanobodies$1,239,000
DP1 · FY2021 · AI · contact PI
Non-invasive imaging of the anti-tumor immune response$606,892
R01 · FY2021 · CA · contact PI
Imposing order on the family of ubiquitin-conjugating (E2) enzymes through intracellular perturbation with nanobodies$442,500
DP1 · FY2021 · AI · contact PI
Imposing order on the family of ubiquitin-conjugating (E2) enzymes through intracellular perturbation with nanobodies$1,239,000
DP1 · FY2020 · AI · contact PI
A nanobody-based vaccine strategy to combat CoVID-19$442,500
DP1 · FY2020 · AI · contact PI
Imposing order on the family of ubiquitin-conjugating (E2) enzymes through intracellular perturbation with nanobodies$1,239,000
DP1 · FY2019 · AI · contact PI
Sortase-mediated protein engineering for the study of host-pathogen interactions$442,500
R01 · FY2019 · AI · contact PI
Sortase-mediated protein engineering for the study of host-pathogen interactions$442,500
R01 · FY2018 · AI · contact PI
Sortase-mediated protein engineering for the study of host-pathogen interactions$442,500
R01 · FY2017 · AI · contact PI
A new strategy to disrupt protein-protein interactions in eukaryotic cells.$592,950
DP1 · FY2016 · GM · contact PI
Sortase-mediated protein engineering for the study of host-pathogen interactions$388,050
R01 · FY2016 · AI · contact PI
A new strategy to disrupt protein-protein interactions in eukaryotic cells.$321,750
DP1 · FY2016 · GM · contact PI
Non-invasive imaging of the immune response based on the use of isotopically labeled single domain antibody fragments$243,750
R21 · FY2016 · AI · contact PI
Sortase-mediated protein engineering for the study of host-pathogen interactions$1,770
R01 · FY2016 · AI · contact PI
A new strategy to disrupt protein-protein interactions in eukaryotic cells.$975,000
DP1 · FY2015 · GM · contact PI
Sortase-mediated protein engineering for the study of host-pathogen interactions$390,000
R01 · FY2015 · AI · contact PI
Endosomal TLRs and their accessory proteins: cell biology and biochemistry$370,500
R01 · FY2015 · GM · contact PI
Non-invasive imaging of the immune response based on the use of isotopically labeled single domain antibody fragments$292,500
R21 · FY2015 · AI · contact PI
Sortase-mediated installation of recognition modules on T cells for redirected ki$212,063
R21 · FY2015 · CA · contact PI
A new strategy to disrupt protein-protein interactions in eukaryotic cells.$975,000
DP1 · FY2014 · GM · contact PI
Sortase-mediated protein engineering for the study of host-pathogen interactions$482,625
R01 · FY2014 · AI · contact PI
Endosomal TLRs and their accessory proteins: cell biology and biochemistry$370,500
R01 · FY2014 · GM · contact PI
Sortase-mediated installation of recognition modules on T cells for redirected ki$254,475
R21 · FY2014 · CA · contact PI
A new strategy to disrupt protein-protein interactions in eukaryotic cells.$945,750
DP1 · FY2013 · GM · contact PI
Sortase-mediated protein engineering for the study of host-pathogen interactions$453,668
R01 · FY2013 · AI · contact PI
Endosomal TLRs and their accessory proteins: cell biology and biochemistry$357,533
R01 · FY2013 · GM · contact PI
Enzymatic modification of anti-DEC205 to manipulate its immunogenic properties$229,125
R21 · FY2013 · AI · contact PI
A new strategy to disrupt protein-protein interactions in eukaryotic cells.$975,000
DP1 · FY2012 · GM · contact PI
Assembly of MHC Class I Molecules in Vitro and in Vivo$810,147
R01 · FY2012 · AI · contact PI
Sortase-mediated protein engineering for the study of host-pathogen interactions$482,625
R01 · FY2012 · AI · contact PI
Endosomal TLRs and their accessory proteins: cell biology and biochemistry$370,500
R01 · FY2012 · GM · contact PI
Enzymatic modification of anti-DEC205 to manipulate its immunogenic properties$292,500
R21 · FY2012 · AI · contact PI
Assembly of MHC Class I Molecules in Vitro and in Vivo$807,165
R01 · FY2011 · AI · contact PI
Sortase-mediated protein engineering for the study of host-pathogen interactions$482,625
R01 · FY2011 · AI · contact PI
Chemical approaches towards the study deubiquitinating enzymes$391,796
R01 · FY2011 · GM · contact PI
UBIQUITIN C-TERMINAL HYDROLASE L3 COMPLEX WITH UBIQUITIN-BASED SUICIDE SUBSTRATE$3,335
P41 · FY2011 · RR · contact PI
Assembly of MHC Class I Molecules in Vitro and in Vivo$800,339
R01 · FY2010 · AI · contact PI
Sortase-mediated protein engineering for the study of host-pathogen interactions$487,500
R01 · FY2010 · AI · contact PI
Chemical approaches towards the study deubiquitinating enzymes$395,753
R01 · FY2010 · GM · contact PI
Assembly of MHC Class I Molecules in Vitro and in Vivo$787,431
R01 · FY2009 · AI · contact PI
Chemical approaches towards the study deubiquitinating enzymes$399,750
R01 · FY2009 · GM · contact PI
Transduction of cells with transcription factors to achieve nuclear reprogramming$292,500
R21 · FY2009 · EB · contact PI
Assembly of MHC Class I Molecules in Vitro and in Vivo$775,905
R01 · FY2008 · AI · contact PI
Assembly and Trafficking of MHC Class II Molecules$495,308
R01 · FY2008 · AI · contact PI
Chemical approaches towards the study deubiquitinating enzymes$399,750
R01 · FY2008 · GM · contact PI
Transduction of cells with transcription factors to achieve nuclear reprogramming$243,750
R21 · FY2008 · EB · contact PI
Assembly of MHC Class I molecules in vitro and in vivo$694,940
R37 · FY2007 · AI · contact PI
Assembly and Trafficking of MHC Class II Molecules$492,447
R01 · FY2007 · AI · contact PI
VIRAL EVASION STRATEGIES: ANALYSIS OF HERPES VIRUSES HSV, VZV AND HHV-6-7$369,790
R01 · FY2007 · AI · contact PI
Assembly of MHC Class I molecules in vitro and in vivo$695,533
R37 · FY2006 · AI · contact PI
Assembly and Trafficking of MHC Class II Molecules$494,699
R01 · FY2006 · AI · contact PI
VIRAL EVASION STRATEGIES: ANALYSIS OF HERPES VIRUSES HSV, VZV AND HHV-6-7$380,835
R01 · FY2006 · AI · contact PI
Assembly and Trafficking of MHC Class II Molecules$397,452
R01 · FY2005 · AI
Assembly of MHC Class I molecules in vitro and in vivo$368,547
R37 · FY2005 · AI
Assembly of MHC Class I molecules in vitro and in vivo$257,564
R37 · FY2005 · AI
VIRAL EVASION STRATEGIES: ANALYSIS OF HERPES VIRUSES HSV, VZV AND HHV-6-7$242,385
R01 · FY2005 · AI
VIRAL EVASION STRATEGIES: ANALYSIS OF HERPES VIRUSES HSV, VZV AND HHV-6-7$111,150
R01 · FY2005 · AI
Assembly and Trafficking of MHC Class II Molecules$36,972
R01 · FY2005 · AI
Assembly of MHC Class I molecules in vitro and in vivo$585,814
R37 · FY2004 · AI
Assembly and Trafficking of MHC Class II Molecules$430,521
R01 · FY2004 · AI
VIRAL EVASION STRATEGIES: ANALYSIS OF HERPES VIRUSES HSV, VZV AND HHV-6-7$338,250
R01 · FY2004 · AI
Degradation of membrane proteins: new chemical probes$301,860
R01 · FY2004 · GM
PHD PROGRAM IN IMMUNOLOGY$246,039
T32 · FY2004 · CA
PHD PROGRAM IN IMMUNOBIOLOGY$176,249
T32 · FY2004 · AI
Assembly of MHC Class I molecules in vitro and in vivo$566,621
R37 · FY2003 · AI
ASSEMBLY AND TRAFFICKING OF MHC CLASS II MOLECULES$424,833
R01 · FY2003 · AI
Viral evasion strategies: analysis of herpes viruses$336,000
R01 · FY2003 · AI
Degradation of membrane proteins: new chemical probes$301,860
R01 · FY2003 · GM
HLA-G AND EQUIVALENT AND FETO-MATERNAL INTERACTION$301,000
R01 · FY2003 · AI
PHD PROGRAM IN IMMUNOLOGY$240,400
T32 · FY2003 · CA
PHD PROGRAM IN IMMUNOBIOLOGY$133,517
T32 · FY2003 · AI
ASSEMBLY OF MHC CLASS I MOLECULES IN VITRO AND IN VIVO$477,964
R37 · FY2002 · AI
ASSEMBLY AND TRAFFICKING OF MHC CLASS II MOLECULES$414,095
R01 · FY2002 · AI
Degradation of membrane proteins: new chemical probes$301,860
R01 · FY2002 · GM
HLA-G AND EQUIVALENT AND FETO-MATERNAL INTERACTION$249,900
R01 · FY2002 · AI
PHD PROGRAM IN IMMUNOLOGY$221,326
T32 · FY2002 · CA
CELL BIOLOGY OF HEAT SHOCK PROTEIN MEDIATED IMMUNIZATION$200,853
R01 · FY2002 · AI
PHD PROGRAM IN IMMUNOBIOLOGY$101,254
T32 · FY2002 · AI
Molecular aspects of antigen presentation in multiple sclerosis$0
P01 · FY2002 · AI
Molecular aspects of antigen presentation in multiple sclerosis$0
P01 · FY2002 · AI
ASSEMBLY OF MHC CLASS I MOLECULES IN VITRO AND IN VIVO$465,869
R37 · FY2001 · AI
ASSEMBLY AND TRAFFICKING OF MHC CLASS II MOLECULES$403,670
R01 · FY2001 · AI
Degradation of membrane proteins: new chemical probes$301,860
R01 · FY2001 · GM
HLA-G AND EQUIVALENT AND FETO-MATERNAL INTERACTION$300,388
R01 · FY2001 · AI
PHD PROGRAM IN IMMUNOLOGY$221,108
T32 · FY2001 · CA
CELL BIOLOGY OF HEAT SHOCK PROTEIN MEDIATED IMMUNIZATION$195,380
R01 · FY2001 · AI
PHD PROGRAM IN IMMUNOBIOLOGY$156,680
T32 · FY2001 · AI
Molecular aspects of antigen presentation in multiple sclerosis$0
P01 · FY2001 · AI
ASSEMBLY OF MHC CLASS I MOLECULES IN VITRO AND IN VIVO$454,125
R37 · FY2000 · AI
ASSEMBLY AND TRAFFICKING OF MHC CLASS II MOLECULES$393,548
R01 · FY2000 · AI
HLA-G AND EQUIVALENT AND FETO-MATERNAL INTERACTION$301,000
R01 · FY2000 · AI
VIRAL EVASION STRATEGIES--ANALYSIS OF THE HERPES VIRUSES HSV,VZV, AND HHV 6 &7$236,368
P01 · FY2000 · AI
PHD PROGRAM IN IMMUNOLOGY$215,946
T32 · FY2000 · CA
Molecular aspects of antigen presentation in multiple sclerosis$214,843
P01 · FY2000 · AI
CELL BIOLOGY OF HEAT SHOCK PROTEIN MEDIATED IMMUNIZATION$190,066
R01 · FY2000 · AI
PHD PROGRAM IN IMMUNOBIOLOGY$150,381
T32 · FY2000 · AI