COMPARATIVE STUDIES OF AGING

$54,827P51FY2010RRNIH

Emory University, Atlanta GA

Investigators

Linked publications & trials

Paper 38214558 Paper 37693595 Paper 36114169 Paper 36074577 Paper 35445423 Paper 34855621 Paper 34498433 Paper 34437736 Paper 33910220 Paper 33707771 Paper 33529681 Paper 33463551 Paper 33359631 Paper 33338613 Paper 33137689 Paper 33084571 Paper 32951543 Paper 32905842 Paper 32612608 Paper 32580662 Paper 32569766 Paper 32561559 Paper 32332110 Paper 32250460 Paper 31926168 Paper 31904583 Paper 31898839 Paper 31722194 Paper 31643109 Paper 31455727 Paper 31341049 Paper 31080066 Paper 30910223 Paper 30807811 Paper 30778066 Paper 30718403 Paper 30541829 Paper 30502901 Paper 30486918 Paper 30450384 Paper 30295946 Paper 30237074 Paper 30232277 Paper 30178424 Paper 30021123 Paper 29997216 Paper 29987877 Paper 29983703 Paper 29978933 Paper 29929489 Paper 29928280 Paper 29887142 Paper 29777188 Paper 29752749 Paper 29657070 Paper 29614657 Paper 29510099 Paper 29508924 Paper 29454797 Paper 29386136 Paper 29357021 Paper 29345365 Paper 29158413 Paper 29133346 Paper 29065175 Paper 28926189 Paper 28899729 Paper 28862836 Paper 28842187 Paper 28829774 Paper 28819207 Paper 28648500 Paper 28622613 Paper 28483344 Paper 28483199 Paper 28461219 Paper 28377304 Paper 28369850 Paper 28337120 Paper 28289708 Paper 28269776 Paper 28242325 Paper 28215744 Paper 28159893 Paper 28126752 Paper 28093566 Paper 28051083 Paper 28030956 Paper 28027448 Paper 28025095 Paper 27942478 Paper 27931313 Paper 27928002 Paper 27893962 Paper 27880897 Paper 27870344 Paper 27870343 Paper 27861291 Paper 27851926 Paper 27849172

Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project compares trajectories of cognitive and brain aging in Homo sapiens with the pattern of aging in two closely related primate species, Pan troglodytes and Macaca mulatta. One key element of the project is the construct validity study being carried out at Georgia Institute of Technology under the direction of Dr. Anderson Smith. Approximately 200 normal human subjects have been tested in this study to examine the validity of widely used monkey tasks in assessing performance on specific domains of human cognitive function. This portion of the study has demonstrated that there are indeed age-related changes in humans that negatively affect performance of those tasks developed for the non human primate (NHP). Analyses are now underway to determine whether declines in performance of these tasks correlate with declines in tasks in common use in the studies of human cognitive aging. The NHP studies involve 36 chimpanzees and 24 rhesus monkeys. Each NHP undergoes a behavioral test battery designed to assess specific aspects of cognitive functioning that can be linked to brain regions such as the dorsolateral prefrontal cortex (dlPFC) or the hippocampal formation. In addition, we have recently added a series of tasks for the chimpanzee that have been used in comparative studies of childhood and development in humans and chimpanzees. During the past project year, we have also refined and developed the set of tasks that are to be used with healthy humans, as well as in humans with Mild Cognitive Impairment of the amnestic variety and in patients with Alzheimer's disease. These behavioral studies, as well as complementary in vivo neuroimaging studies, will shed light upon the differences in cognitive and aging processes that foster the human-specific pattern of aging and disease and will therefore inform strategies of therapeutic intervention in the human clinic.

View original record on NIH RePORTER →