STRUCTURE OF A SMALL SPHERICAL VIRUS

$7,381R37FY2000AINIH

Purdue University West Lafayette, West Lafayette IN

Investigators

Linked publications & trials

Paper 30787293 Paper 30674888 Paper 30530701 Paper 29674632 Paper 29255015 Paper 27511920 Paper 27185929 Paper 26787879 Paper 26563423 Paper 25982526 Paper 25878099 Paper 25554786 Paper 25240455 Paper 25103897 Paper 25075323 Paper 25003382 Paper 24469789 Paper 24027306 Paper 23926353 Paper 23889891 Paper 23509286 Paper 23221609 Paper 23091035 Paper 23040048 Paper 22948923 Paper 22891297 Paper 22383808 Paper 21909343 Paper 21873222 Paper 21646533 Paper 21636897 Paper 21367911 Paper 21367906 Paper 21068243 Paper 20881044 Paper 20861263 Paper 20702621 Paper 20552732 Paper 20551678 Paper 20007369 Paper 19955311 Paper 19889775 Paper 19541619 Paper 19402750 Paper 19321620 Paper 19027752 Paper 19011098 Paper 18508892 Paper 17850743 Paper 17804498 Paper 17626084 Paper 17420467 Paper 17116403 Paper 16185710 Paper 16004874 Paper 15661151 Paper 15452226 Paper 15331736 Paper 15289612 Paper 12663789 Paper 12119400 Paper 12051899 Paper 11160747 Paper 10618374

Abstract

DESCRIPTION: The applicant proposes to study the structure of a large number of human and animal viruses, virus interactions with receptors, antiviral compounds, and antibodies, as well as assembly intermediates by combination of X-ray crystallography and cryo-electron microscopy. Viruses to be studied include those from the picornavirus family, e.g., rhinovirus, coxsackievirus and poliovirus, and Mengo virus, and from the parvovirus family, e.g. human B19, MVM, porcine, canine and feline parvoviruses. The major focus is to study the interactions of the virus capsid with their receptors and antibodies, and structural changes involved in the process.

View original record on NIH RePORTER →