Cancer Immunology and Immunotherapy

$22,487P30FY2009CANIH

University Of Iowa, Iowa City IA

Investigators

Linked publications & trials

Paper 39689273 Paper 39678499 Paper 39606473 Paper 39484259 Paper 39471817 Paper 39463996 Paper 39422319 Paper 39393934 Paper 39379789 Paper 39373537 Paper 39369679 Paper 39369582 Paper 39362232 Paper 39349016 Paper 39348280 Paper 39347707 Paper 39345703 Paper 39343511 Paper 39343341 Paper 39337531 Paper 39333185 Paper 39330033 Paper 39329264 Paper 39321424 Paper 39314408 Paper 39302231 Paper 39302103 Paper 39298769 Paper 39297529 Paper 39293732 Paper 39287821 Paper 39287419 Paper 39282910 Paper 39265533 Paper 39259925 Paper 39258889 Paper 39258453 Paper 39257323 Paper 39256770 Paper 39255410 Paper 39248105 Paper 39241503 Paper 39241315 Paper 39233462 Paper 39233229 Paper 39225446 Paper 39222513 Paper 39218742 Paper 39213785 Paper 39213039 Paper 39201571 Paper 39201282 Paper 39195212 Paper 39189932 Paper 39182612 Paper 39179298 Paper 39169840 Paper 39169038 Paper 39168773 Paper 39167632 Paper 39167405 Paper 39154703 Paper 39122837 Paper 39117654 Paper 39116665 Paper 39106773 Paper 39104314 Paper 39104192 Paper 39098912 Paper 39090498 Paper 39083906 Paper 39067718 Paper 39062773 Paper 39061200 Paper 39058497 Paper 39054943 Paper 39054566 Paper 39054536 Paper 39048708 Paper 39044819 Paper 39043185 Paper 39042053 Paper 39025233 Paper 39013125 Paper 39003134 Paper 38996973 Paper 38994839 Paper 38987987 Paper 38976282 Paper 38973234 Paper 38969782 Paper 38943444 Paper 38935626 Paper 38933441 Paper 38932746 Paper 38926643 Paper 38925101 Paper 38914309 Paper 38911126 Paper 38904226

Abstract

Research in the Cancer Immunology and Immunotherapy Program focuses on how immune cell and immune system functions impact on cancer biology. The overall goals of the members of this program extend from enhancing our basic understanding of the mechanisms by which receptors and molecules impact on immune system function through applying these basic observations to the design and evaluation of new therapies for various types of malignancy. There are two major overlapping themes within the Program's research. Theme 1 - Understanding the cellular and molecular mechanisms of immune cell function. Theme 2 - The design and testing of novel immunotherapies. New basic research findings resulting in numerous publications and several new cancer-focused research grants have developed within the Cancer Immunology and Immunotherapy Program. The program has been particularly successful at effectively translating basic science advances to the clinic. For example, members of the program have been instrumental in (a) exploring basic mechanisms of B-cell signaling and how they impact on malignant transformation, (b) describing the immunologic effects of the TLR9 agonist CpG ODN, and applying this knowledge to novel clinical approaches to cancer immunotherapy, and (c) developing novel approaches to cancer vaccines. There are numerous past and present productive collaborations both between members of the Program, and with members of other Cancer Center programs. An example of this success is the NCI-funded Lymphoma SPORE. The Cancer Immunology and Immunotherapy program consists of 32 members from 8 departments in 2 colleges. Peer-re vie wed, direct research funding for this program totals $6,890,376, with $2,474,927 of this support coming from the NCI.

View original record on NIH RePORTER →