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Robert Brosh

National Institute On Aging

Google Scholar ↗PubMed ↗ORCID ↗

$0

Attributed

$0

Total exposure

0

Grants

0

Lead (contact PI)

Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.

Funding mix

By agency

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By mechanism

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Top collaborators

No co-investigators on record.

Most similar at National Institute On Aging

Same institution · by research overlap

Others in their field

Top investigators on “Helicase”

Wesley Ian Sundquist · Utah State Higher Education System--University Of Utah$22,436,218
Alice Telesnitsky · University Of Michigan At Ann Arbor$21,681,930
Stephen Charles Kowalczykowski · University Of California At Davis$19,890,095
Timothy M Lohman · Washington University$13,847,591
Smita S Patel · Univ Of Med/Dent Nj-R W Johnson Med Sch$13,510,453
Thomas D Bannister · H. Lee Moffitt Cancer Ctr & Res Inst$13,370,164

Research focus

HelicaseMolecularMutationDna DamageDna StructureDna RepairPathway InteractionsProteinsCellsResponseStructureDna BiosynthesisIn VivoGeneticGenome StabilityPhenotypeBiologicalBiochemicalGenomic InstabilityMalignant NeoplasmsChromosomal StabilityPlayStressPremature Aging Syndrome

Grant awards (100)

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$822,392

ZIA · FY2025 · AG · contact PI

G4 in Aging at Organismal Level$480,229

ZIA · FY2025 · AG · contact PI

Model Genetic Systems to Study DNA Repair$426,203

ZIA · FY2025 · AG · contact PI

Molecular Characterization of the SARS-CoV-2 Helicase and High-Throughput Screening to Identify Small Molecule SARS-CoV-2 Helicase Inhibitors as Anti-Viral Medicines$420,200

ZIA · FY2025 · AG · contact PI

G-quadruplexes (G4) are potential DNA roadblocks that perturb mitochondrial replication machinery and pose a clinically relevant source of mitochondrial DNA mutation and instability$420,200

ZIA · FY2025 · AG · contact PI

Fanconi Anemia Pathway$372,177

ZIA · FY2025 · AG · contact PI

Ribonucleotide Stress and Aging$300,143

ZIA · FY2025 · AG · contact PI

COVID-19 Nsp13 Helicase Analysis: Assessment of Unwinding SARS-CoV-2 Mutagenic RNA Secondary Structures and Pharmacological Modulation in a Preclinical Model$300,143

ZIA · FY2025 · AG · contact PI

Functional Significance of Mutations in Helicase Genes in Patients with Juvenile Dermatomyositis and anti-MDA5 Autoantibodies$300,143

ZIA · FY2025 · AG · contact PI

NIA Inter-Lab Project: Analyses of Age-Related Phenotypes Displayed by RECQL1 Deficiency in a Rodent Model$186,089

ZIA · FY2025 · AG · contact PI

Investigation of Intercalated (I) Motif DNA Structure at Telomeric Cytosine-Rich Strand in Human Cells Genetically Altered for DNA Helicases$174,083

ZIA · FY2025 · AG · contact PI

DDX39a and Cellular Senescence$120,057

ZIA · FY2025 · AG · contact PI

Function of RecQ helicases in genome stability$60,029

ZIA · FY2025 · AG · contact PI

ALZHEIMERS RESEARCH PROJECT: DNA repair dysfunction in neurodegeneration and Alzheimer's Disease$13,248

ZIA · FY2025 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$964,620

ZIA · FY2024 · AG · contact PI

Functional Significance of Mutations in Helicase Genes in Patients with Juvenile Dermatomyositis and anti-MDA5 Autoantibodies$915,332

ZIA · FY2024 · AG · contact PI

Model Genetic Systems to Study DNA Repair$499,912

ZIA · FY2024 · AG · contact PI

Molecular Characterization of the SARS-CoV-2 Helicase and High-Throughput Screening to Identify Small Molecule SARS-CoV-2 Helicase Inhibitors as Anti-Viral Medicines$492,871

ZIA · FY2024 · AG · contact PI

G-quadruplexes (G4) are potential DNA roadblocks that perturb mitochondrial replication machinery and pose a clinically relevant source of mitochondrial DNA mutation and instability$492,871

ZIA · FY2024 · AG · contact PI

Fanconi Anemia Pathway$436,543

ZIA · FY2024 · AG · contact PI

COVID-19 Nsp13 Helicase Analysis: Assessment of Unwinding SARS-CoV-2 Mutagenic RNA Secondary Structures and Pharmacological Modulation in a Preclinical Model$352,051

ZIA · FY2024 · AG · contact PI

NIA Inter-Lab Project: Analyses of Age-Related Phenotypes Displayed by RECQL1 Deficiency in a Rodent Model$218,272

ZIA · FY2024 · AG · contact PI

Investigation of Intercalated (I) Motif DNA Structure at Telomeric Cytosine-Rich Strand in Human Cells Genetically Altered for DNA Helicases$204,190

ZIA · FY2024 · AG · contact PI

Function of RecQ helicases in genome stability$70,410

ZIA · FY2024 · AG · contact PI

ALZHEIMERS RESEARCH PROJECT: DNA repair dysfunction in neurodegeneration and Alzheimer's Disease$18,047

ZIA · FY2024 · AG · contact PI

Functional Significance of Mutations in Helicase Genes in Patients with Juvenile Dermatomyositis and anti-MDA5 Autoantibodies$627,014

ZIA · FY2023 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$387,609

ZIA · FY2023 · AG · contact PI

Model Genetic Systems to Study DNA Repair$347,708

ZIA · FY2023 · AG · contact PI

Molecular Characterization of the SARS-CoV-2 Helicase and High-Throughput Screening to Identify Small Molecule SARS-CoV-2 Helicase Inhibitors as Anti-Viral Medicines$285,006

ZIA · FY2023 · AG · contact PI

G-quadruplexes (G4) are potential DNA roadblocks that perturb mitochondrial replication machinery and pose a clinically relevant source of mitochondrial DNA mutation and instability$228,005

ZIA · FY2023 · AG · contact PI

Fanconi Anemia Pathway$74,102

ZIA · FY2023 · AG · contact PI

COVID-19 Nsp13 Helicase Analysis: Assessment of Unwinding SARS-CoV-2 Mutagenic RNA Secondary Structures and Pharmacological Modulation in a Preclinical Model$57,001

ZIA · FY2023 · AG · contact PI

Investigation of Intercalated (I) Motif DNA Structure at Telomeric Cytosine-Rich Strand in Human Cells Genetically Altered for DNA Helicases$57,001

ZIA · FY2023 · AG · contact PI

Function of RecQ helicases in genome stability$57,001

ZIA · FY2023 · AG · contact PI

DNA repair dysfunction in neurodegeneration and Alzheimer's Disease$44,702

ZIA · FY2023 · AG · contact PI

NIA Inter-Lab Project: Analyses of Age-Related Phenotypes Displayed by RECQL1 Deficiency in a Rodent Model$5,700

ZIA · FY2023 · AG · contact PI

Functional Significance of Mutations in Helicase Genes in Patients with Juvenile Dermatomyositis and anti-MDA5 Autoantibodies$634,883

ZIA · FY2022 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$392,473

ZIA · FY2022 · AG · contact PI

Model Genetic Systems to Study DNA Repair$352,071

ZIA · FY2022 · AG · contact PI

Molecular Characterization of the SARS-CoV-2 Helicase and High-Throughput Screening to Identify Small Molecule SARS-CoV-2 Helicase Inhibitors as Anti-Viral Medicines$288,583

ZIA · FY2022 · AG · contact PI

G-quadruplexes (G4) are potential DNA roadblocks that perturb mitochondrial replication machinery and pose a clinically relevant source of mitochondrial DNA mutation and instability$230,867

ZIA · FY2022 · AG · contact PI

Fanconi Anemia Pathway$75,032

ZIA · FY2022 · AG · contact PI

COVID-19 Nsp13 Helicase Analysis: Assessment of Unwinding SARS-CoV-2 Mutagenic RNA Secondary Structures and Pharmacological Modulation in a Preclinical Model$57,717

ZIA · FY2022 · AG · contact PI

Investigation of Intercalated (I) Motif DNA Structure at Telomeric Cytosine-Rich Strand in Human Cells Genetically Altered for DNA Helicases$57,717

ZIA · FY2022 · AG · contact PI

NIA Inter-Lab Project: Analyses of Age-Related Phenotypes Displayed by RECQL1 Deficiency in a Rodent Model$5,772

ZIA · FY2022 · AG · contact PI

Molecular Characterization of the SARS-CoV-2 Helicase and High-Throughput Screening to Identify Small Molecule SARS-CoV-2 Helicase Inhibitors as Anti-Viral Medicines$735,446

ZIA · FY2021 · AG · contact PI

Functional Significance of Mutations in Helicase Genes in Patients with Juvenile Dermatomyositis and anti-MDA5 Autoantibodies$630,382

ZIA · FY2021 · AG · contact PI

Fanconi Anemia Pathway$215,381

ZIA · FY2021 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$136,583

ZIA · FY2021 · AG · contact PI

Model Genetic Systems to Study DNA Repair$126,076

ZIA · FY2021 · AG · contact PI

G-quadruplexes (G4) are potential DNA roadblocks that perturb mitochondrial replication machinery and pose a clinically relevant source of mitochondrial DNA mutation and instability$110,317

ZIA · FY2021 · AG · contact PI

NIA Inter-Lab Project: Analyses of Age-Related Phenotypes Displayed by RECQL1 Deficiency in a Rodent Model$52,532

ZIA · FY2021 · AG · contact PI

Molecular Characterization of the SARS-CoV-2 Helicase and High-Throughput Screening to Identify Small Molecule SARS-CoV-2 Helicase Inhibitors as Anti-Viral Medicines$30,287

ZIA · FY2020 · AG · contact PI

Functional Significance of Mutations in Helicase Genes in Patients with Juvenile Dermatomyositis and anti-MDA5 Autoantibodies$30,287

ZIA · FY2020 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$27,258

ZIA · FY2020 · AG · contact PI

Model Genetic Systems to Study DNA Repair$24,230

ZIA · FY2020 · AG · contact PI

Fanconi Anemia Pathway$21,201

ZIA · FY2020 · AG · contact PI

G-quadruplexes (G4) are potential DNA roadblocks that perturb mitochondrial replication machinery and pose a clinically relevant source of mitochondrial DNA mutation and instability$3,029

ZIA · FY2020 · AG · contact PI

NIA Inter-Lab Project: Analyses of Age-Related Phenotypes Displayed by RECQL1 Deficiency in a Rodent Model$3,029

ZIA · FY2020 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$359,990

ZIA · FY2019 · AG · contact PI

Model Genetic Systems to Study DNA Repair$348,562

ZIA · FY2019 · AG · contact PI

Fanconi Anemia Pathway$262,850

ZIA · FY2019 · AG · contact PI

G-quadruplexes (G4) are potential DNA roadblocks that perturb mitochondrial replication machinery and pose a clinically relevant source of mitochondrial DNA mutation and instability$28,571

ZIA · FY2019 · AG · contact PI

NIA Inter-Lab Project: Analyses of Age-Related Phenotypes Displayed by RECQL1 Deficiency in a Rodent Model$28,571

ZIA · FY2019 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$360,419

ZIA · FY2018 · AG · contact PI

Model Genetic Systems to Study DNA Repair$348,978

ZIA · FY2018 · AG · contact PI

Fanconi Anemia Pathway$263,163

ZIA · FY2018 · AG · contact PI

NIA Inter-Lab Project: Analyses of Age-Related Phenotypes Displayed by RECQL1 Deficiency in a Rodent Model$28,605

ZIA · FY2018 · AG · contact PI

G-quadruplexes (G4) are potential DNA roadblocks that perturb mitochondrial replication machinery and pose a clinically relevant source of mitochondrial DNA mutation and instability$28,605

ZIA · FY2018 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$772,325

ZIA · FY2017 · AG · contact PI

Fanconi Anemia Pathway$518,484

ZIA · FY2017 · AG · contact PI

Model Genetic Systems to Study DNA Repair$329,453

ZIA · FY2017 · AG · contact PI

NIA Inter-Lab Project: Analyses of Age-Related Phenotypes Displayed by RECQL1 Deficiency in a Rodent Model$27,004

ZIA · FY2017 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$542,336

ZIA · FY2016 · AG · contact PI

Fanconi Anemia Pathway$278,980

ZIA · FY2016 · AG · contact PI

Model Genetic Systems to Study DNA Repair$272,284

ZIA · FY2016 · AG · contact PI

NIA Inter-Lab Project: Analyses of Age-Related Phenotypes Displayed by RECQL1 Deficiency in a Rodent Model$22,318

ZIA · FY2016 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$532,320

ZIA · FY2015 · AG · contact PI

Fanconi Anemia Pathway$263,004

ZIA · FY2015 · AG · contact PI

Model Genetic Systems to Study DNA Repair$256,692

ZIA · FY2015 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$588,952

ZIA · FY2014 · AG · contact PI

Fanconi Anemia Pathway$290,984

ZIA · FY2014 · AG · contact PI

Model Genetic Systems to Study DNA Repair$284,001

ZIA · FY2014 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$579,461

ZIA · FY2013 · AG · contact PI

Fanconi Anemia Pathway$273,943

ZIA · FY2013 · AG · contact PI

Model Genetic Systems to Study DNA Repair$267,369

ZIA · FY2013 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$406,635

ZIA · FY2012 · AG · contact PI

Fanconi Anemia Pathway$301,927

ZIA · FY2012 · AG · contact PI

Model Genetic Systems to Study DNA Repair$294,680

ZIA · FY2012 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$277,268

ZIA · FY2011 · AG · contact PI

Fanconi Anemia Pathway$234,179

ZIA · FY2011 · AG · contact PI

Model Genetic Systems to Study DNA Repair$228,558

ZIA · FY2011 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$234,498

ZIA · FY2010 · AG · contact PI

Fanconi Anemia Pathway$198,056

ZIA · FY2010 · AG · contact PI

Model Genetic Systems to Study DNA Repair$193,302

ZIA · FY2010 · AG · contact PI

Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability$242,057

ZIA · FY2009 · AG · contact PI

Fanconi Anemia Pathway$201,714

ZIA · FY2009 · AG · contact PI

Model Genetic Systems to Study DNA Repair$201,714

ZIA · FY2009 · AG · contact PI

Fanconi Anemia Pathway$189,865

Z01 · FY2008 · AG · contact PI

Model Genetic Systems to Study DNA Repair$182,270

Z01 · FY2008 · AG · contact PI