GRID AND SPECIMEN PREPARATION TECHNOLOGIES

$103,178P41FY2009RRNIH

Scripps Research Institute, The, La Jolla CA

Investigators

Linked publications & trials

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Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This projects focuses on the development of novel grid substrate and cryo-EM specimen preparation technologies. The specific aims of the project are: 1.) Explore and evaluate new designs and geometries for holey carbon foils in order to optimize the efficiency of digital image acquisition and the quality of the images acquired with the goal of improving stability, conductivity and specimen flatness. 2.) Systematically investigate factors that influence the production of large areas of thin ice, as well as the way particles orient and are distributed on the holey grids. 3.) Explore and evaluate novel specimen supports designed to address some of the problems associated with carbon support films. The aim is to provide a new substrate with improved mechanical stability, electrical conductivity and flatness.

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