Estrogen Receptors-Calcium Binding Proteins Interfaces as Targets for the Discove
$1,251P20FY2009MDNIH
Tougaloo College, Tougaloo MS
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Abstract
OBJECTIVE/HYPOTHESIS: Calcium binding proteins (CaBP) like calmodulin mediate unliganded estrogen receptor signaling either by binding directly or through calcium to ER. Our objective is to discover small molecules that mimic/block their association as potential alternatives for tamoxifen resistant breast cancers.
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