Targeted induction of true sunless tanning for skin cancer preventation

Massachusetts General Hospital, Boston MA

Investigators

Linked publications & trials

Abstract

DESCRIPTION (provided by applicant): We have discovered drugs capable of inducing skin melanin production without producing DNA damage, like UV radiation. This approach protects against UV induced skin cancers in mice. Here, we will evaluate and identify drugs capable of darkening human skin by use of immunocompromised mice containing normal human skin xenografts as a preclinical humanized-mouse skin model.