A PHASE I AND PHARMACOKINETIC STUDY OF ORAL 3-AMINOPYRIDINE-2- CARBOXALDEHYDE

$13,914M01FY2009RRNIH

University Of Southern California, Los Angeles CA

Investigators

Linked publications & trials

Paper 38278947 Paper 38190104 Paper 37902424 Paper 37292813 Paper 35291207 Paper 34320286 Paper 34161608 Paper 33479058 Paper 33071178 Paper 32564066 Paper 32064729 Paper 31886931 Paper 31685489 Paper 31594431 Paper 31559418 Paper 31418516 Paper 31338998 Paper 31279092 Paper 31167889 Paper 31131339 Paper 31118516 Paper 31112370 Paper 30997482 Paper 30967435 Paper 30916797 Paper 30900413 Paper 30833373 Paper 30801985 Paper 30734524 Paper 30661481 Paper 29936086 Paper 29896938 Paper 29758564 Paper 29697830 Paper 29614631 Paper 29427697 Paper 29398050 Paper 29246363 Paper 29157731 Paper 28938457 Paper 28865061 Paper 28664624 Paper 28378429 Paper 28351939 Paper 27803118 Paper 27585671 Paper 27161901 Paper 27057209 Paper 26888364 Paper 26885808 Paper 26868440 Paper 26738099 Paper 26628417 Paper 26606887 Paper 26577415 Paper 26537182 Paper 26531295 Paper 26475177 Paper 26362045 Paper 26340467 Paper 26339570 Paper 26219302 Paper 26181173 Paper 26177958 Paper 26046253 Paper 26036801 Paper 25950206 Paper 25853639 Paper 25784663 Paper 25702853 Paper 25690268 Paper 25677718 Paper 25488617 Paper 25404660 Paper 25392748 Paper 25336561 Paper 25197163 Paper 25109932 Paper 25064711 Paper 24992554 Paper 24987057 Paper 24948348 Paper 24898336 Paper 24840081 Paper 24830985 Paper 24829202 Paper 24819865 Paper 24728128 Paper 24650840 Paper 24450390 Paper 24433565 Paper 24284880 Paper 24204956 Paper 24124113 Paper 24123545 Paper 24123261 Paper 24062330 Paper 24054930 Paper 24030258 Paper 24030069

Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a phase I study using oral Triapine to determine safety and tolerability in patients with advanced solid tumors. The MDT will be determined to recommend the dose for phase II testing by accessing toxicities to this agent. Pharmacokinetics will be done on IV and oral dose Triapine. Peripheral blood mononuclear cells will be evaluated along with gene expression in tumor cells. A secondary end point will be to access tumor response.

View original record on NIH RePORTER →