Islet Metabolism Core

$212,634P30FY2010DKNIH

University Of California, San Francisco, San Francisco CA

Investigators

Linked publications, trials & patents

Paper 39554105 Paper 39530749 Paper 39489818 Paper 39416108 Paper 39412501 Paper 39399685 Paper 39372944 Paper 39352872 Paper 39225101 Paper 39194236 Paper 39131314 Paper 39131266 Paper 39083602 Paper 39071432 Paper 38979201 Paper 38895482 Paper 38854059 Paper 38811842 Paper 38699348 Paper 38697667 Paper 38574299 Paper 38530369 Paper 38451724 Paper 38430129 Paper 38381789 Paper 38378719 Paper 38374043 Paper 38370809 Paper 38260336 Paper 38238288 Paper 38234734 Paper 38212464 Paper 38181095 Paper 38127070 Paper 38113104 Paper 38102365 Paper 37938561 Paper 37889983 Paper 37878820 Paper 37873143 Paper 37856221 Paper 37831760 Paper 37824329 Paper 37819140 Paper 37745530 Paper 37602717 Paper 37593979 Paper 37547023 Paper 37503095 Paper 37461713 Paper 37333294 Paper 37279920 Paper 37267918 Paper 37147433 Paper 37028427 Paper 36853689 Paper 36822205 Paper 36798286 Paper 36763336 Paper 36615137 Paper 36583937 Paper 36581712 Paper 36351399 Paper 36350984 Paper 36345941 Paper 36288290 Paper 36227993 Paper 36179668 Paper 36142937 Paper 36127421 Paper 36056019 Paper 35951356 Paper 35879364 Paper 35817986 Paper 35784348 Paper 35760778 Paper 35649365 Paper 35623342 Paper 35610647 Paper 35584677 Paper 35584134 Paper 35536884 Paper 35434896 Paper 35427499 Paper 35413104 Paper 35377797 Paper 35355021 Paper 35321880 Paper 35320345 Paper 35318859 Paper 35296537 Paper 35292359 Paper 35269717 Paper 35266954 Paper 35245441 Paper 35236989 Patent 9801911 Patent 9211328 Patent 8637011 Patent 7998481

Abstract

Purpose: The DERC Islet Metabolism Core assists investigators who currently study or have plans to study pancreatic islet cell biology, transplantation and metabolic analysis. Components: 1. Islet Purification. Processing and preparation of human and mouse islets for use in islet transplantation, genomic studies, and cell biology studies. 2. Islet Functional Analysis. Real time biological and biochemical analysis of insulin production and other functional aspects of human and mouse islets to characterize islet activity under different conditions and to assess islet preparation quality for transplantation studies. 3. Mouse Metabolic Analysis. Analysis of the metabolic status of an intact mouse including measurements of fat content, the monitoring of glucose levels in response to exogenous glucose or insulin stimulation and the analysis of oxygen consumption and/or activity. Benefits to DERC Community: These highly specialized capabilities are beyond the reach of almost ail individual laboratories. The Islet Metabolism Core consolidates these unique capabilities and enables the application of these capabilities to research studies by DERC investigators. Standardized protocols ensure reproducibility in analyses conducted on different days. Standardization also enables individual laboratories to compare outcomes. Technology Development: There is an ongoing commitment to continue the prior improvements in islet isolation and analysis. A broader work-up of islet function standard for all preps will be combined with a Core-wide database to assist investigators in making cross-study inferences. Significant improvements in the metabolic analysis of intact mice are expected to represent another major effort in the next DERC cycle.

View original record on NIH RePORTER →