PRC Project--Butters

$189,014P30FY2011MHNIH

University Of Pittsburgh At Pittsburgh, Pittsburgh PA

Investigators

Linked publications & trials

Paper 39711702 Paper 38187404 Paper 38187403 Paper 37952113 Paper 37378490 Paper 37267732 Paper 37256634 Paper 37212116 Paper 36325158 Paper 35818288 Paper 35393165 Paper 34969584 Paper 34932079 Paper 33406968 Paper 33387385 Paper 33044352 Paper 33001148 Paper 32991792 Paper 32785256 Paper 32749491 Paper 32680764 Paper 32215634 Paper 31916662 Paper 31682328 Paper 31617234 Paper 31214692 Paper 31111114 Paper 31047790 Paper 30886137 Paper 30868641 Paper 30797651 Paper 30795944 Paper 30761967 Paper 30685701 Paper 30358242 Paper 30013927 Paper 29924506 Paper 29659205 Paper 29617064 Paper 29526608 Paper 29416225 Paper 29394305 Paper 29254550 Paper 29170758 Paper 29122145 Paper 29088928 Paper 29069615 Paper 29059360 Paper 29057368 Paper 28975710 Paper 28954595 Paper 28931620 Paper 28914724 Paper 28843842 Paper 28555718 Paper 28410857 Paper 28306157 Paper 28237826 Paper 28161155 Paper 27891528 Paper 27856124 Paper 27793576 Paper 27693188 Paper 27689842 Paper 27654986 Paper 27645461 Paper 27636232 Paper 27618273 Paper 27591916 Paper 27538352 Paper 27524792 Paper 27438687 Paper 27416139 Paper 27364483 Paper 27298114 Paper 27282141 Paper 27276373 Paper 27267633 Paper 27254085 Paper 27245186 Paper 27190081 Paper 27162147 Paper 27122363 Paper 27106884 Paper 27090303 Paper 27067066 Paper 27066730 Paper 26963689 Paper 26894326 Paper 26809601 Paper 26799782 Paper 26782861 Paper 26708830 Paper 26706911 Paper 26552935 Paper 26535508 Paper 26446615 Paper 26432693 Paper 26423182 Paper 26412763

Abstract

Mild cognitive impairment (MCI) is a transitional state between normal cognitive function and dementia. Depression frequently co-occurs with MCI and each increases the risk of developing the other.(192-196) Cognitive loss may act as a stressor (much like any chronic and potentially progressive medical illness), associated with a constellation of psychosocial factors that have been linked to increased depression risk.(197199) Once older adults develop major depression, multiple pathologic mechanisms (i.e., vascular, neurodegenerative, stress hormone toxicity(200-201) likely mediated by neuroinflammation, increase the risk of cognitive decline (in the case of depression risk of progression to dementia is doubled).(202)

View original record on NIH RePORTER →