Putting Electrospun Nanofibers to Work for Musculoskeletal Research

$75,607P30FY2009ARNIH

Washington University, Saint Louis MO

Investigators

Linked publications & trials

Paper 38659818 Paper 37534578 Paper 37203780 Paper 37002920 Paper 36583692 Paper 36116429 Paper 36091331 Paper 35318397 Paper 35142107 Paper 34551967 Paper 34542191 Paper 34520398 Paper 34426569 Paper 34405443 Paper 34276675 Paper 34251273 Paper 34203046 Paper 34144232 Paper 34118078 Paper 34031510 Paper 33831261 Paper 33785647 Paper 33671535 Paper 33662611 Paper 33526766 Paper 33348259 Paper 33246158 Paper 33245915 Paper 33199631 Paper 33181349 Paper 33016623 Paper 32979208 Paper 32744762 Paper 32736506 Paper 32647171 Paper 32635993 Paper 32576566 Paper 32518174 Paper 32434850 Paper 32276247 Paper 32227614 Paper 32165499 Paper 32127497 Paper 32047703 Paper 31995253 Paper 31926267 Paper 31909538 Paper 31875721 Paper 31874220 Paper 31801815 Paper 31768488 Paper 31681908 Paper 31646754 Paper 31611846 Paper 31578308 Paper 31534049 Paper 31465513 Paper 31413938 Paper 31369916 Paper 31320680 Paper 31296738 Paper 31290205 Paper 31286564 Paper 31246323 Paper 31235574 Paper 31233501 Paper 31206783 Paper 31167128 Paper 31138692 Paper 31115161 Paper 31107556 Paper 31081125 Paper 31042310 Paper 31031229 Paper 30998643 Paper 30983912 Paper 30977548 Paper 30968743 Paper 30913395 Paper 30898695 Paper 30828688 Paper 30803986 Paper 30680359 Paper 30679644 Paper 30674675 Paper 30665565 Paper 30663342 Paper 30656719 Paper 30648276 Paper 30644575 Paper 30617265 Paper 30615803 Paper 30394938 Paper 30266822 Paper 30259572 Paper 30259220 Paper 30225954 Paper 30173558 Paper 30159908 Paper 30099615

Abstract

This project is a collaborative effort involving investigators from the Departments of Biomedical Engineering and Orthopaedic Surgery at Washington University in St. Louis. The main goal of this project is to develop and validate electrospun nanofibers as a new platform for musculoskeletal research, with an initial focus on the demonstration of scaffolds for tissue repairing at the tendon-to-bone insertion site. In this project, we will fabricate nanofibers by electrospinning and then optimize their use as scaffolds for tissue engineering by in vitro cell culture studies. We will then evaluate the performance of these nanofibrous scaffolds in vivo using a clinical-relevant animal model for the repair of supraspinatus tendon at the insertion site.

View original record on NIH RePORTER →