PILOT STUDY OF DCA EFFECTS ON HUMAN TYROSINE METABOLISM

$2,224M01FY2009RRNIH

University Of Florida, Gainesville FL

Investigators

Linked publications, trials & patents

Paper 28914978 Paper 27430519 Paper 26708036 Paper 26683785 Paper 25528738 Paper 25504957 Paper 25365564 Paper 25360766 Paper 25201287 Paper 24779023 Paper 24574081 Paper 24345303 Paper 23957375 Paper 23886594 Paper 23746936 Paper 23611977 Paper 23439301 Paper 23400010 Paper 23129592 Paper 23106421 Paper 23055842 Paper 22859701 Paper 22834845 Paper 22717102 Paper 22584101 Paper 22480771 Paper 22440088 Paper 22383118 Paper 22350108 Paper 21933835 Paper 21923426 Paper 21783234 Paper 21699118 Paper 21570617 Paper 21509714 Paper 21425510 Paper 21337696 Paper 21095320 Paper 21036173 Paper 20958220 Paper 20857838 Paper 20795842 Paper 20736881 Paper 20672296 Paper 20650672 Paper 20573448 Paper 20555294 Paper 20554879 Paper 20551711 Paper 20525997 Paper 20416954 Paper 20410847 Paper 20398118 Paper 20227156 Paper 20150775 Paper 20116944 Paper 20116047 Paper 20112262 Paper 20077430 Paper 20074857 Paper 20047624 Paper 20040621 Paper 19934110 Paper 19917874 Paper 19875605 Paper 19874532 Paper 19792989 Paper 19783002 Paper 19781874 Paper 19706466 Paper 19683849 Paper 19672902 Paper 19671086 Paper 19649137 Paper 19608835 Paper 19595511 Paper 19571804 Paper 19515736 Paper 19475538 Paper 19447923 Paper 19437203 Paper 19420195 Paper 19372693 Paper 19364847 Paper 19344076 Paper 19326398 Paper 19307812 Paper 19299806 Paper 19268553 Paper 19258966 Paper 19244382 Paper 19240050 Paper 19219741 Paper 19193196 Paper 19158217 Paper 19144150 Paper 19101686 Trial NCT00235573 Patent 6391651 Patent 5989551

Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to conduct a proof-of-concept investigation in 3 healthy adults who would receive 13C-U-tyrosine by vein before and after 5 days of 12.5 mg/kg/bid DCA, the typical clinical dose and dose schedule. We will determine tyrosine kinetics by standard kinetic modeling techniques we have employed previously and by GC/MS and LC/MS methods we have developed to identify and quantify both tyrosine and DCA and their metabolites.

View original record on NIH RePORTER →