Endogenous Nitrite Carcinogenesis in Man

$1,770,538P01FY2009CANIH

Massachusetts Institute Of Technology, Cambridge MA

Investigators

Linked publications & trials

Paper 38241440 Paper 33314311 Paper 33145399 Paper 32519858 Paper 32484547 Paper 32452708 Paper 32447242 Paper 32303148 Paper 31387777 Paper 30977112 Paper 30587213 Paper 30466063 Paper 30309820 Paper 30195448 Paper 30108260 Paper 30009260 Paper 29988084 Paper 29929044 Paper 29289706 Paper 29271637 Paper 28755435 Paper 28692800 Paper 28394575 Paper 28370323 Paper 28269980 Paper 28265096 Paper 28198364 Paper 27305824 Paper 27035958 Paper 26919079 Paper 26866676 Paper 26344235 Paper 26283391 Paper 26243878 Paper 26152727 Paper 26080406 Paper 25837992 Paper 25772370 Paper 25733867 Paper 25647331 Paper 25516996 Paper 25482136 Paper 25448597 Paper 25381744 Paper 25184625 Paper 25157679 Paper 25155011 Paper 25071207 Paper 24901438 Paper 24853076 Paper 24733044 Paper 24696515 Paper 24618785 Paper 24513446 Paper 24505273 Paper 24301796 Paper 24252063 Paper 24185942 Paper 24087891 Paper 24051318 Paper 23962822 Paper 23951007 Paper 23929035 Paper 23926919 Paper 23878245 Paper 23820270 Paper 23773213 Paper 23754421 Paper 23707620 Paper 23631432 Paper 23630959 Paper 23614769 Paper 23506120 Paper 23468656 Paper 23185001 Paper 23140136 Paper 23085517 Paper 23057664 Paper 23043808 Paper 23041631 Paper 23027534 Paper 23015502 Paper 23015501 Paper 22998585 Paper 22971010 Paper 22957933 Paper 22728703 Paper 22689960 Paper 22538203 Paper 22512456 Paper 22308425 Paper 22303861 Paper 22263561 Paper 22184416 Paper 22103813 Paper 22041025 Paper 21849622 Paper 21768395 Paper 21546560 Paper 21426337

Abstract

DESCRIPTION (provided by applicant): The long term objective of this Program is to develop a mechanistic understanding of the causal relationship of inflammation to cancer. A specific objective is to determine the role of Nitric Oxide (NO) in the process of inflammation-induced carcinogenesis and in the maintenance of the melanoma cancer cell. The results of these investigations will be applied in a translational manner to human cancers and pre-cancerous states, including inflammatory bowel disease (IBD), colon cancer, and melanoma. The research will utilize cells in culture and animal models. The animal models will be used to develop biomarkers of inflammation chemistry that can be applied to archived human tissue to determine whether the animal model represents the human case. The biomarkers can then be used to develop a therapeutic approach to cancer prevention. This Program has already demonstrated that NO-synthase inhibitors can ameliorate the early stages of tissue changes in IBD and colon cancer in our animal models.

View original record on NIH RePORTER →