DETERMINATION OF AGE-RELATED DEFECTS IN CHIKUNGUNYA VIRUS INFECTION

$47,603P51FY2010RRNIH

Oregon Health & Science University, Portland OR

Investigators

Linked publications & trials

Paper 39531811 Paper 37708918 Paper 37499736 Paper 36939178 Paper 36917864 Paper 36907435 Paper 35316218 Paper 34915175 Paper 34540718 Paper 34218053 Paper 33524104 Paper 32637610 Paper 30522845 Paper 30201462 Paper 30139430 Paper 30082858 Paper 29971796 Paper 29520866 Paper 29407362 Paper 29063622 Paper 28936565 Paper 28873045 Paper 28284896 Paper 28154169 Paper 27859771 Paper 27635049 Paper 27357159 Paper 27265023 Paper 27045379 Paper 26957355 Paper 26721679 Paper 26621857 Paper 26472457 Paper 26406934 Paper 26284599 Paper 26223349 Paper 26187412 Paper 26070857 Paper 26069734 Paper 25976012 Paper 25913366 Paper 25612682 Paper 25545382 Paper 25470211 Paper 25376878 Paper 25332397 Paper 25219362 Paper 25209798 Paper 25034695 Paper 25011649 Paper 24959820 Paper 24862904 Paper 24709587 Paper 24681059 Paper 24639226 Paper 24560476 Paper 24448900 Paper 24413616 Paper 24408325 Paper 24390280 Paper 24375078 Paper 24329418 Paper 24324408 Paper 24215535 Paper 24210020 Paper 24202052 Paper 24200973 Paper 24179112 Paper 24174435 Paper 24092271 Paper 24080959 Paper 24077067 Paper 24063855 Paper 24055980 Paper 23959334 Paper 23948905 Paper 23921100 Paper 23908248 Paper 23891857 Paper 23881606 Paper 23816568 Paper 23709130 Paper 23675327 Paper 23651991 Paper 23594602 Paper 23568382 Paper 23559626 Paper 23550738 Paper 23543038 Paper 23482462 Paper 23463525 Paper 23442156 Paper 23439920 Paper 23423613 Paper 23378731 Paper 23357537 Paper 23333375 Paper 23325800 Paper 23279544 Paper 23260193

Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to elucidate the immunological basis of increased susceptibility of aged individuals to Chikungunya virus (CHIKV) infection using a non-human primate (NHP) model. CHIKV, a NIAID Category C Biological Agent, is a re-emerging arbovirus that caused massive recent outbreaks in the Indian Ocean. To date, infections have been limited to Africa and the Indian Ocean Region;however, recent outbreaks in Europe have increased worldwide awareness of this debilitating and potentially lethal viral infection. Importantly, the mosquitoes that transmit CHIKV are now found in much of the Southeastern United States making CHIKV spread possible in the US. While CHIK is not considered to be life threatening, over 200 fatalities were associated with the disease on the French island of Reunion in the Indian Ocean in 2005-6. Additionally, virus-induced arthritis can be extremely debilitating and last for weeks to years in the aged. Severe cases involving infections of the central nervous system have also been described in immune compromised individuals including the elderly. We propose to compare the pathophysiology of CHIKV infection and identify age-related differences in adaptive immunity that underlie increased disease severity in the elderly using a NHP model of CHIKV infection. To date we have performed an initial study to identify the virus strain and dosage that are required for infection of adult Rhesus macaques. We have characterized the immune response and viral load in these animals. We will next infect aged Rhesus macaques.

View original record on NIH RePORTER →