FUNCTIONAL SUBSTRUCTURE OF FLAGELLAR DYNEIN
$285,097R01FY2000GMNIH
Emory University, Atlanta GA
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Abstract
DESCRIPTION: Dr. Sale proposes to define the mechanisms that regulate dynein activity by modulating motor function and controlling where the motor is localized. Two specific aims are proposed: (1) to determine how changes in IC138 phosphorylation regulate the I1 dynein complex; and (2) to determine the mechanism by which I1 is targeted to the inner doublet microtubules, and to test the hypothesis that axonemal kinase and phosphatase are anchored.
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