Biomarkers of Parkinson Disease and Related Disorders

$1,467,613ZIAFY2009NSNIH

National Institute Of Neurological Disorders And Stroke

Investigators

Linked publications & trials

Paper 39173103 Paper 38943336 Paper 38844644 Paper 38718138 Paper 38446362 Paper 38383456 Paper 38366572 Paper 38276245 Paper 38212633 Paper 38066668 Paper 37883190 Paper 37257231 Paper 37147136 Paper 36881269 Paper 36633719 Paper 36507976 Paper 35621196 Paper 35260194 Paper 34842277 Paper 34246578 Paper 34144933 Paper 34076298 Paper 33981791 Paper 33894018 Paper 33710459 Paper 33677553 Paper 33589841 Paper 32700055 Paper 32451338 Paper 32372682 Paper 31335324 Paper 31028127 Paper 30838497 Paper 30798661 Paper 30062642 Paper 29705971 Paper 29475591 Paper 29405350 Paper 29396794 Paper 29294184 Paper 29052077 Paper 29032895 Paper 29030055 Paper 28840582 Paper 28551871 Paper 28315024 Paper 28303413 Paper 28188385 Paper 28093795 Paper 27838780 Paper 27474472 Paper 26920338 Paper 26777075 Paper 26255205 Paper 25829070 Paper 25638582 Paper 25622919 Paper 25589266 Paper 24794098 Paper 24715569 Paper 24706176 Paper 24265239 Paper 24095139 Paper 24095131 Paper 22972639 Paper 22583962 Paper 22451506 Paper 22350211 Paper 22344688 Paper 22297542 Paper 21890520 Paper 21796351 Paper 21762927 Paper 21615193 Paper 21571570 Paper 21279414 Paper 21108771 Paper 20977534 Paper 20623313 Paper 20622073 Paper 19690020 Paper 19399547 Paper 19376983 Paper 19376979 Paper 19266158 Paper 19234788 Paper 19201246 Paper 19155193 Paper 19124673 Paper 19120145 Paper 19120114 Paper 19029530 Paper 18999898 Paper 18801936 Paper 18661549 Paper 18514012 Paper 18498023 Paper 18363034 Paper 18357519 Paper 18325818

Abstract

Among patients with synucleinopathies, severities of putamen dopaminergic denervation, assessed by putamen:occipital cortex ratios of 6-18Ffluorodopa-derived radioactivity, were independent of cardiac noradrenergic denervation, assessed by interventricular septal concentrations of 6-18Ffluorodopamine-derived radioactivity. Scores on the University of Pennsylvania Smell Identification Test (UPSIT) were positively correlated with cardiac 6-18Ffluorodopamine-derived radioactivity, whereas they were unrelated to putamen:occipital cortex ratios of 6-18Ffluorodopa-derived radioactivity, signifying independence of anosmia from putamen dopaminergic denervation in synucleinopathies. In PD, anosmia was associated with physiological evidence of low baroreflex-cardiovagal gain, neurochemical evidence of low baroreflex-sympathoneural gain, and neuroimaging evidence of both cardiac and renal noradrenergic denervation, indicating that in PD anosmia is associated with indices of central and peripheral autonomic failure. Therefore, in alpha-synucleinopathies anosmia, baroreflex failure, and peripheral noradrenergic denervation are related to each other, independently of striatal dopaminergic denervation, and might serve as biomarkers of pre-symptomatic PD. Under a new clinical research protocol (09-N-0010, Biomarkers of Risk of Parkinson Disease) we are addressing whether positive biomarkers of central and peripheral catecholaminergic denervation identify pre-symptomatic PD in people with multiple statistical risk factors.

View original record on NIH RePORTER →