Molecular Genetic Approaches in Atherosclerosis Research

$2,540,124P01FY2010HLNIH

University Of California Los Angeles, Los Angeles CA

Investigators

Linked publications & trials

Paper 37178122 Paper 36342933 Paper 36276926 Paper 34995504 Paper 34861179 Paper 34697471 Paper 34543273 Paper 34494556 Paper 34385484 Paper 34354069 Paper 34340684 Paper 34011630 Paper 33948567 Paper 33626882 Paper 33626337 Paper 33594006 Paper 33591957 Paper 33560372 Paper 33553972 Paper 33479282 Paper 33417276 Paper 33221593 Paper 33219609 Paper 32942044 Paper 32915782 Paper 32866618 Paper 32855239 Paper 32791310 Paper 32332754 Paper 32259026 Paper 32161260 Paper 31869344 Paper 31852219 Paper 31834882 Paper 31564431 Paper 31538139 Paper 31399369 Paper 31368839 Paper 31340670 Paper 31220077 Paper 31201301 Paper 31167634 Paper 31070450 Paper 30834892 Paper 30814737 Paper 30813962 Paper 30804008 Paper 30641857 Paper 30639359 Paper 30622162 Paper 30619467 Paper 30617149 Paper 30616562 Paper 30591411 Paper 30538180 Paper 30507612 Paper 30383443 Paper 30343673 Paper 30290150 Paper 30275892 Paper 30272994 Paper 30255820 Paper 30241486 Paper 30169787 Paper 30156571 Paper 30082863 Paper 30026271 Paper 30012703 Paper 29981269 Paper 29950403 Paper 29907965 Paper 29893869 Paper 29844188 Paper 29752291 Paper 29739864 Paper 29719227 Paper 29706320 Paper 29666371 Paper 29637625 Paper 29632379 Paper 29566149 Paper 29548336 Paper 29378845 Paper 29361464 Paper 29339647 Paper 29295820 Paper 29231167 Paper 29186329 Paper 29099096 Paper 28891815 Paper 28772107 Paper 28737175 Paper 28642195 Paper 28636934 Paper 28628359 Paper 28487391 Paper 28475861 Paper 28449094 Paper 28411173 Paper 28407784

Abstract

DESCRIPTION (provided by applicant): Our Program Project is focused on the genetic dissection of metabolic syndrome (MetSyn) in both mouse models and human populations. Our approach is, we believe, unique in its multifaceted and integrative approaches. These include a combination of genetic, genomic, biochemical, physiologic, and bioinformatic analyses. During the current grant cycle, each of the four projects has been highly productive. Project 1 has utilized traditional positional cloning as well as integrative genetics in mice to identify several novel genes affecting adiposity, lipoprotein metabolism, and insulin sensitivity. Project 2 has used linkage and association analysis of human populations to identify a number of novel genes in triglyceride and HDL metabolism. Project 3 has identified and characterized a novel gene controlling the maturation of lipases. Project 4 has carried out detailed molecular studies of the lipin family of proteins, identifying key functions in fat storage and insulin sensitivity. We now propose 4 Projects and 4 Cores. All projects are direct continuations of the present projects, as are the 4 Cores. Project 1 will focus on the integration of mouse and human gene networks for MetSyn and also address the problem of gene-by-environment interactions in MetSyn. Project 2 will further elucidate underlying mechanisms for novel genes identified in human subjects during the present cycle and use both linkage and association in large population samples to further dissect the genetic factors contributing to MetSyn. Project 3 will focus on the biology lipase maturation factor-1, in both mice and humans. Project 4 will examine the role of lipins in adipogenesis and insulin sensitivity and in statin-induced myopathy as well as new genes identified in Project 1. Each of the proposed Projects will interact significantly with each of the other Projects and all of the Cores.

View original record on NIH RePORTER →