STRUCTURAL ANALYSIS OF BOXA RNA IN COMPLEX WITH HOST ELONGATION FACTORS INVOLVED

$346P41FY2010RRNIH

Stanford University, Stanford CA

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Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Transcription antitermination is one of several mechanisms regulating gene expression. Non-processive antitermination, a system best characterized in bacteriophage lambda, involves structural modification of RNA polymerase (RNAP) by a complex of proteins, enabling transcription through downstream factor-dependent termination sites. The antitermination complex consists of phage protein N, N-utilization RNA control sequences (BoxA and BoxB), and at least four host proteins referred to as N-utilization substances (NusA, NusB, NusE, and NusG). Our goal is to use x-ray crystallography to analyze this complex, particularly the specific interactions between BoxA, NusB, and NusE (ribosomal protein S10) as this stable sub-complex is thought to facilitate complex assembly.

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